Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02388:Zfp605'

291640

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp605

Ensembl Gene

ENSMUSG00000023284

Gene Name

zinc finger protein 605

Synonyms

A830023I12Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.079) question?

Stock #

IGL02388

Quality Score

Status

Chromosome

Chromosomal Location

110257958-110277660 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 110275506 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Asparagine at position 208 (I208N)

Ref Sequence

ENSEMBL: ENSMUSP00000108147 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000086686] [ENSMUST00000112528] [ENSMUST00000147631]

AlphaFold

E9QAH2

Predicted Effect

possibly damaging
Transcript: ENSMUST00000086686
AA Change: I208N

PolyPhen 2 Score 0.950 (Sensitivity: 0.79; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000083891
Gene: ENSMUSG00000023284
AA Change: I208N

Domain	Start	End	E-Value	Type
KRAB	6	66	3.75e-28	SMART
low complexity region	147	159	N/A	INTRINSIC
ZnF_C2H2	200	222	1.36e-2	SMART
ZnF_C2H2	228	250	4.38e1	SMART
ZnF_C2H2	305	327	1.18e-2	SMART
ZnF_C2H2	333	355	5.14e-3	SMART
ZnF_C2H2	361	383	9.73e-4	SMART
ZnF_C2H2	389	411	4.99e1	SMART
ZnF_C2H2	443	465	5.4e1	SMART
ZnF_C2H2	471	493	1.3e-4	SMART
ZnF_C2H2	499	521	4.24e-4	SMART
ZnF_C2H2	527	549	1.95e-3	SMART
ZnF_C2H2	555	577	2.09e-3	SMART
ZnF_C2H2	583	605	1.2e-3	SMART
ZnF_C2H2	611	633	1.79e-2	SMART
ZnF_C2H2	639	661	2.53e-2	SMART
ZnF_C2H2	667	689	2.09e-3	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000112528
AA Change: I208N

PolyPhen 2 Score 0.950 (Sensitivity: 0.79; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000108147
Gene: ENSMUSG00000023284
AA Change: I208N

Domain	Start	End	E-Value	Type
KRAB	6	66	3.75e-28	SMART
low complexity region	147	159	N/A	INTRINSIC
ZnF_C2H2	200	222	1.36e-2	SMART
ZnF_C2H2	228	250	4.38e1	SMART
ZnF_C2H2	305	327	1.18e-2	SMART
ZnF_C2H2	333	355	5.14e-3	SMART
ZnF_C2H2	361	383	9.73e-4	SMART
ZnF_C2H2	389	411	4.99e1	SMART
ZnF_C2H2	443	465	5.4e1	SMART
ZnF_C2H2	471	493	1.3e-4	SMART
ZnF_C2H2	499	521	4.24e-4	SMART
ZnF_C2H2	527	549	1.95e-3	SMART
ZnF_C2H2	555	577	2.09e-3	SMART
ZnF_C2H2	583	605	1.2e-3	SMART
ZnF_C2H2	611	633	1.79e-2	SMART
ZnF_C2H2	639	661	2.53e-2	SMART
ZnF_C2H2	667	689	2.09e-3	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000144089

Predicted Effect

probably benign
Transcript: ENSMUST00000147631

SMART Domains

Protein: ENSMUSP00000122236
Gene: ENSMUSG00000023284

Domain	Start	End	E-Value	Type
KRAB	6	66	3.75e-28	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930597O21Rik	A	T	6: 66,873,097 (GRCm39)		probably benign	Het
Abca8a	A	G	11: 109,969,641 (GRCm39)		probably benign	Het
Asphd1	A	T	7: 126,545,884 (GRCm39)		probably benign	Het
Ccdc77	G	A	6: 120,308,858 (GRCm39)	A301V	probably benign	Het
Cep350	G	T	1: 155,829,499 (GRCm39)	T135K	probably benign	Het
Chrna7	A	T	7: 62,757,439 (GRCm39)	D153E	probably damaging	Het
Clec4b2	G	T	6: 123,179,187 (GRCm39)		probably null	Het
Cyp2c67	T	C	19: 39,631,799 (GRCm39)	N133D	probably benign	Het
Dglucy	T	C	12: 100,823,257 (GRCm39)	I484T	probably damaging	Het
Dtna	G	T	18: 23,730,571 (GRCm39)	M319I	probably benign	Het
E2f5	T	A	3: 14,653,340 (GRCm39)	M152K	probably benign	Het
Emsy	A	T	7: 98,290,873 (GRCm39)	M58K	probably damaging	Het
Epha1	A	G	6: 42,341,950 (GRCm39)	Y367H	probably damaging	Het
Etv1	A	G	12: 38,831,798 (GRCm39)	S32G	possibly damaging	Het
Fam114a1	A	T	5: 65,166,323 (GRCm39)		probably benign	Het
Fbxo30	T	A	10: 11,166,122 (GRCm39)	N281K	probably benign	Het
Galnt12	G	T	4: 47,117,941 (GRCm39)	R412L	probably damaging	Het
Gm5786	T	A	12: 59,128,382 (GRCm39)		noncoding transcript	Het
Gm9845	T	C	3: 39,412,616 (GRCm39)		noncoding transcript	Het
Hecw2	A	G	1: 53,964,858 (GRCm39)	V656A	probably benign	Het
Hpse2	A	T	19: 43,282,692 (GRCm39)	V187D	probably damaging	Het
Itsn2	T	A	12: 4,679,557 (GRCm39)	M122K	possibly damaging	Het
Kcnj11	A	G	7: 45,749,213 (GRCm39)	S37P	probably benign	Het
Kif13b	T	C	14: 65,037,807 (GRCm39)	I1491T	probably damaging	Het
Krt36	T	A	11: 99,995,990 (GRCm39)	K145*	probably null	Het
Loxhd1	A	G	18: 77,456,833 (GRCm39)	I499V	probably benign	Het
Map3k4	G	T	17: 12,490,497 (GRCm39)	N311K	probably damaging	Het
Mical2	C	A	7: 111,934,620 (GRCm39)	H880N	probably benign	Het
Myo1d	A	T	11: 80,528,823 (GRCm39)	C666*	probably null	Het
Nlrx1	C	T	9: 44,175,302 (GRCm39)	R158H	probably benign	Het
Or10ag53	T	A	2: 87,082,295 (GRCm39)	Y5N	probably benign	Het
Or10q1	C	A	19: 13,726,994 (GRCm39)	H175N	possibly damaging	Het
Or13a17	A	G	7: 140,271,024 (GRCm39)	T69A	probably benign	Het
Or1e21	A	T	11: 73,344,106 (GRCm39)	L311I	probably benign	Het
Or4a78	T	C	2: 89,497,316 (GRCm39)	S305G	probably benign	Het
Pdgfrl	A	G	8: 41,430,094 (GRCm39)	R154G	probably benign	Het
Pitpnb	T	C	5: 111,478,699 (GRCm39)	F7S	possibly damaging	Het
Ppm1n	G	A	7: 19,013,097 (GRCm39)	R285C	probably damaging	Het
Prdm11	A	T	2: 92,805,957 (GRCm39)	I331N	possibly damaging	Het
Ptprb	C	T	10: 116,203,426 (GRCm39)	P2066L	probably damaging	Het
Ric8b	T	C	10: 84,828,135 (GRCm39)		probably benign	Het
Setx	A	G	2: 29,063,665 (GRCm39)	I2320M	probably damaging	Het
Skil	C	A	3: 31,165,787 (GRCm39)	S368*	probably null	Het
Slc1a5	G	T	7: 16,519,644 (GRCm39)		probably null	Het
Trpm7	A	C	2: 126,661,811 (GRCm39)	V1079G	possibly damaging	Het
Tulp1	A	G	17: 28,577,633 (GRCm39)	F2L	probably damaging	Het
Ulbp3	A	T	10: 3,075,050 (GRCm39)		noncoding transcript	Het
Zbtb17	A	G	4: 141,189,224 (GRCm39)	Y48C	probably damaging	Het

Other mutations in Zfp605

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0010:Zfp605	UTSW	5	110,275,400 (GRCm39)	missense	probably benign	0.03
R0357:Zfp605	UTSW	5	110,272,245 (GRCm39)	missense	probably benign
R0383:Zfp605	UTSW	5	110,276,720 (GRCm39)	missense	probably damaging	1.00
R1017:Zfp605	UTSW	5	110,275,860 (GRCm39)	missense	probably benign	0.42
R1663:Zfp605	UTSW	5	110,275,451 (GRCm39)	missense	probably benign	0.02
R1688:Zfp605	UTSW	5	110,276,907 (GRCm39)	missense	possibly damaging	0.83
R1752:Zfp605	UTSW	5	110,271,639 (GRCm39)	missense	probably damaging	1.00
R1994:Zfp605	UTSW	5	110,275,418 (GRCm39)	missense	probably damaging	1.00
R2173:Zfp605	UTSW	5	110,275,323 (GRCm39)	missense	probably benign	0.00
R3740:Zfp605	UTSW	5	110,276,564 (GRCm39)	missense	probably damaging	1.00
R3742:Zfp605	UTSW	5	110,276,564 (GRCm39)	missense	probably damaging	1.00
R3981:Zfp605	UTSW	5	110,275,604 (GRCm39)	missense	probably damaging	1.00
R4095:Zfp605	UTSW	5	110,275,602 (GRCm39)	missense	probably damaging	1.00
R4349:Zfp605	UTSW	5	110,276,552 (GRCm39)	missense	probably damaging	1.00
R4669:Zfp605	UTSW	5	110,275,227 (GRCm39)	missense	possibly damaging	0.94
R4914:Zfp605	UTSW	5	110,275,567 (GRCm39)	nonsense	probably null
R4994:Zfp605	UTSW	5	110,275,352 (GRCm39)	missense	probably damaging	1.00
R6672:Zfp605	UTSW	5	110,275,863 (GRCm39)	missense	probably damaging	1.00
R6814:Zfp605	UTSW	5	110,275,311 (GRCm39)	missense	probably benign	0.00
R6872:Zfp605	UTSW	5	110,275,311 (GRCm39)	missense	probably benign	0.00
R7251:Zfp605	UTSW	5	110,275,826 (GRCm39)	missense	probably damaging	1.00
R7395:Zfp605	UTSW	5	110,259,885 (GRCm39)	start gained	probably benign
R7560:Zfp605	UTSW	5	110,275,157 (GRCm39)	nonsense	probably null
R7623:Zfp605	UTSW	5	110,275,386 (GRCm39)	missense	probably benign	0.03
R7965:Zfp605	UTSW	5	110,275,316 (GRCm39)	missense	probably benign	0.00
R7999:Zfp605	UTSW	5	110,276,300 (GRCm39)	missense	probably damaging	1.00
R8307:Zfp605	UTSW	5	110,276,063 (GRCm39)	missense	probably damaging	1.00
R8355:Zfp605	UTSW	5	110,259,848 (GRCm39)	start gained	probably benign
R8455:Zfp605	UTSW	5	110,259,848 (GRCm39)	start gained	probably benign
X0063:Zfp605	UTSW	5	110,271,714 (GRCm39)	missense	probably damaging	0.99

Posted On

2015-04-16