Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02390:Or1o1'

294201

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or1o1

Ensembl Gene

ENSMUSG00000063188

Gene Name

olfactory receptor family 1 subfamily O member 1

Synonyms

MOR156-3, GA_x6K02T2PSCP-1867165-1868094, Olfr107

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.051) question?

Stock #

IGL02390

Quality Score

Status

Chromosome

Chromosomal Location

37716368-37717400 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 37716986 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Phenylalanine at position 182 (L182F)

Ref Sequence

ENSEMBL: ENSMUSP00000148879 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077008] [ENSMUST00000215894] [ENSMUST00000215947] [ENSMUST00000215974] [ENSMUST00000216844]

AlphaFold

Q7TRK4

Predicted Effect

probably benign
Transcript: ENSMUST00000077008
AA Change: L182F

PolyPhen 2 Score 0.042 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000076267
Gene: ENSMUSG00000063188
AA Change: L182F

Domain	Start	End	E-Value	Type
Pfam:7tm_4	28	305	1.3e-54	PFAM
Pfam:7TM_GPCR_Srsx	32	302	1.3e-5	PFAM
Pfam:7tm_1	38	287	3.7e-19	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000174238

Predicted Effect

probably benign
Transcript: ENSMUST00000215894
AA Change: L182F

PolyPhen 2 Score 0.042 (Sensitivity: 0.94; Specificity: 0.83)

Predicted Effect

probably benign
Transcript: ENSMUST00000215947
AA Change: L182F

PolyPhen 2 Score 0.042 (Sensitivity: 0.94; Specificity: 0.83)

Predicted Effect

probably benign
Transcript: ENSMUST00000215974
AA Change: L182F

PolyPhen 2 Score 0.042 (Sensitivity: 0.94; Specificity: 0.83)

Predicted Effect

probably benign
Transcript: ENSMUST00000216844
AA Change: L182F

PolyPhen 2 Score 0.042 (Sensitivity: 0.94; Specificity: 0.83)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca5	T	C	11: 110,187,377 (GRCm39)	K894R	probably benign	Het
Ampd1	C	T	3: 102,986,357 (GRCm39)	A12V	probably benign	Het
Ano4	T	A	10: 88,860,843 (GRCm39)	D345V	possibly damaging	Het
Arl6	A	G	16: 59,441,580 (GRCm39)		probably null	Het
Atp2a3	C	A	11: 72,866,165 (GRCm39)	H262N	probably benign	Het
Atrn	C	T	2: 130,862,897 (GRCm39)	P1326S	possibly damaging	Het
Btbd9	A	G	17: 30,743,788 (GRCm39)	V238A	probably benign	Het
Cdh16	T	C	8: 105,348,606 (GRCm39)	T141A	probably damaging	Het
Cetn4	T	C	3: 37,363,305 (GRCm39)	D102G	probably damaging	Het
Col5a3	T	A	9: 20,688,292 (GRCm39)	N1256I	unknown	Het
Cyfip2	A	G	11: 46,112,225 (GRCm39)	F993L	possibly damaging	Het
Dcaf6	T	A	1: 165,250,490 (GRCm39)	I125F	possibly damaging	Het
Dclk2	A	C	3: 86,731,990 (GRCm39)	S336A	probably damaging	Het
Dnah8	G	A	17: 31,049,819 (GRCm39)	V4327I	probably benign	Het
Ebna1bp2	T	C	4: 118,478,694 (GRCm39)	V59A	possibly damaging	Het
Efr3b	C	T	12: 4,033,391 (GRCm39)	V139I	probably benign	Het
F2	A	T	2: 91,463,332 (GRCm39)	V184D	possibly damaging	Het
Fbxo38	C	T	18: 62,666,660 (GRCm39)	R171H	probably damaging	Het
Fhod3	A	C	18: 25,199,332 (GRCm39)	S668R	probably benign	Het
Fkbp10	T	A	11: 100,306,843 (GRCm39)	F78L	probably damaging	Het
Garre1	T	C	7: 33,947,643 (GRCm39)	D455G	probably damaging	Het
Hyi	C	T	4: 118,219,810 (GRCm39)	R254C	probably benign	Het
Igfl3	A	T	7: 17,915,659 (GRCm39)		probably benign	Het
Lgals9	T	A	11: 78,854,361 (GRCm39)	I308F	probably damaging	Het
Lrrc8a	C	A	2: 30,146,713 (GRCm39)	P509Q	probably damaging	Het
Mapkap1	T	A	2: 34,322,101 (GRCm39)	N6K	probably damaging	Het
Mdh1b	T	A	1: 63,760,716 (GRCm39)	H115L	probably benign	Het
Med17	G	A	9: 15,188,963 (GRCm39)	R101*	probably null	Het
Mrpl15	T	C	1: 4,855,837 (GRCm39)	S22G	probably benign	Het
Nf1	T	C	11: 79,456,761 (GRCm39)	Y616H	possibly damaging	Het
Nf1	T	A	11: 79,302,502 (GRCm39)		probably benign	Het
Olig1	C	A	16: 91,067,041 (GRCm39)	Q93K	probably damaging	Het
Or13d1	T	A	4: 52,971,263 (GRCm39)	I214N	probably damaging	Het
Or4f59	A	T	2: 111,873,056 (GRCm39)	V107E	possibly damaging	Het
Otoa	C	A	7: 120,730,590 (GRCm39)	L597M	possibly damaging	Het
Parp16	C	T	9: 65,141,051 (GRCm39)	P207L	possibly damaging	Het
Pbrm1	T	A	14: 30,754,467 (GRCm39)	D162E	probably benign	Het
Pramel21	T	A	4: 143,341,895 (GRCm39)	M108K	probably benign	Het
Prdm10	A	G	9: 31,264,685 (GRCm39)	I658V	possibly damaging	Het
Psg21	A	T	7: 18,386,556 (GRCm39)	H143Q	probably benign	Het
Rfx4	C	T	10: 84,676,014 (GRCm39)	R28W	probably damaging	Het
Sart1	T	G	19: 5,430,489 (GRCm39)	M753L	possibly damaging	Het
Smcr8	T	A	11: 60,670,548 (GRCm39)	D565E	probably benign	Het
Smyd4	T	A	11: 75,278,332 (GRCm39)		probably null	Het
Sned1	T	C	1: 93,189,386 (GRCm39)	V274A	probably benign	Het
Tbc1d13	T	C	2: 30,027,399 (GRCm39)		probably benign	Het
Tox	A	T	4: 6,697,534 (GRCm39)	I423N	possibly damaging	Het
Tsc2	A	T	17: 24,819,427 (GRCm39)	V1232D	probably damaging	Het
Uckl1	C	T	2: 181,216,212 (GRCm39)	V178I	possibly damaging	Het
Usp13	T	A	3: 32,985,865 (GRCm39)	Y175*	probably null	Het
Vwde	A	G	6: 13,190,684 (GRCm39)	V469A	probably damaging	Het

Other mutations in Or1o1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01323:Or1o1	APN	17	37,717,031 (GRCm39)	missense	probably benign	0.00
IGL01614:Or1o1	APN	17	37,716,529 (GRCm39)	missense	probably benign	0.00
R1051:Or1o1	UTSW	17	37,717,341 (GRCm39)	missense	possibly damaging	0.74
R4767:Or1o1	UTSW	17	37,717,091 (GRCm39)	nonsense	probably null
R4849:Or1o1	UTSW	17	37,716,589 (GRCm39)	missense	probably benign	0.16
R6182:Or1o1	UTSW	17	37,716,883 (GRCm39)	missense	possibly damaging	0.65
R6550:Or1o1	UTSW	17	37,716,796 (GRCm39)	missense	probably benign	0.30
R6551:Or1o1	UTSW	17	37,716,796 (GRCm39)	missense	probably benign	0.30
R6552:Or1o1	UTSW	17	37,716,796 (GRCm39)	missense	probably benign	0.30
R6555:Or1o1	UTSW	17	37,716,796 (GRCm39)	missense	probably benign	0.30
R6584:Or1o1	UTSW	17	37,716,796 (GRCm39)	missense	probably benign	0.30
R6586:Or1o1	UTSW	17	37,716,796 (GRCm39)	missense	probably benign	0.30
R6588:Or1o1	UTSW	17	37,716,796 (GRCm39)	missense	probably benign	0.30
R6688:Or1o1	UTSW	17	37,716,796 (GRCm39)	missense	probably benign	0.30
R6758:Or1o1	UTSW	17	37,716,586 (GRCm39)	missense	probably damaging	0.97
R7024:Or1o1	UTSW	17	37,717,095 (GRCm39)	missense	probably benign	0.04
R7083:Or1o1	UTSW	17	37,717,063 (GRCm39)	missense	probably benign	0.00
R8350:Or1o1	UTSW	17	37,717,260 (GRCm39)	missense	probably benign	0.00

Posted On

2015-04-16