Incidental Mutation 'IGL02436:Or10ad1b'
ID 293269
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or10ad1b
Ensembl Gene ENSMUSG00000059460
Gene Name olfactory receptor family 10 subfamily AD member 1B
Synonyms Olfr286, GA_x6K02T2NBG7-5528233-5529186, EG629524, MOR286-2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.089) question?
Stock # IGL02436
Quality Score
Status
Chromosome 15
Chromosomal Location 98124556-98132331 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to T at 98125171 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 118 (C118*)
Ref Sequence ENSEMBL: ENSMUSP00000154542 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073612] [ENSMUST00000205305]
AlphaFold A0A2I3BRI6
Predicted Effect probably null
Transcript: ENSMUST00000073612
AA Change: C120*
SMART Domains Protein: ENSMUSP00000073296
Gene: ENSMUSG00000059460
AA Change: C120*

DomainStartEndE-ValueType
Pfam:7tm_4 37 313 2.6e-52 PFAM
Pfam:7tm_1 47 296 2.4e-23 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000073612
AA Change: C120*
Predicted Effect probably null
Transcript: ENSMUST00000205305
AA Change: C118*
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205393
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206621
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 22 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Carm1 A T 9: 21,490,758 (GRCm39) R209W probably damaging Het
Clec4a2 A G 6: 123,117,637 (GRCm39) D185G possibly damaging Het
Csgalnact1 C A 8: 68,854,144 (GRCm39) G219V probably damaging Het
Dyrk3 A G 1: 131,056,602 (GRCm39) S524P probably benign Het
Gm17175 A T 14: 51,807,108 (GRCm39) probably benign Het
Hdx A T X: 110,510,445 (GRCm39) D512E probably damaging Het
Hs6st2 T G X: 50,768,891 (GRCm39) T275P possibly damaging Het
Hus1 T C 11: 8,956,057 (GRCm39) I159V possibly damaging Het
Lrrc37a T C 11: 103,389,003 (GRCm39) T2141A unknown Het
Ncoa7 A T 10: 30,570,143 (GRCm39) I272N probably damaging Het
P3h2 T C 16: 25,815,950 (GRCm39) K188E probably benign Het
Pcsk5 A G 19: 17,542,072 (GRCm39) probably null Het
Pramel13 G T 4: 144,119,539 (GRCm39) P343T possibly damaging Het
Scn1a G A 2: 66,181,497 (GRCm39) P9S probably benign Het
Slc7a9 C A 7: 35,156,478 (GRCm39) L307I probably benign Het
Srebf2 G A 15: 82,081,928 (GRCm39) G87S probably benign Het
Srrm1 G A 4: 135,052,415 (GRCm39) P658L unknown Het
Tent5c C A 3: 100,379,823 (GRCm39) R311L probably benign Het
Tex30 T C 1: 44,127,665 (GRCm39) probably null Het
Thoc2l T A 5: 104,669,021 (GRCm39) I1181K probably benign Het
Tnrc6a C T 7: 122,783,438 (GRCm39) R970* probably null Het
Vgll2 A T 10: 51,901,318 (GRCm39) R83* probably null Het
Other mutations in Or10ad1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02850:Or10ad1b APN 15 98,125,232 (GRCm39) missense probably benign 0.01
R1833:Or10ad1b UTSW 15 98,124,846 (GRCm39) missense probably damaging 1.00
R3879:Or10ad1b UTSW 15 98,125,085 (GRCm39) missense probably damaging 0.98
R4854:Or10ad1b UTSW 15 98,125,425 (GRCm39) missense possibly damaging 0.93
R4866:Or10ad1b UTSW 15 98,125,371 (GRCm39) missense probably damaging 1.00
R5076:Or10ad1b UTSW 15 98,124,642 (GRCm39) missense probably damaging 1.00
R5886:Or10ad1b UTSW 15 98,124,672 (GRCm39) missense possibly damaging 0.83
R7090:Or10ad1b UTSW 15 98,125,083 (GRCm39) missense probably benign 0.00
R9378:Or10ad1b UTSW 15 98,124,920 (GRCm39) missense possibly damaging 0.94
R9405:Or10ad1b UTSW 15 98,124,912 (GRCm39) missense possibly damaging 0.88
R9715:Or10ad1b UTSW 15 98,124,902 (GRCm39) missense probably damaging 0.99
Posted On 2015-04-16