Incidental Mutation 'IGL02256:Mzf1'
ID |
286608 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Mzf1
|
Ensembl Gene |
ENSMUSG00000030380 |
Gene Name |
myeloid zinc finger 1 |
Synonyms |
Zfp98, Zfp121, Znf42, Mzf2 |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.181)
|
Stock # |
IGL02256
|
Quality Score |
|
Status
|
|
Chromosome |
7 |
Chromosomal Location |
12776230-12788691 bp(-) (GRCm39) |
Type of Mutation |
splice site |
DNA Base Change (assembly) |
A to G
at 12786664 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Ref Sequence |
ENSEMBL: ENSMUSP00000138387
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000069289]
[ENSMUST00000182087]
[ENSMUST00000182490]
[ENSMUST00000182515]
|
AlphaFold |
S4R1L6 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000069289
|
SMART Domains |
Protein: ENSMUSP00000069122 Gene: ENSMUSG00000030380
Domain | Start | End | E-Value | Type |
low complexity region
|
24 |
34 |
N/A |
INTRINSIC |
SCAN
|
41 |
153 |
1.18e-70 |
SMART |
ZnF_C2H2
|
357 |
379 |
4.87e-4 |
SMART |
ZnF_C2H2
|
385 |
407 |
1.95e-3 |
SMART |
ZnF_C2H2
|
413 |
435 |
1.18e-2 |
SMART |
ZnF_C2H2
|
441 |
463 |
8.6e-5 |
SMART |
ZnF_C2H2
|
486 |
508 |
1.79e-2 |
SMART |
ZnF_C2H2
|
514 |
536 |
7.15e-2 |
SMART |
ZnF_C2H2
|
542 |
564 |
8.47e-4 |
SMART |
ZnF_C2H2
|
570 |
592 |
2.79e-4 |
SMART |
ZnF_C2H2
|
598 |
620 |
1.6e-4 |
SMART |
ZnF_C2H2
|
626 |
648 |
1.67e-2 |
SMART |
ZnF_C2H2
|
654 |
676 |
3.44e-4 |
SMART |
ZnF_C2H2
|
682 |
704 |
2.84e-5 |
SMART |
ZnF_C2H2
|
710 |
732 |
2.4e-3 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000182087
|
SMART Domains |
Protein: ENSMUSP00000138163 Gene: ENSMUSG00000030380
Domain | Start | End | E-Value | Type |
low complexity region
|
24 |
34 |
N/A |
INTRINSIC |
SCAN
|
41 |
152 |
9.06e-58 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000182293
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000182490
|
SMART Domains |
Protein: ENSMUSP00000138271 Gene: ENSMUSG00000030380
Domain | Start | End | E-Value | Type |
low complexity region
|
103 |
113 |
N/A |
INTRINSIC |
SCAN
|
120 |
232 |
1.18e-70 |
SMART |
ZnF_C2H2
|
436 |
458 |
4.87e-4 |
SMART |
ZnF_C2H2
|
464 |
486 |
1.95e-3 |
SMART |
ZnF_C2H2
|
492 |
514 |
1.18e-2 |
SMART |
ZnF_C2H2
|
520 |
542 |
8.6e-5 |
SMART |
ZnF_C2H2
|
565 |
587 |
1.79e-2 |
SMART |
ZnF_C2H2
|
593 |
615 |
7.15e-2 |
SMART |
ZnF_C2H2
|
621 |
643 |
8.47e-4 |
SMART |
ZnF_C2H2
|
649 |
671 |
2.79e-4 |
SMART |
ZnF_C2H2
|
677 |
699 |
1.6e-4 |
SMART |
ZnF_C2H2
|
705 |
727 |
1.67e-2 |
SMART |
ZnF_C2H2
|
733 |
755 |
3.44e-4 |
SMART |
ZnF_C2H2
|
761 |
783 |
2.84e-5 |
SMART |
ZnF_C2H2
|
789 |
811 |
2.4e-3 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000182515
|
SMART Domains |
Protein: ENSMUSP00000138387 Gene: ENSMUSG00000030380
Domain | Start | End | E-Value | Type |
low complexity region
|
24 |
34 |
N/A |
INTRINSIC |
SCAN
|
41 |
153 |
1.18e-70 |
SMART |
ZnF_C2H2
|
357 |
379 |
4.87e-4 |
SMART |
ZnF_C2H2
|
385 |
407 |
1.95e-3 |
SMART |
ZnF_C2H2
|
413 |
435 |
1.18e-2 |
SMART |
ZnF_C2H2
|
441 |
463 |
8.6e-5 |
SMART |
ZnF_C2H2
|
486 |
508 |
1.79e-2 |
SMART |
ZnF_C2H2
|
514 |
536 |
7.15e-2 |
SMART |
ZnF_C2H2
|
542 |
564 |
8.47e-4 |
SMART |
ZnF_C2H2
|
570 |
592 |
2.79e-4 |
SMART |
ZnF_C2H2
|
598 |
620 |
1.6e-4 |
SMART |
ZnF_C2H2
|
626 |
648 |
1.67e-2 |
SMART |
ZnF_C2H2
|
654 |
676 |
3.44e-4 |
SMART |
ZnF_C2H2
|
682 |
704 |
2.84e-5 |
SMART |
ZnF_C2H2
|
710 |
732 |
2.4e-3 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000183176
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000210727
|
Coding Region Coverage |
|
Validation Efficiency |
|
MGI Phenotype |
PHENOTYPE: Homozygous mutants are prone to late-onset (>2 yr) neoplasias characterized by infiltration, enlargement and disruption of the liver by monomorphic cells of myeloid origin; hemopoietic progenitors show increased ability to sustain long-term hemopoiesis. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 35 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Ambra1 |
T |
A |
2: 91,599,399 (GRCm39) |
V173E |
possibly damaging |
Het |
Dennd4c |
A |
G |
4: 86,717,778 (GRCm39) |
T592A |
probably damaging |
Het |
Dhcr24 |
G |
A |
4: 106,429,517 (GRCm39) |
G197S |
probably damaging |
Het |
Fat1 |
A |
G |
8: 45,403,369 (GRCm39) |
Y40C |
probably damaging |
Het |
Fbxl17 |
A |
C |
17: 63,806,085 (GRCm39) |
C310G |
probably benign |
Het |
H2bc8 |
G |
T |
13: 23,755,609 (GRCm39) |
M1I |
probably null |
Het |
Hdac10 |
T |
C |
15: 89,010,097 (GRCm39) |
|
probably benign |
Het |
Mcm6 |
A |
G |
1: 128,263,465 (GRCm39) |
|
probably null |
Het |
Mrpl19 |
G |
A |
6: 81,941,300 (GRCm39) |
T87I |
probably benign |
Het |
Nhlrc2 |
A |
G |
19: 56,585,793 (GRCm39) |
E676G |
probably benign |
Het |
Notch3 |
T |
C |
17: 32,351,298 (GRCm39) |
D1899G |
probably damaging |
Het |
Nxph1 |
A |
G |
6: 9,247,185 (GRCm39) |
D52G |
probably benign |
Het |
Or10g9b |
A |
G |
9: 39,917,349 (GRCm39) |
F299L |
probably benign |
Het |
Or10j2 |
A |
T |
1: 173,098,194 (GRCm39) |
I151F |
probably benign |
Het |
Or2aj6 |
T |
C |
16: 19,443,756 (GRCm39) |
I31M |
probably benign |
Het |
Or2n1 |
G |
T |
17: 38,486,577 (GRCm39) |
V201L |
probably benign |
Het |
Or8b3b |
A |
T |
9: 38,584,776 (GRCm39) |
M1K |
probably null |
Het |
Or8b49 |
G |
A |
9: 38,505,840 (GRCm39) |
V108I |
probably benign |
Het |
Pax6 |
T |
C |
2: 105,515,115 (GRCm39) |
V54A |
probably benign |
Het |
Pbx1 |
A |
T |
1: 168,011,171 (GRCm39) |
H376Q |
possibly damaging |
Het |
Prpf4b |
T |
A |
13: 35,083,861 (GRCm39) |
C877S |
probably damaging |
Het |
Robo3 |
A |
G |
9: 37,336,649 (GRCm39) |
L373P |
probably damaging |
Het |
Samd9l |
G |
A |
6: 3,376,197 (GRCm39) |
R355W |
probably damaging |
Het |
Smarce1 |
A |
T |
11: 99,110,206 (GRCm39) |
N127K |
possibly damaging |
Het |
Sptbn1 |
T |
C |
11: 30,070,990 (GRCm39) |
I1511V |
probably benign |
Het |
Stab1 |
C |
T |
14: 30,863,549 (GRCm39) |
R2071H |
probably damaging |
Het |
Svep1 |
A |
T |
4: 58,070,311 (GRCm39) |
C2492S |
possibly damaging |
Het |
Tbr1 |
C |
A |
2: 61,635,218 (GRCm39) |
T56N |
probably damaging |
Het |
Thoc2l |
T |
A |
5: 104,668,149 (GRCm39) |
Y890* |
probably null |
Het |
Tlr6 |
T |
C |
5: 65,112,287 (GRCm39) |
T207A |
probably benign |
Het |
Tmem241 |
A |
G |
18: 12,246,489 (GRCm39) |
W54R |
probably damaging |
Het |
Tmem87a |
A |
G |
2: 120,208,377 (GRCm39) |
V326A |
probably damaging |
Het |
Trappc14 |
C |
A |
5: 138,258,577 (GRCm39) |
D557Y |
probably damaging |
Het |
Uroc1 |
A |
G |
6: 90,323,669 (GRCm39) |
D372G |
possibly damaging |
Het |
Zc3h7a |
A |
C |
16: 10,965,140 (GRCm39) |
S664R |
probably benign |
Het |
|
Other mutations in Mzf1 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00418:Mzf1
|
APN |
7 |
12,778,543 (GRCm39) |
missense |
possibly damaging |
0.85 |
IGL01728:Mzf1
|
APN |
7 |
12,785,654 (GRCm39) |
splice site |
probably benign |
|
IGL02194:Mzf1
|
APN |
7 |
12,777,647 (GRCm39) |
missense |
possibly damaging |
0.53 |
IGL02584:Mzf1
|
APN |
7 |
12,786,744 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL02678:Mzf1
|
APN |
7 |
12,786,836 (GRCm39) |
missense |
probably benign |
0.00 |
R0903:Mzf1
|
UTSW |
7 |
12,786,698 (GRCm39) |
missense |
possibly damaging |
0.82 |
R0904:Mzf1
|
UTSW |
7 |
12,786,698 (GRCm39) |
missense |
possibly damaging |
0.82 |
R0905:Mzf1
|
UTSW |
7 |
12,786,698 (GRCm39) |
missense |
possibly damaging |
0.82 |
R1128:Mzf1
|
UTSW |
7 |
12,786,698 (GRCm39) |
missense |
possibly damaging |
0.82 |
R1131:Mzf1
|
UTSW |
7 |
12,786,698 (GRCm39) |
missense |
possibly damaging |
0.82 |
R1280:Mzf1
|
UTSW |
7 |
12,787,010 (GRCm39) |
missense |
probably damaging |
0.96 |
R1400:Mzf1
|
UTSW |
7 |
12,786,698 (GRCm39) |
missense |
possibly damaging |
0.82 |
R1640:Mzf1
|
UTSW |
7 |
12,777,197 (GRCm39) |
makesense |
probably null |
|
R1687:Mzf1
|
UTSW |
7 |
12,786,698 (GRCm39) |
missense |
possibly damaging |
0.82 |
R4014:Mzf1
|
UTSW |
7 |
12,777,883 (GRCm39) |
missense |
possibly damaging |
0.47 |
R4721:Mzf1
|
UTSW |
7 |
12,777,448 (GRCm39) |
missense |
possibly damaging |
0.53 |
R4721:Mzf1
|
UTSW |
7 |
12,777,223 (GRCm39) |
missense |
possibly damaging |
0.52 |
R5511:Mzf1
|
UTSW |
7 |
12,785,526 (GRCm39) |
missense |
possibly damaging |
0.95 |
R5611:Mzf1
|
UTSW |
7 |
12,778,554 (GRCm39) |
utr 3 prime |
probably benign |
|
R5728:Mzf1
|
UTSW |
7 |
12,777,985 (GRCm39) |
missense |
probably benign |
0.00 |
R5868:Mzf1
|
UTSW |
7 |
12,787,116 (GRCm39) |
missense |
probably benign |
0.00 |
R6283:Mzf1
|
UTSW |
7 |
12,787,296 (GRCm39) |
intron |
probably benign |
|
R7059:Mzf1
|
UTSW |
7 |
12,786,985 (GRCm39) |
missense |
probably damaging |
0.96 |
R7066:Mzf1
|
UTSW |
7 |
12,777,490 (GRCm39) |
missense |
possibly damaging |
0.92 |
R7763:Mzf1
|
UTSW |
7 |
12,778,018 (GRCm39) |
missense |
probably damaging |
1.00 |
R8157:Mzf1
|
UTSW |
7 |
12,778,279 (GRCm39) |
missense |
probably damaging |
1.00 |
R8870:Mzf1
|
UTSW |
7 |
12,786,836 (GRCm39) |
missense |
probably benign |
0.00 |
R9063:Mzf1
|
UTSW |
7 |
12,787,005 (GRCm39) |
missense |
probably damaging |
1.00 |
R9113:Mzf1
|
UTSW |
7 |
12,778,279 (GRCm39) |
missense |
probably damaging |
1.00 |
R9252:Mzf1
|
UTSW |
7 |
12,777,647 (GRCm39) |
missense |
probably benign |
0.33 |
R9289:Mzf1
|
UTSW |
7 |
12,785,534 (GRCm39) |
missense |
probably benign |
0.02 |
R9792:Mzf1
|
UTSW |
7 |
12,786,131 (GRCm39) |
missense |
probably benign |
0.02 |
|
Posted On |
2015-04-16 |