Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00959:Gm11437'

28599

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gm11437

Ensembl Gene

ENSMUSG00000051452

Gene Name

predicted gene 11437

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.089) question?

Stock #

IGL00959

Quality Score

Status

Chromosome

Chromosomal Location

84039187-84058302 bp(-) (GRCm39)

Type of Mutation

intron

DNA Base Change (assembly)

A to C at 84039448 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000116174 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000050771] [ENSMUST00000133811]

AlphaFold

Q5QR91

Predicted Effect

probably benign
Transcript: ENSMUST00000050771

SMART Domains

Protein: ENSMUSP00000056084
Gene: ENSMUSG00000051452

Domain	Start	End	E-Value	Type
Pfam:DUF4711	1	226	7.4e-102	PFAM
low complexity region	227	238	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000133811

SMART Domains

Protein: ENSMUSP00000116174
Gene: ENSMUSG00000020532

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
PDB:2YL2\|B	115	157	2e-21	PDB

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Alox12b	A	T	11: 69,057,069 (GRCm39)	H430L	probably damaging	Het
Aox4	G	T	1: 58,278,333 (GRCm39)	V443F	probably damaging	Het
Bmpr2	A	T	1: 59,854,474 (GRCm39)	I108F	possibly damaging	Het
Cflar	G	A	1: 58,768,321 (GRCm39)		probably null	Het
Chchd3	A	G	6: 32,945,188 (GRCm39)	V106A	probably benign	Het
Chl1	G	T	6: 103,686,211 (GRCm39)		probably null	Het
Clvs2	C	T	10: 33,404,459 (GRCm39)	M252I	probably benign	Het
Cntnap5a	T	A	1: 116,112,057 (GRCm39)	L449Q	probably benign	Het
Col6a2	T	A	10: 76,450,368 (GRCm39)	I188F	probably damaging	Het
Cyp2c55	A	G	19: 39,026,587 (GRCm39)	D398G	probably benign	Het
Dennd1b	T	C	1: 139,071,626 (GRCm39)		probably benign	Het
Dop1a	T	A	9: 86,369,484 (GRCm39)	Y106N	probably damaging	Het
Dpy19l1	A	T	9: 24,334,493 (GRCm39)		probably null	Het
Extl3	C	T	14: 65,314,361 (GRCm39)	V274I	probably benign	Het
Fras1	G	A	5: 96,929,140 (GRCm39)	R3848H	probably damaging	Het
Gss	T	A	2: 155,423,871 (GRCm39)	D2V	probably damaging	Het
Hnrnpm	C	A	17: 33,868,876 (GRCm39)	R517L	probably damaging	Het
Ilvbl	G	A	10: 78,419,739 (GRCm39)	D548N	probably damaging	Het
Jmjd6	A	T	11: 116,733,202 (GRCm39)	D115E	possibly damaging	Het
Kidins220	T	A	12: 25,101,132 (GRCm39)	S1110R	possibly damaging	Het
Kmt2c	T	A	5: 25,481,227 (GRCm39)	I4784F	probably damaging	Het
Mrpl52	T	C	14: 54,664,494 (GRCm39)	V11A	possibly damaging	Het
Myo3b	A	G	2: 70,144,636 (GRCm39)	Y1036C	probably damaging	Het
Omp	T	C	7: 97,794,357 (GRCm39)	D90G	probably damaging	Het
Or6c2b	T	A	10: 128,947,893 (GRCm39)	M134L	probably benign	Het
Osmr	T	C	15: 6,854,086 (GRCm39)	I541V	probably benign	Het
Ppp2r1a	A	T	17: 21,181,840 (GRCm39)		probably benign	Het
Ptpn13	T	A	5: 103,665,437 (GRCm39)		probably null	Het
Rock2	C	A	12: 17,028,056 (GRCm39)	N1429K	probably benign	Het
Saxo4	A	T	19: 10,454,887 (GRCm39)		probably null	Het
Slc25a20	T	G	9: 108,559,198 (GRCm39)	M188R	possibly damaging	Het
Slc28a1	T	C	7: 80,818,816 (GRCm39)		probably benign	Het
Sult2a6	T	C	7: 13,988,634 (GRCm39)	Y42C	probably damaging	Het
Tgfb2	A	G	1: 186,436,784 (GRCm39)	V63A	probably benign	Het
Ugt2b38	A	T	5: 87,559,682 (GRCm39)	N403K	probably damaging	Het
Vmn2r29	A	G	7: 7,244,855 (GRCm39)	W340R	probably benign	Het
Wnt5a	C	T	14: 28,244,866 (GRCm39)	T351M	probably damaging	Het

Other mutations in Gm11437

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01354:Gm11437	APN	11	84,058,144 (GRCm39)	intron	probably benign
IGL02051:Gm11437	APN	11	84,043,592 (GRCm39)	missense	probably benign	0.00
IGL03184:Gm11437	APN	11	84,047,090 (GRCm39)	intron	probably benign
R0076:Gm11437	UTSW	11	84,039,462 (GRCm39)	missense	possibly damaging	0.91
R0076:Gm11437	UTSW	11	84,039,462 (GRCm39)	missense	possibly damaging	0.91
R1241:Gm11437	UTSW	11	84,055,454 (GRCm39)	missense	possibly damaging	0.93
R2135:Gm11437	UTSW	11	84,044,638 (GRCm39)	missense	probably damaging	0.97
R4065:Gm11437	UTSW	11	84,055,337 (GRCm39)	missense	probably benign	0.13
R4067:Gm11437	UTSW	11	84,055,337 (GRCm39)	missense	probably benign	0.13
R5356:Gm11437	UTSW	11	84,043,513 (GRCm39)	missense	possibly damaging	0.90
R6571:Gm11437	UTSW	11	84,047,038 (GRCm39)	missense	probably benign	0.13
R6594:Gm11437	UTSW	11	84,055,386 (GRCm39)	missense	probably null	0.03
R7173:Gm11437	UTSW	11	84,055,374 (GRCm39)	missense	probably benign	0.39
R7368:Gm11437	UTSW	11	84,058,298 (GRCm39)	intron	probably benign
R8918:Gm11437	UTSW	11	84,043,530 (GRCm39)	missense	probably benign	0.01
X0026:Gm11437	UTSW	11	84,056,153 (GRCm39)	missense	possibly damaging	0.92
X0028:Gm11437	UTSW	11	84,046,926 (GRCm39)	critical splice donor site	probably null

Posted On

2013-04-17