Incidental Mutation 'IGL02382:Tnip3'
| ID |
291427 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Tnip3
|
| Ensembl Gene |
ENSMUSG00000044162 |
| Gene Name |
TNFAIP3 interacting protein 3 |
| Synonyms |
9030611K07Rik |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL02382
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
6 |
| Chromosomal Location |
65567382-65611024 bp(+) (GRCm39) |
| Type of Mutation |
critical splice donor site (2 bp from exon) |
| DNA Base Change (assembly) |
T to C
at 65591779 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000148446
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000114236]
[ENSMUST00000212375]
[ENSMUST00000212402]
|
| AlphaFold |
A0A1D5RMN0 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000114236
|
| SMART Domains |
Protein: ENSMUSP00000109874
Gene: ENSMUSG00000044162
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
20 |
145 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000212375
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000212402
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele are viable and fertile and do not develop spontaneous inflammatory or autoimmune disease; mutant macrophages exhibit normal responses to IL-10 and LPS. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 28 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aim2 |
A |
G |
1: 173,287,315 (GRCm39) |
|
probably null |
Het |
| Aoc2 |
T |
C |
11: 101,217,498 (GRCm39) |
L527P |
probably damaging |
Het |
| Arhgef15 |
C |
A |
11: 68,844,856 (GRCm39) |
R247L |
probably damaging |
Het |
| Armcx2 |
T |
C |
X: 133,706,416 (GRCm39) |
T406A |
probably benign |
Het |
| Armcx5 |
T |
C |
X: 134,647,577 (GRCm39) |
F551S |
probably damaging |
Het |
| Ccrl2 |
T |
C |
9: 110,884,947 (GRCm39) |
K184E |
probably benign |
Het |
| Cenpe |
A |
G |
3: 134,953,147 (GRCm39) |
I1534V |
probably benign |
Het |
| Cflar |
T |
A |
1: 58,791,840 (GRCm39) |
I381K |
probably benign |
Het |
| Crb1 |
T |
A |
1: 139,165,352 (GRCm39) |
N924I |
probably damaging |
Het |
| Crebbp |
A |
G |
16: 3,925,934 (GRCm39) |
V729A |
probably damaging |
Het |
| Dab2 |
T |
A |
15: 6,466,468 (GRCm39) |
V615D |
possibly damaging |
Het |
| Edrf1 |
T |
C |
7: 133,252,344 (GRCm39) |
|
probably benign |
Het |
| Ep400 |
G |
A |
5: 110,849,594 (GRCm39) |
T1409I |
unknown |
Het |
| Gm14406 |
C |
A |
2: 177,260,988 (GRCm39) |
|
probably benign |
Het |
| Kptn |
T |
A |
7: 15,857,945 (GRCm39) |
S258T |
probably benign |
Het |
| Mbnl1 |
G |
T |
3: 60,532,563 (GRCm39) |
E291* |
probably null |
Het |
| Mcm4 |
A |
T |
16: 15,442,602 (GRCm39) |
L843Q |
probably damaging |
Het |
| Mgrn1 |
A |
G |
16: 4,740,482 (GRCm39) |
N274D |
probably damaging |
Het |
| Or13a21 |
T |
A |
7: 139,999,516 (GRCm39) |
T57S |
possibly damaging |
Het |
| Or8d1 |
G |
A |
9: 38,766,364 (GRCm39) |
G2D |
probably benign |
Het |
| Phactr4 |
A |
T |
4: 132,098,152 (GRCm39) |
V335E |
probably damaging |
Het |
| Ptgr2 |
T |
C |
12: 84,360,722 (GRCm39) |
S331P |
probably damaging |
Het |
| Ranbp9 |
T |
C |
13: 43,589,622 (GRCm39) |
|
probably null |
Het |
| Setd5 |
A |
G |
6: 113,120,601 (GRCm39) |
T937A |
probably benign |
Het |
| Slc27a4 |
C |
T |
2: 29,699,855 (GRCm39) |
R265C |
probably damaging |
Het |
| Srrm1 |
G |
A |
4: 135,052,415 (GRCm39) |
P658L |
unknown |
Het |
| Tenm3 |
A |
G |
8: 48,688,511 (GRCm39) |
Y2359H |
probably damaging |
Het |
| Zfc3h1 |
C |
T |
10: 115,252,781 (GRCm39) |
Q1365* |
probably null |
Het |
|
| Other mutations in Tnip3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01736:Tnip3
|
APN |
6 |
65,573,107 (GRCm39) |
splice site |
probably benign |
|
|
IGL02054:Tnip3
|
APN |
6 |
65,567,595 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
nickle_nip
|
UTSW |
6 |
65,591,779 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0671:Tnip3
|
UTSW |
6 |
65,574,347 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1344:Tnip3
|
UTSW |
6 |
65,574,413 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1418:Tnip3
|
UTSW |
6 |
65,574,413 (GRCm39) |
missense |
probably benign |
0.44 |
|
R3748:Tnip3
|
UTSW |
6 |
65,591,747 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3953:Tnip3
|
UTSW |
6 |
65,574,379 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R3955:Tnip3
|
UTSW |
6 |
65,574,379 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R5775:Tnip3
|
UTSW |
6 |
65,591,741 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5930:Tnip3
|
UTSW |
6 |
65,582,937 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6108:Tnip3
|
UTSW |
6 |
65,502,395 (GRCm39) |
splice site |
probably null |
|
|
R6495:Tnip3
|
UTSW |
6 |
65,582,846 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7210:Tnip3
|
UTSW |
6 |
65,570,495 (GRCm39) |
nonsense |
probably null |
|
|
R7956:Tnip3
|
UTSW |
6 |
65,591,779 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7983:Tnip3
|
UTSW |
6 |
65,515,630 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8267:Tnip3
|
UTSW |
6 |
65,582,826 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R8957:Tnip3
|
UTSW |
6 |
65,582,843 (GRCm39) |
missense |
probably benign |
0.05 |
|
Z1177:Tnip3
|
UTSW |
6 |
65,591,717 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
| Posted On |
2015-04-16 |
Incidental Mutation