Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02394:Gpr37l1'

293928

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gpr37l1

Ensembl Gene

ENSMUSG00000026424

Gene Name

G protein-coupled receptor 37-like 1

Synonyms

D0Kist8, CAG-18

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.063) question?

Stock #

IGL02394

Quality Score

Status

Chromosome

Chromosomal Location

135087988-135095419 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 135094746 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 166 (N166S)

Ref Sequence

ENSEMBL: ENSMUSP00000027682 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000027682]

AlphaFold

Q99JG2

Predicted Effect

probably damaging
Transcript: ENSMUST00000027682
AA Change: N166S

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000027682
Gene: ENSMUSG00000026424
AA Change: N166S

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:7tm_1	147	416	4.4e-25	PFAM
low complexity region	430	439	N/A	INTRINSIC
low complexity region	442	453	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele may exhibit no abnormal phenotype, precocious cerebellum development and improved motor functions or abnormal blood pressure in female mice. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akt3	G	A	1: 176,886,985 (GRCm39)	T288M	probably damaging	Het
Baat	A	T	4: 49,489,812 (GRCm39)		probably benign	Het
Bclaf3	A	G	X: 158,338,485 (GRCm39)	Y444C	probably damaging	Het
Bcs1l	A	G	1: 74,629,459 (GRCm39)	T166A	probably damaging	Het
Cep135	C	T	5: 76,779,318 (GRCm39)	T776I	probably benign	Het
Clasrp	A	G	7: 19,337,179 (GRCm39)	L12P	probably damaging	Het
Csgalnact1	C	A	8: 68,854,144 (GRCm39)	G219V	probably damaging	Het
Cyp4f15	A	G	17: 32,911,609 (GRCm39)	I164V	possibly damaging	Het
Eps15	T	A	4: 109,170,162 (GRCm39)	L155M	probably damaging	Het
Fbxl20	G	A	11: 98,004,082 (GRCm39)	R69W	probably damaging	Het
Galnt9	A	G	5: 110,763,365 (GRCm39)	M457V	probably damaging	Het
Gemin2	T	A	12: 59,060,842 (GRCm39)		probably null	Het
Gm20521	T	A	14: 55,135,499 (GRCm39)	Y175N	probably damaging	Het
Gm3298	T	A	14: 5,018,778 (GRCm38)	C178S	probably benign	Het
Gpr45	A	G	1: 43,069,272 (GRCm39)		probably benign	Het
Gpr75	T	C	11: 30,842,190 (GRCm39)	I365T	possibly damaging	Het
Gsdmc2	T	C	15: 63,707,729 (GRCm39)	R22G	probably damaging	Het
Il23r	T	C	6: 67,443,256 (GRCm39)		probably benign	Het
Itgam	A	T	7: 127,684,114 (GRCm39)	T340S	probably benign	Het
Klk1b24	A	G	7: 43,841,294 (GRCm39)	D209G	possibly damaging	Het
Med13l	A	C	5: 118,886,898 (GRCm39)	T1600P	probably benign	Het
Muc16	G	T	9: 18,409,996 (GRCm39)	H137Q	probably damaging	Het
Nin	T	C	12: 70,090,805 (GRCm39)	E870G	probably damaging	Het
Or12k7	A	G	2: 36,958,497 (GRCm39)	Y60C	probably damaging	Het
Or5b120	A	G	19: 13,480,228 (GRCm39)	N174D	probably damaging	Het
Or6c215	A	T	10: 129,638,182 (GRCm39)	F71I	possibly damaging	Het
Pkhd1	T	C	1: 20,269,710 (GRCm39)	K3278R	possibly damaging	Het
Prlr	A	G	15: 10,328,664 (GRCm39)	N380D	probably benign	Het
Rpgr	A	C	X: 10,032,456 (GRCm39)	S582R	probably benign	Het
Rph3a	T	C	5: 121,084,411 (GRCm39)		probably null	Het
Setd5	A	G	6: 113,087,859 (GRCm39)	H140R	probably benign	Het
Stoml3	C	A	3: 53,405,540 (GRCm39)		probably benign	Het
Teddm1a	A	C	1: 153,767,545 (GRCm39)	D3A	probably benign	Het
Tmem207	A	G	16: 26,335,586 (GRCm39)		probably benign	Het
Triml1	T	A	8: 43,591,629 (GRCm39)	Q243L	possibly damaging	Het
Usp5	G	A	6: 124,799,672 (GRCm39)	T274M	probably damaging	Het
Vav2	A	G	2: 27,187,671 (GRCm39)		probably benign	Het
Wdr5b	A	G	16: 35,862,633 (GRCm39)	N251D	probably damaging	Het
Wnk2	C	A	13: 49,235,375 (GRCm39)		probably null	Het

Other mutations in Gpr37l1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00498:Gpr37l1	APN	1	135,089,440 (GRCm39)	splice site	probably benign
IGL01362:Gpr37l1	APN	1	135,089,216 (GRCm39)	missense	probably benign	0.00
IGL01678:Gpr37l1	APN	1	135,094,791 (GRCm39)	missense	probably damaging	1.00
ventura	UTSW	1	135,088,922 (GRCm39)	missense	probably damaging	1.00
R0045:Gpr37l1	UTSW	1	135,088,883 (GRCm39)	missense	probably damaging	1.00
R1199:Gpr37l1	UTSW	1	135,094,710 (GRCm39)	missense	probably damaging	1.00
R1730:Gpr37l1	UTSW	1	135,089,268 (GRCm39)	nonsense	probably null
R1733:Gpr37l1	UTSW	1	135,089,273 (GRCm39)	missense	possibly damaging	0.62
R1755:Gpr37l1	UTSW	1	135,094,639 (GRCm39)	missense	probably damaging	1.00
R3930:Gpr37l1	UTSW	1	135,089,100 (GRCm39)	missense	probably benign	0.01
R4091:Gpr37l1	UTSW	1	135,089,301 (GRCm39)	missense	probably benign	0.25
R4111:Gpr37l1	UTSW	1	135,095,008 (GRCm39)	missense	possibly damaging	0.69
R4288:Gpr37l1	UTSW	1	135,088,922 (GRCm39)	missense	probably damaging	1.00
R4739:Gpr37l1	UTSW	1	135,094,783 (GRCm39)	missense	probably damaging	0.99
R5114:Gpr37l1	UTSW	1	135,094,676 (GRCm39)	missense	probably damaging	1.00
R6765:Gpr37l1	UTSW	1	135,094,860 (GRCm39)	missense	probably damaging	1.00
R8441:Gpr37l1	UTSW	1	135,094,875 (GRCm39)	missense	probably damaging	0.97
R8734:Gpr37l1	UTSW	1	135,095,167 (GRCm39)	missense	probably benign
R9122:Gpr37l1	UTSW	1	135,095,209 (GRCm39)	missense	probably benign	0.00
R9715:Gpr37l1	UTSW	1	135,089,391 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16