Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02138:Or1p1c'

281411

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or1p1c

Ensembl Gene

ENSMUSG00000070375

Gene Name

olfactory receptor family 1 subfamily P member 1C

Synonyms

Olfr406, MOR133-1, Olfr406-ps, GA_x6K02T2P1NL-4415162-4416133

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.055) question?

Stock #

IGL02138

Quality Score

Status

Chromosome

Chromosomal Location

74160217-74161188 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 74160544 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Leucine at position 110 (M110L)

Ref Sequence

ENSEMBL: ENSMUSP00000148929 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000133561] [ENSMUST00000214303] [ENSMUST00000217016]

AlphaFold

Q7TRX0

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000127098

Predicted Effect

probably benign
Transcript: ENSMUST00000133561
AA Change: M110L

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)

SMART Domains

Protein: ENSMUSP00000125963
Gene: ENSMUSG00000070375
AA Change: M110L

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	310	3.5e-56	PFAM
Pfam:7tm_1	41	292	3e-27	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000214303
AA Change: M110L

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)

Predicted Effect

probably benign
Transcript: ENSMUST00000217016
AA Change: M110L

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
3425401B19Rik	T	G	14: 32,384,672 (GRCm39)	D431A	possibly damaging	Het
Adgrb1	T	C	15: 74,401,631 (GRCm39)	M209T	probably damaging	Het
Ano8	T	C	8: 71,937,486 (GRCm39)	H86R	probably damaging	Het
Camk1d	G	T	2: 5,449,895 (GRCm39)	Y87*	probably null	Het
Capza3	A	G	6: 139,987,872 (GRCm39)	D157G	probably benign	Het
Ckmt2	A	T	13: 92,009,947 (GRCm39)	D124E	probably benign	Het
Col14a1	C	A	15: 55,284,231 (GRCm39)	Q831K	unknown	Het
Copb2	C	T	9: 98,469,605 (GRCm39)	P829S	probably benign	Het
Dlg5	A	G	14: 24,208,419 (GRCm39)	V929A	probably benign	Het
Dolk	A	G	2: 30,175,991 (GRCm39)	V18A	probably benign	Het
Ecm2	G	T	13: 49,676,304 (GRCm39)	L340F	probably damaging	Het
Hacl1	A	G	14: 31,352,940 (GRCm39)	L149P	probably benign	Het
Higd2a	A	T	13: 54,738,235 (GRCm39)		probably null	Het
Hspa12a	A	T	19: 58,816,730 (GRCm39)	S28R	probably benign	Het
Igkv5-37	A	G	6: 69,940,435 (GRCm39)	Y70H	probably damaging	Het
Iho1	G	A	9: 108,283,820 (GRCm39)	T208I	probably benign	Het
Kif11	T	C	19: 37,373,057 (GRCm39)	V92A	probably damaging	Het
Kif26a	T	C	12: 112,141,284 (GRCm39)	S696P	probably damaging	Het
Kng1	A	T	16: 22,886,558 (GRCm39)	N168Y	probably damaging	Het
Krt26	C	T	11: 99,224,471 (GRCm39)	R349Q	probably benign	Het
Lepr	A	G	4: 101,625,264 (GRCm39)	D473G	probably damaging	Het
Lipt1	G	A	1: 37,914,867 (GRCm39)	E308K	possibly damaging	Het
Luc7l3	A	T	11: 94,194,792 (GRCm39)	F76Y	probably benign	Het
Mapk1	A	G	16: 16,841,316 (GRCm39)	I163V	probably benign	Het
Matn3	A	G	12: 9,017,638 (GRCm39)	E430G	possibly damaging	Het
Med13	A	T	11: 86,177,591 (GRCm39)	S1502T	probably damaging	Het
Mlf1	A	T	3: 67,307,046 (GRCm39)	H237L	probably benign	Het
Mss51	A	C	14: 20,534,923 (GRCm39)	Y282*	probably null	Het
Ncoa3	A	G	2: 165,897,182 (GRCm39)	T658A	probably benign	Het
Or7d11	A	T	9: 19,966,196 (GRCm39)	S188T	probably benign	Het
Phrf1	T	A	7: 140,839,196 (GRCm39)		probably benign	Het
Ppme1	C	T	7: 99,983,139 (GRCm39)	M335I	probably damaging	Het
Ror2	C	T	13: 53,264,764 (GRCm39)	S764N	probably damaging	Het
Sntg2	T	A	12: 30,357,230 (GRCm39)		probably null	Het
Spryd3	T	C	15: 102,027,354 (GRCm39)		probably benign	Het
Srpx	A	G	X: 9,933,662 (GRCm39)		probably null	Het
St8sia1	G	T	6: 142,909,504 (GRCm39)		probably benign	Het
Stab1	A	G	14: 30,865,470 (GRCm39)		probably null	Het
Sycp2	A	T	2: 178,000,047 (GRCm39)	S976R	probably benign	Het
Sycp2	T	A	2: 178,043,783 (GRCm39)	K108*	probably null	Het
Tagap1	T	C	17: 7,223,485 (GRCm39)	T404A	probably damaging	Het
Tg	C	T	15: 66,589,082 (GRCm39)	T21I	probably benign	Het
Tlr4	A	T	4: 66,759,202 (GRCm39)	Y665F	probably damaging	Het
Tmc8	T	G	11: 117,682,081 (GRCm39)	S525A	probably benign	Het
Tor4a	A	T	2: 25,084,810 (GRCm39)	D364E	probably benign	Het
Trim44	T	C	2: 102,211,253 (GRCm39)	I236V	probably benign	Het
Ube2o	A	G	11: 116,434,226 (GRCm39)		probably benign	Het
Wdr38	A	T	2: 38,888,424 (GRCm39)	N7I	probably damaging	Het
Xirp2	A	T	2: 67,347,300 (GRCm39)	R3180S	probably benign	Het
Zfp335	A	G	2: 164,735,724 (GRCm39)	C1077R	probably damaging	Het

Other mutations in Or1p1c

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01370:Or1p1c	APN	11	74,160,325 (GRCm39)	missense	probably benign	0.01
IGL01480:Or1p1c	APN	11	74,160,427 (GRCm39)	missense	possibly damaging	0.64
IGL02986:Or1p1c	APN	11	74,160,928 (GRCm39)	missense	possibly damaging	0.82
R0018:Or1p1c	UTSW	11	74,160,934 (GRCm39)	missense	probably benign	0.39
R1822:Or1p1c	UTSW	11	74,161,066 (GRCm39)	missense	probably benign	0.11
R1823:Or1p1c	UTSW	11	74,161,043 (GRCm39)	missense	probably damaging	1.00
R1956:Or1p1c	UTSW	11	74,160,670 (GRCm39)	missense	probably damaging	1.00
R2017:Or1p1c	UTSW	11	74,161,159 (GRCm39)	missense	probably benign
R2879:Or1p1c	UTSW	11	74,161,049 (GRCm39)	missense	probably damaging	1.00
R3854:Or1p1c	UTSW	11	74,161,105 (GRCm39)	nonsense	probably null
R4750:Or1p1c	UTSW	11	74,160,246 (GRCm39)	missense	probably benign	0.00
R6076:Or1p1c	UTSW	11	74,161,088 (GRCm39)	missense	probably damaging	1.00
R6257:Or1p1c	UTSW	11	74,160,833 (GRCm39)	missense	probably damaging	1.00
R6431:Or1p1c	UTSW	11	74,160,235 (GRCm39)	missense	possibly damaging	0.95
R7032:Or1p1c	UTSW	11	74,160,428 (GRCm39)	missense	possibly damaging	0.95
R7216:Or1p1c	UTSW	11	74,160,550 (GRCm39)	missense	probably damaging	1.00
R7429:Or1p1c	UTSW	11	74,160,579 (GRCm39)	missense	probably damaging	1.00
R8144:Or1p1c	UTSW	11	74,160,384 (GRCm39)	missense	probably damaging	0.98
R8161:Or1p1c	UTSW	11	74,160,544 (GRCm39)	missense	probably benign	0.01
R8847:Or1p1c	UTSW	11	74,160,443 (GRCm39)	missense	probably damaging	1.00
R8872:Or1p1c	UTSW	11	74,160,120 (GRCm39)	splice site	probably benign
R8977:Or1p1c	UTSW	11	74,160,304 (GRCm39)	missense	probably benign	0.02
R9049:Or1p1c	UTSW	11	74,161,115 (GRCm39)	missense	possibly damaging	0.80
R9336:Or1p1c	UTSW	11	74,160,743 (GRCm39)	missense	probably damaging	0.98
R9596:Or1p1c	UTSW	11	74,160,289 (GRCm39)	missense	probably benign
R9771:Or1p1c	UTSW	11	74,160,635 (GRCm39)	missense	probably benign	0.05

Posted On

2015-04-16