Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02507:Or5d16'

296400

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or5d16

Ensembl Gene

ENSMUSG00000075145

Gene Name

olfactory receptor family 5 subfamily D member 16

Synonyms

Olfr1155, GA_x6K02T2Q125-49426894-49425950, MOR174-10

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.100) question?

Stock #

IGL02507

Quality Score

Status

Chromosome

Chromosomal Location

87773026-87773970 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to A at 87773262 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Stop codon at position 237 (R237*)

Ref Sequence

ENSEMBL: ENSMUSP00000149428 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099843] [ENSMUST00000214641] [ENSMUST00000215903] [ENSMUST00000216191] [ENSMUST00000216726]

AlphaFold

Q8VFR3

Predicted Effect

probably null
Transcript: ENSMUST00000099843
AA Change: R237*

SMART Domains

Protein: ENSMUSP00000097431
Gene: ENSMUSG00000075145
AA Change: R237*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	33	310	2.7e-44	PFAM
Pfam:7tm_1	43	292	5.3e-16	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000214641
AA Change: R237*

Predicted Effect

probably null
Transcript: ENSMUST00000215903
AA Change: R237*

Predicted Effect

probably benign
Transcript: ENSMUST00000216191

Predicted Effect

probably benign
Transcript: ENSMUST00000216726

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	A	G	11: 9,349,388 (GRCm39)	Y3654C	probably damaging	Het
Aldh1l2	A	C	10: 83,328,448 (GRCm39)	Y756*	probably null	Het
Arhgef12	T	C	9: 42,903,859 (GRCm39)	E733G	probably damaging	Het
Art5	A	T	7: 101,748,699 (GRCm39)	M1K	probably null	Het
Atp1a2	A	T	1: 172,113,338 (GRCm39)	D448E	probably damaging	Het
Atp6v1b1	C	T	6: 83,733,837 (GRCm39)	T356I	possibly damaging	Het
Celsr1	A	G	15: 85,784,889 (GRCm39)		probably benign	Het
Cep89	A	G	7: 35,134,990 (GRCm39)	Y686C	probably damaging	Het
Cgrrf1	T	A	14: 47,090,901 (GRCm39)	Y212*	probably null	Het
Chrnb1	T	C	11: 69,675,916 (GRCm39)	Y442C	probably damaging	Het
Clcn1	T	C	6: 42,284,007 (GRCm39)		probably benign	Het
Clcn7	G	A	17: 25,363,443 (GRCm39)	V40M	probably damaging	Het
Cntn1	A	G	15: 92,148,860 (GRCm39)	Y369C	possibly damaging	Het
Csmd1	T	C	8: 17,584,992 (GRCm39)		probably benign	Het
Dpy19l2	A	T	9: 24,542,563 (GRCm39)	C446S	probably benign	Het
Edem3	G	A	1: 151,687,407 (GRCm39)	E782K	probably benign	Het
Efcab15	T	A	11: 103,090,275 (GRCm39)	Q287L	probably damaging	Het
Ephb3	T	A	16: 21,039,389 (GRCm39)		probably benign	Het
Fndc4	T	C	5: 31,452,090 (GRCm39)	D109G	probably damaging	Het
Fras1	T	C	5: 96,805,267 (GRCm39)	V1303A	possibly damaging	Het
Gcn1	T	C	5: 115,723,940 (GRCm39)	L532P	probably benign	Het
Gm5150	A	G	3: 16,017,485 (GRCm39)	L262P	probably damaging	Het
Hbb-bs	T	C	7: 103,477,091 (GRCm39)		probably benign	Het
Krt74	A	G	15: 101,669,059 (GRCm39)		noncoding transcript	Het
Myo1a	T	C	10: 127,548,478 (GRCm39)	V375A	probably damaging	Het
Nup160	A	T	2: 90,560,079 (GRCm39)	Q1268L	probably benign	Het
Or4k42	G	A	2: 111,319,768 (GRCm39)	T245M	possibly damaging	Het
Or51ag1	G	T	7: 103,155,925 (GRCm39)	S76*	probably null	Het
Or9s27	T	C	1: 92,516,648 (GRCm39)	S199P	possibly damaging	Het
Pan3	T	C	5: 147,463,406 (GRCm39)	S497P	probably damaging	Het
Pex5	T	C	6: 124,390,264 (GRCm39)	T138A	probably benign	Het
Pik3ap1	A	G	19: 41,270,451 (GRCm39)		probably benign	Het
Ptchd4	A	T	17: 42,627,764 (GRCm39)	H75L	possibly damaging	Het
Rag2	A	T	2: 101,461,055 (GRCm39)	H455L	probably damaging	Het
Rergl	T	A	6: 139,470,351 (GRCm39)	E159V	probably damaging	Het
Rrn3	A	G	16: 13,606,721 (GRCm39)	N109S	probably benign	Het
Scn1a	A	T	2: 66,108,157 (GRCm39)	V1523D	probably damaging	Het
Sec23a	A	G	12: 59,053,884 (GRCm39)	V38A	probably benign	Het
Slc15a2	G	A	16: 36,602,021 (GRCm39)	T92M	possibly damaging	Het
Slc2a2	A	G	3: 28,781,260 (GRCm39)	T433A	probably benign	Het
Sptan1	A	G	2: 29,906,067 (GRCm39)	D1671G	probably damaging	Het
Stab1	A	G	14: 30,861,167 (GRCm39)		probably benign	Het
Stau2	A	T	1: 16,556,293 (GRCm39)	I22N	possibly damaging	Het
Strn3	A	T	12: 51,708,410 (GRCm39)	Y123*	probably null	Het
Tmem205	A	G	9: 21,837,607 (GRCm39)	V13A	possibly damaging	Het
Trub1	G	A	19: 57,472,009 (GRCm39)		probably benign	Het
Ttn	A	G	2: 76,568,699 (GRCm39)	V27398A	possibly damaging	Het
Vill	A	G	9: 118,899,845 (GRCm39)	E343G	possibly damaging	Het
Zgpat	T	C	2: 181,008,029 (GRCm39)	F189L	probably damaging	Het

Other mutations in Or5d16

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03245:Or5d16	APN	2	87,773,086 (GRCm39)	missense	possibly damaging	0.75
B5639:Or5d16	UTSW	2	87,773,942 (GRCm39)	missense	probably benign	0.03
PIT4531001:Or5d16	UTSW	2	87,773,571 (GRCm39)	missense	probably damaging	1.00
R0212:Or5d16	UTSW	2	87,773,435 (GRCm39)	missense	probably damaging	1.00
R0393:Or5d16	UTSW	2	87,773,909 (GRCm39)	missense	possibly damaging	0.62
R1178:Or5d16	UTSW	2	87,773,490 (GRCm39)	missense	probably benign	0.02
R1180:Or5d16	UTSW	2	87,773,490 (GRCm39)	missense	probably benign	0.02
R1181:Or5d16	UTSW	2	87,773,490 (GRCm39)	missense	probably benign	0.02
R1266:Or5d16	UTSW	2	87,773,877 (GRCm39)	missense	probably benign	0.01
R1847:Or5d16	UTSW	2	87,773,065 (GRCm39)	splice site	probably null
R1998:Or5d16	UTSW	2	87,773,490 (GRCm39)	missense	probably benign	0.02
R2000:Or5d16	UTSW	2	87,773,490 (GRCm39)	missense	probably benign	0.02
R4119:Or5d16	UTSW	2	87,773,787 (GRCm39)	missense	probably damaging	1.00
R4213:Or5d16	UTSW	2	87,773,465 (GRCm39)	missense	probably benign	0.00
R5157:Or5d16	UTSW	2	87,773,232 (GRCm39)	missense	probably benign
R5688:Or5d16	UTSW	2	87,773,552 (GRCm39)	missense	probably benign	0.02
R5731:Or5d16	UTSW	2	87,773,771 (GRCm39)	missense	possibly damaging	0.89
R6064:Or5d16	UTSW	2	87,773,828 (GRCm39)	missense	probably benign	0.00
R6372:Or5d16	UTSW	2	87,773,319 (GRCm39)	missense	probably benign	0.00
R6505:Or5d16	UTSW	2	87,773,518 (GRCm39)	nonsense	probably null
R6555:Or5d16	UTSW	2	87,773,632 (GRCm39)	missense	probably damaging	1.00
R6909:Or5d16	UTSW	2	87,773,034 (GRCm39)	missense	probably benign	0.27
R7257:Or5d16	UTSW	2	87,773,915 (GRCm39)	missense	probably damaging	1.00
R8037:Or5d16	UTSW	2	87,773,319 (GRCm39)	missense	probably benign	0.00
R8367:Or5d16	UTSW	2	87,773,441 (GRCm39)	missense	possibly damaging	0.75
R9301:Or5d16	UTSW	2	87,773,297 (GRCm39)	missense	probably benign	0.00
Z1088:Or5d16	UTSW	2	87,773,792 (GRCm39)	missense	probably damaging	1.00
Z1176:Or5d16	UTSW	2	87,773,811 (GRCm39)	missense	probably damaging	1.00
Z1176:Or5d16	UTSW	2	87,773,553 (GRCm39)	missense	possibly damaging	0.57

Posted On

2015-04-16