Incidental Mutation 'IGL02143:Or2ag13'
ID 281666
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or2ag13
Ensembl Gene ENSMUSG00000108948
Gene Name olfactory receptor family 2 subfamily AG member 13
Synonyms Olfr695, GA_x6K02T2PBJ9-9092181-9091234, MOR283-6
Accession Numbers
Essential gene? Probably non essential (E-score: 0.121) question?
Stock # IGL02143
Quality Score
Status
Chromosome 7
Chromosomal Location 106312939-106315552 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 106473180 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 91 (T91A)
Ref Sequence ENSEMBL: ENSMUSP00000150853 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060879] [ENSMUST00000213721] [ENSMUST00000216009]
AlphaFold Q8VFM3
Predicted Effect probably benign
Transcript: ENSMUST00000060879
AA Change: T91A

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000050694
Gene: ENSMUSG00000109058
AA Change: T91A

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 5.2e-46 PFAM
Pfam:7TM_GPCR_Srsx 35 296 1.8e-6 PFAM
Pfam:7tm_1 41 290 2.1e-26 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213721
AA Change: T91A

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
Predicted Effect probably benign
Transcript: ENSMUST00000216009
AA Change: T91A

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217164
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217204
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd5 T C 9: 122,194,278 (GRCm39) M1T probably null Het
Ager G A 17: 34,818,092 (GRCm39) G183E probably damaging Het
Alcam C A 16: 52,125,982 (GRCm39) V112L probably damaging Het
Amot T A X: 144,270,024 (GRCm39) Q204H probably damaging Het
Ankar C T 1: 72,697,808 (GRCm39) probably null Het
Armc9 A G 1: 86,104,587 (GRCm39) M279V possibly damaging Het
Bpifb1 C T 2: 154,051,849 (GRCm39) T218I probably benign Het
Cacna1f A C X: 7,480,234 (GRCm39) probably benign Het
Cacna2d2 T C 9: 107,395,474 (GRCm39) probably null Het
Ccdc57 A T 11: 120,752,069 (GRCm39) C837* probably null Het
Ctbp2 G A 7: 132,592,885 (GRCm39) A808V probably damaging Het
Dcbld2 T C 16: 58,268,889 (GRCm39) probably null Het
Dis3 T C 14: 99,328,754 (GRCm39) probably benign Het
Disp2 T C 2: 118,620,450 (GRCm39) F394S probably damaging Het
Dnah1 T C 14: 31,005,246 (GRCm39) N2336S probably damaging Het
Drap1 C A 19: 5,473,871 (GRCm39) L66F probably damaging Het
Eif5a2 C T 3: 28,847,888 (GRCm39) R109C probably benign Het
Enpp1 A T 10: 24,553,872 (GRCm39) D105E probably damaging Het
Evi5l G A 8: 4,241,293 (GRCm39) M275I probably damaging Het
Flt1 T C 5: 147,515,246 (GRCm39) T1059A probably benign Het
Fndc3c1 T C X: 105,516,340 (GRCm39) probably benign Het
Git1 T C 11: 77,396,813 (GRCm39) V645A possibly damaging Het
Gm7735 T A 16: 88,966,437 (GRCm39) C20* probably null Het
Ighv1-42 G T 12: 114,900,906 (GRCm39) P60T probably benign Het
Jakmip2 A T 18: 43,696,350 (GRCm39) L533Q probably damaging Het
Kdm2b C T 5: 123,085,898 (GRCm39) E238K probably damaging Het
Lpin2 T C 17: 71,550,921 (GRCm39) S694P probably damaging Het
Mab21l2 C T 3: 86,454,562 (GRCm39) R146Q possibly damaging Het
Mmp1b A T 9: 7,386,400 (GRCm39) S174T probably benign Het
Neb T C 2: 52,181,211 (GRCm39) Y1132C probably damaging Het
Nhsl1 A T 10: 18,387,383 (GRCm39) H219L possibly damaging Het
Nwd2 T A 5: 63,948,996 (GRCm39) probably null Het
Obp1a A C X: 77,134,449 (GRCm39) M18R possibly damaging Het
Or13a19 A T 7: 139,903,505 (GRCm39) K298* probably null Het
Pabpc5 T A X: 118,837,688 (GRCm39) M1K probably null Het
Paxip1 A G 5: 27,980,596 (GRCm39) probably benign Het
Perm1 A G 4: 156,302,500 (GRCm39) E348G probably benign Het
Pfkfb1 T C X: 149,405,138 (GRCm39) F170L probably damaging Het
Pou3f3 A G 1: 42,737,686 (GRCm39) M461V probably benign Het
Ppfia2 G A 10: 106,693,360 (GRCm39) D622N probably damaging Het
Prtg T G 9: 72,799,606 (GRCm39) S801R probably damaging Het
Rars2 T A 4: 34,623,404 (GRCm39) probably benign Het
Rasal1 A G 5: 120,790,917 (GRCm39) D35G probably damaging Het
Repin1 T A 6: 48,574,055 (GRCm39) L272Q probably damaging Het
Spmip5 C A 19: 58,777,684 (GRCm39) R34L possibly damaging Het
Stk36 T C 1: 74,655,728 (GRCm39) probably benign Het
Tbxa2r A G 10: 81,170,320 (GRCm39) T269A probably benign Het
Tmem132c G A 5: 127,640,466 (GRCm39) R879Q probably benign Het
Vmn1r78 C A 7: 11,886,407 (GRCm39) A6E probably benign Het
Vps45 A T 3: 95,941,133 (GRCm39) N369K probably benign Het
Vps45 T C 3: 95,926,958 (GRCm39) I530V probably benign Het
Zkscan16 G A 4: 58,956,911 (GRCm39) G398R probably damaging Het
Other mutations in Or2ag13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01010:Or2ag13 APN 7 106,473,460 (GRCm39) utr 5 prime probably benign
R0492:Or2ag13 UTSW 7 106,473,084 (GRCm39) missense probably damaging 1.00
R1816:Or2ag13 UTSW 7 106,472,695 (GRCm39) nonsense probably null
R1834:Or2ag13 UTSW 7 106,473,348 (GRCm39) missense probably damaging 1.00
R2011:Or2ag13 UTSW 7 106,472,634 (GRCm39) missense probably benign 0.03
R3434:Or2ag13 UTSW 7 106,472,976 (GRCm39) missense probably benign 0.01
R3842:Or2ag13 UTSW 7 106,473,302 (GRCm39) missense probably benign 0.07
R4405:Or2ag13 UTSW 7 106,472,580 (GRCm39) missense probably damaging 1.00
R4742:Or2ag13 UTSW 7 106,472,635 (GRCm39) missense probably damaging 0.99
R4815:Or2ag13 UTSW 7 106,473,444 (GRCm39) missense probably benign
R4851:Or2ag13 UTSW 7 106,473,221 (GRCm39) missense probably damaging 1.00
R4856:Or2ag13 UTSW 7 106,473,177 (GRCm39) missense probably damaging 1.00
R5663:Or2ag13 UTSW 7 106,472,877 (GRCm39) missense probably benign 0.43
R5783:Or2ag13 UTSW 7 106,472,541 (GRCm39) missense probably damaging 0.97
R6552:Or2ag13 UTSW 7 106,313,850 (GRCm39) small deletion probably benign
R6640:Or2ag13 UTSW 7 106,313,247 (GRCm39) missense probably damaging 1.00
R6798:Or2ag13 UTSW 7 106,313,402 (GRCm39) missense probably damaging 1.00
R7365:Or2ag13 UTSW 7 106,313,171 (GRCm39) missense probably benign 0.03
R7496:Or2ag13 UTSW 7 106,313,435 (GRCm39) missense probably benign 0.23
R7923:Or2ag13 UTSW 7 106,313,649 (GRCm39) nonsense probably null
R9012:Or2ag13 UTSW 7 106,313,115 (GRCm39) missense probably benign 0.10
R9572:Or2ag13 UTSW 7 106,313,546 (GRCm39) missense probably damaging 1.00
R9596:Or2ag13 UTSW 7 106,313,412 (GRCm39) missense probably benign 0.01
R9756:Or2ag13 UTSW 7 106,313,002 (GRCm39) missense probably benign
Posted On 2015-04-16