Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02427:Cfap77'

292961

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cfap77

Ensembl Gene

ENSMUSG00000079502

Gene Name

cilia and flagella associated protein 77

Synonyms

LOC329375, 1700101E01Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.099) question?

Stock #

IGL02427

Quality Score

Status

Chromosome

Chromosomal Location

28845493-28945078 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 28845592 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Stop codon at position 258 (C258*)

Ref Sequence

ENSEMBL: ENSMUSP00000125742 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000157048] [ENSMUST00000189027] [ENSMUST00000189711]

AlphaFold

A0A087WRI3

Predicted Effect

probably null
Transcript: ENSMUST00000157048
AA Change: C258*

SMART Domains

Protein: ENSMUSP00000125742
Gene: ENSMUSG00000079502
AA Change: C258*

Domain	Start	End	E-Value	Type
Pfam:DUF4483	54	204	1.1e-53	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000189027

Predicted Effect

probably benign
Transcript: ENSMUST00000189711

SMART Domains

Protein: ENSMUSP00000140645
Gene: ENSMUSG00000079502

Domain	Start	End	E-Value	Type
Pfam:DUF4483	52	250	9.4e-65	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000190049

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A930011G23Rik	C	T	5: 99,381,829 (GRCm39)	G311D	probably damaging	Het
Ablim1	A	T	19: 57,068,312 (GRCm39)		probably benign	Het
Adgrg2	T	C	X: 159,274,400 (GRCm39)	F863S	probably damaging	Het
B3galt2	A	T	1: 143,522,254 (GRCm39)	H130L	probably benign	Het
Bbs2	G	A	8: 94,807,746 (GRCm39)	P378S	possibly damaging	Het
Ccdc154	A	T	17: 25,390,731 (GRCm39)		probably null	Het
Ccdc88c	C	T	12: 100,887,851 (GRCm39)	C1543Y	probably damaging	Het
Cdcp3	T	A	7: 130,846,517 (GRCm39)	V647E	probably damaging	Het
Cpsf4l	T	G	11: 113,600,324 (GRCm39)		probably benign	Het
Csrnp3	G	A	2: 65,708,380 (GRCm39)		probably benign	Het
Cul9	G	A	17: 46,813,558 (GRCm39)	T2305I	possibly damaging	Het
Cwf19l1	G	A	19: 44,121,462 (GRCm39)	Q29*	probably null	Het
Cwf19l2	G	T	9: 3,456,817 (GRCm39)	V717L	probably benign	Het
Cyp1a1	A	G	9: 57,607,858 (GRCm39)	Y162C	probably damaging	Het
Dlg5	T	C	14: 24,216,275 (GRCm39)	D589G	probably damaging	Het
Dmbt1	G	T	7: 130,689,815 (GRCm39)		probably null	Het
Dtna	T	C	18: 23,784,595 (GRCm39)	Y705H	possibly damaging	Het
Fancd2	T	A	6: 113,526,313 (GRCm39)		probably null	Het
Frem2	T	A	3: 53,443,184 (GRCm39)	N2527Y	probably damaging	Het
Gm7694	T	C	1: 170,130,113 (GRCm39)	D95G	probably benign	Het
Haus5	T	C	7: 30,361,196 (GRCm39)	T115A	probably benign	Het
Kdm3a	A	T	6: 71,569,184 (GRCm39)		probably benign	Het
Klra6	T	C	6: 129,993,680 (GRCm39)	D197G	possibly damaging	Het
Lap3	T	C	5: 45,668,475 (GRCm39)	V429A	probably damaging	Het
Mroh2b	G	T	15: 4,981,042 (GRCm39)		probably benign	Het
Myh9	T	A	15: 77,660,004 (GRCm39)	Q88L	probably damaging	Het
Myo5a	T	C	9: 75,083,900 (GRCm39)		probably benign	Het
Negr1	C	T	3: 156,267,827 (GRCm39)		probably benign	Het
Niban1	A	T	1: 151,593,025 (GRCm39)	D570V	probably damaging	Het
Nlrp9b	T	G	7: 19,776,426 (GRCm39)	C337W	probably damaging	Het
Obscn	A	T	11: 58,957,988 (GRCm39)	C3780S	probably damaging	Het
Or1e19	A	T	11: 73,316,487 (GRCm39)	F107L	probably damaging	Het
Piwil2	T	A	14: 70,635,583 (GRCm39)		probably benign	Het
Ppp6r3	T	C	19: 3,516,580 (GRCm39)	S213G	probably null	Het
Pxdn	T	A	12: 30,034,531 (GRCm39)	C39S	probably damaging	Het
Raf1	T	C	6: 115,608,288 (GRCm39)	N241S	probably benign	Het
Rapgef3	A	T	15: 97,645,017 (GRCm39)		probably null	Het
Rhox2h	C	T	X: 36,854,526 (GRCm39)	G72D	probably benign	Het
Sbf1	T	C	15: 89,190,188 (GRCm39)		probably benign	Het
Sema5a	T	C	15: 32,673,690 (GRCm39)		probably benign	Het
Setbp1	T	C	18: 78,900,688 (GRCm39)	D993G	probably damaging	Het
Slc5a4b	A	T	10: 75,894,713 (GRCm39)	C598S	possibly damaging	Het
Sorl1	T	C	9: 41,952,986 (GRCm39)	D685G	probably damaging	Het
Sulf2	C	T	2: 165,931,218 (GRCm39)	R263H	probably damaging	Het
Tbx22	C	A	X: 106,724,777 (GRCm39)	P17T	probably damaging	Het
Tspoap1	A	T	11: 87,653,341 (GRCm39)	T136S	probably benign	Het
Tyw5	T	C	1: 57,427,884 (GRCm39)	E240G	possibly damaging	Het
Umodl1	C	T	17: 31,187,415 (GRCm39)		probably benign	Het
Vmn1r60	T	C	7: 5,547,780 (GRCm39)	T107A	probably damaging	Het
Zbbx	T	C	3: 75,046,905 (GRCm39)	T121A	probably benign	Het
Zbtb11	A	G	16: 55,802,713 (GRCm39)	D241G	possibly damaging	Het
Zfp445	T	C	9: 122,681,295 (GRCm39)	H882R	probably benign	Het
Zscan30	T	C	18: 24,104,533 (GRCm39)		noncoding transcript	Het

Other mutations in Cfap77

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0094:Cfap77	UTSW	2	28,874,446 (GRCm39)	missense	probably damaging	1.00
R1164:Cfap77	UTSW	2	28,852,700 (GRCm39)	missense	probably damaging	1.00
R3081:Cfap77	UTSW	2	28,852,662 (GRCm39)	missense	probably damaging	1.00
R4732:Cfap77	UTSW	2	28,874,400 (GRCm39)	missense	probably benign	0.17
R4733:Cfap77	UTSW	2	28,874,400 (GRCm39)	missense	probably benign	0.17
R4831:Cfap77	UTSW	2	28,875,844 (GRCm39)	missense	probably benign	0.00
R6772:Cfap77	UTSW	2	28,944,951 (GRCm39)	missense	probably damaging	1.00
R7170:Cfap77	UTSW	2	28,875,854 (GRCm39)	nonsense	probably null
R7466:Cfap77	UTSW	2	28,845,625 (GRCm39)	missense	probably benign
R9764:Cfap77	UTSW	2	28,852,741 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16