Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02154:Armc3'

282177

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Armc3

Ensembl Gene

ENSMUSG00000037683

Gene Name

armadillo repeat containing 3

Synonyms

4921513G22Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.064) question?

Stock #

IGL02154

Quality Score

Status

Chromosome

Chromosomal Location

19204113-19315052 bp(+) (GRCm39)

Type of Mutation

critical splice donor site (1 bp from exon)

DNA Base Change (assembly)

G to A at 19290948 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000110287 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000049255] [ENSMUST00000114640]

AlphaFold

A2AU72

Predicted Effect

probably null
Transcript: ENSMUST00000049255

SMART Domains

Protein: ENSMUSP00000048784
Gene: ENSMUSG00000037683

Domain	Start	End	E-Value	Type
low complexity region	3	14	N/A	INTRINSIC
ARM	56	96	2.07e-2	SMART
ARM	97	138	9.84e1	SMART
ARM	139	179	7.86e-3	SMART
ARM	180	220	7.63e0	SMART
ARM	221	262	7.76e1	SMART
low complexity region	293	303	N/A	INTRINSIC
ARM	305	345	3.91e1	SMART
ARM	346	385	2.93e-2	SMART
ARM	387	427	7.74e-2	SMART
Blast:ARM	428	468	3e-11	BLAST
ARM	469	509	1.45e-1	SMART
low complexity region	544	557	N/A	INTRINSIC
low complexity region	583	595	N/A	INTRINSIC
low complexity region	620	639	N/A	INTRINSIC
low complexity region	675	696	N/A	INTRINSIC
Pfam:EDR1	723	857	3.1e-28	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000114640

SMART Domains

Protein: ENSMUSP00000110287
Gene: ENSMUSG00000037683

Domain	Start	End	E-Value	Type
low complexity region	3	14	N/A	INTRINSIC
ARM	56	96	2.07e-2	SMART
ARM	97	138	9.84e1	SMART
ARM	139	179	7.86e-3	SMART
ARM	180	220	7.63e0	SMART
ARM	221	262	7.76e1	SMART
low complexity region	293	303	N/A	INTRINSIC
ARM	305	345	3.91e1	SMART
ARM	346	385	2.93e-2	SMART
ARM	387	427	7.74e-2	SMART
Blast:ARM	428	468	3e-11	BLAST
ARM	469	509	1.45e-1	SMART
Pfam:EDR1	549	868	1.4e-41	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Armadillo/beta-catenin (CTNNB1; MIM 116806)-like (ARM) domains are imperfect 45-amino acid repeats involved in protein-protein interactions. ARM domain-containing proteins, such as ARMC3, function in signal transduction, development, cell adhesion and mobility, and tumor initiation and metastasis (Li et al., 2006 [PubMed 16915934]).[supplied by OMIM, Mar 2008]

Allele List at MGI

All alleles(2) : Targeted(2)

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Armh4	G	A	14: 50,010,399 (GRCm39)	T436I	possibly damaging	Het
AW551984	G	A	9: 39,500,398 (GRCm39)	R787C	possibly damaging	Het
Cadm1	A	T	9: 47,725,201 (GRCm39)	I321L	probably benign	Het
Cfap57	A	G	4: 118,470,214 (GRCm39)	L222P	probably damaging	Het
Cox20	A	G	1: 178,150,119 (GRCm39)	I98V	probably benign	Het
Dmrta1	A	G	4: 89,580,150 (GRCm39)	N370S	probably benign	Het
Dnah17	A	G	11: 118,015,087 (GRCm39)	F386L	probably benign	Het
Fam135b	T	C	15: 71,320,559 (GRCm39)	I1323V	probably benign	Het
Fndc3b	A	G	3: 27,592,266 (GRCm39)	S211P	probably damaging	Het
Galnt10	T	G	11: 57,675,531 (GRCm39)	L597V	probably damaging	Het
Gtf2e2	T	C	8: 34,245,989 (GRCm39)		probably null	Het
Inpp4b	T	A	8: 82,696,130 (GRCm39)		probably benign	Het
Irag2	T	G	6: 145,083,967 (GRCm39)	M44R	possibly damaging	Het
Lacc1	A	G	14: 77,270,727 (GRCm39)	V269A	probably benign	Het
Mdn1	A	G	4: 32,740,395 (GRCm39)	D3750G	probably benign	Het
Mme	A	T	3: 63,250,976 (GRCm39)	Q339L	probably benign	Het
Mmp3	A	T	9: 7,453,662 (GRCm39)	I428L	probably benign	Het
Myrf	A	T	19: 10,193,482 (GRCm39)	I558N	probably damaging	Het
Or52e8	C	T	7: 104,625,188 (GRCm39)	M1I	probably null	Het
Phb1	A	G	11: 95,565,997 (GRCm39)	I94V	possibly damaging	Het
Prg4	T	A	1: 150,330,613 (GRCm39)		probably benign	Het
Sirpb1a	T	C	3: 15,475,504 (GRCm39)	T344A	probably damaging	Het
Skap2	T	C	6: 51,989,308 (GRCm39)		probably benign	Het
Slc29a1	A	G	17: 45,897,089 (GRCm39)	I399T	probably damaging	Het
Sorl1	C	T	9: 41,915,330 (GRCm39)	V1300I	probably benign	Het
Tas2r117	T	C	6: 132,780,678 (GRCm39)	V272A	probably benign	Het
Tctn2	C	A	5: 124,746,624 (GRCm39)		noncoding transcript	Het
Tmem51	T	C	4: 141,759,089 (GRCm39)	N220D	probably damaging	Het
Trak2	T	C	1: 58,947,888 (GRCm39)	D584G	probably damaging	Het
Vmn1r78	A	G	7: 11,886,472 (GRCm39)	I28V	probably benign	Het
Vmn2r95	A	C	17: 18,672,248 (GRCm39)	I662L	probably benign	Het
Vwa8	C	A	14: 79,086,733 (GRCm39)	R4S	possibly damaging	Het

Other mutations in Armc3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00535:Armc3	APN	2	19,308,669 (GRCm39)	missense	possibly damaging	0.48
IGL01123:Armc3	APN	2	19,206,616 (GRCm39)	missense	possibly damaging	0.87
IGL01142:Armc3	APN	2	19,302,709 (GRCm39)	splice site	probably benign
IGL01556:Armc3	APN	2	19,273,957 (GRCm39)	missense	probably damaging	1.00
IGL02145:Armc3	APN	2	19,290,948 (GRCm39)	critical splice donor site	probably null
IGL02145:Armc3	APN	2	19,301,671 (GRCm39)	missense	possibly damaging	0.81
IGL02152:Armc3	APN	2	19,290,948 (GRCm39)	critical splice donor site	probably null
IGL02243:Armc3	APN	2	19,290,948 (GRCm39)	critical splice donor site	probably null
IGL02244:Armc3	APN	2	19,290,948 (GRCm39)	critical splice donor site	probably null
IGL02516:Armc3	APN	2	19,305,317 (GRCm39)	missense	possibly damaging	0.94
IGL02691:Armc3	APN	2	19,240,295 (GRCm39)	missense	probably damaging	1.00
IGL03151:Armc3	APN	2	19,243,509 (GRCm39)	missense	probably damaging	1.00
IGL03190:Armc3	APN	2	19,293,761 (GRCm39)	missense	probably damaging	0.99
IGL03288:Armc3	APN	2	19,240,293 (GRCm39)	missense	probably damaging	1.00
IGL03338:Armc3	APN	2	19,253,512 (GRCm39)	missense	possibly damaging	0.88
R0015:Armc3	UTSW	2	19,301,132 (GRCm39)	critical splice acceptor site	probably null
R0015:Armc3	UTSW	2	19,301,132 (GRCm39)	critical splice acceptor site	probably null
R0256:Armc3	UTSW	2	19,274,027 (GRCm39)	missense	probably damaging	1.00
R0621:Armc3	UTSW	2	19,300,204 (GRCm39)	missense	probably damaging	0.96
R1326:Armc3	UTSW	2	19,314,935 (GRCm39)	makesense	probably null
R1470:Armc3	UTSW	2	19,243,547 (GRCm39)	missense	probably benign
R1470:Armc3	UTSW	2	19,243,547 (GRCm39)	missense	probably benign
R1489:Armc3	UTSW	2	19,314,858 (GRCm39)	missense	probably benign	0.01
R1990:Armc3	UTSW	2	19,297,953 (GRCm39)	missense	probably damaging	0.97
R1991:Armc3	UTSW	2	19,297,953 (GRCm39)	missense	probably damaging	0.97
R1992:Armc3	UTSW	2	19,297,953 (GRCm39)	missense	probably damaging	0.97
R2002:Armc3	UTSW	2	19,293,747 (GRCm39)	missense	probably benign	0.01
R2095:Armc3	UTSW	2	19,293,740 (GRCm39)	missense	possibly damaging	0.65
R2127:Armc3	UTSW	2	19,206,622 (GRCm39)	missense	probably damaging	1.00
R2158:Armc3	UTSW	2	19,253,444 (GRCm39)	missense	probably damaging	0.99
R2697:Armc3	UTSW	2	19,308,746 (GRCm39)	missense	probably damaging	1.00
R3809:Armc3	UTSW	2	19,305,476 (GRCm39)	missense	probably damaging	1.00
R3897:Armc3	UTSW	2	19,273,988 (GRCm39)	missense	probably damaging	1.00
R4107:Armc3	UTSW	2	19,293,720 (GRCm39)	missense	probably benign	0.13
R4326:Armc3	UTSW	2	19,305,284 (GRCm39)	missense	probably damaging	0.97
R4464:Armc3	UTSW	2	19,253,470 (GRCm39)	missense	probably damaging	0.99
R4702:Armc3	UTSW	2	19,314,792 (GRCm39)	missense	probably damaging	1.00
R4923:Armc3	UTSW	2	19,297,791 (GRCm39)	critical splice acceptor site	probably null
R5370:Armc3	UTSW	2	19,290,873 (GRCm39)	missense	probably benign	0.00
R5518:Armc3	UTSW	2	19,302,739 (GRCm39)	missense	probably benign	0.28
R5718:Armc3	UTSW	2	19,308,610 (GRCm39)	nonsense	probably null
R5739:Armc3	UTSW	2	19,258,728 (GRCm39)	missense	possibly damaging	0.67
R5913:Armc3	UTSW	2	19,314,858 (GRCm39)	missense	possibly damaging	0.65
R6211:Armc3	UTSW	2	19,301,614 (GRCm39)	critical splice acceptor site	probably null
R6245:Armc3	UTSW	2	19,253,516 (GRCm39)	missense	probably damaging	1.00
R6841:Armc3	UTSW	2	19,206,630 (GRCm39)	splice site	probably null
R7003:Armc3	UTSW	2	19,274,839 (GRCm39)	missense	probably damaging	1.00
R7190:Armc3	UTSW	2	19,297,947 (GRCm39)	missense	probably damaging	1.00
R7499:Armc3	UTSW	2	19,290,790 (GRCm39)	missense	probably benign	0.03
R7738:Armc3	UTSW	2	19,293,761 (GRCm39)	missense	probably damaging	0.99
R7844:Armc3	UTSW	2	19,258,829 (GRCm39)	missense	possibly damaging	0.90
R7919:Armc3	UTSW	2	19,290,906 (GRCm39)	missense	probably benign	0.00
R8060:Armc3	UTSW	2	19,293,720 (GRCm39)	missense	probably benign	0.08
R8111:Armc3	UTSW	2	19,301,674 (GRCm39)	missense	probably benign
R8406:Armc3	UTSW	2	19,240,365 (GRCm39)	missense	probably damaging	0.98
R8485:Armc3	UTSW	2	19,297,945 (GRCm39)	missense	probably damaging	1.00
R8773:Armc3	UTSW	2	19,293,667 (GRCm39)	missense	probably benign	0.01
R8940:Armc3	UTSW	2	19,240,393 (GRCm39)	missense	probably damaging	1.00
R9441:Armc3	UTSW	2	19,253,426 (GRCm39)	missense	possibly damaging	0.89
Z1177:Armc3	UTSW	2	19,290,802 (GRCm39)	missense	probably benign

Posted On

2015-04-16