Incidental Mutation 'IGL02536:Pvr'
ID 297488
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Pvr
Ensembl Gene ENSMUSG00000040511
Gene Name poliovirus receptor
Synonyms necl-5, CD155, 3830421F03Rik, Tage4, mE4, Taa1, D7Ertd458e
Accession Numbers
Essential gene? Probably non essential (E-score: 0.120) question?
Stock # IGL02536
Quality Score
Status
Chromosome 7
Chromosomal Location 19637503-19655068 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 19652717 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Threonine at position 66 (M66T)
Ref Sequence ENSEMBL: ENSMUSP00000039205 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043517]
AlphaFold Q8K094
Predicted Effect probably benign
Transcript: ENSMUST00000043517
AA Change: M66T

PolyPhen 2 Score 0.174 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000039205
Gene: ENSMUSG00000040511
AA Change: M66T

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
IG 35 142 1.58e-10 SMART
Pfam:C2-set_2 145 231 2e-18 PFAM
Pfam:C1-set 160 233 1.3e-5 PFAM
IG_like 254 334 6.75e1 SMART
transmembrane domain 348 370 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159261
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160572
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162649
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208861
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for one null allele have a reduced antibody response to oral immunization. Mice homozygous for a different null allele exhibit reduced susceptibility to chemically induced colon cancer. [provided by MGI curators]
Allele List at MGI

All alleles(6) : Targeted, knock-out(2) Targeted, other(2) Gene trapped(2)
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930449A18Rik T A 3: 59,685,665 (GRCm39) noncoding transcript Het
Abca8b C T 11: 109,872,574 (GRCm39) R9H probably benign Het
Adamts8 T A 9: 30,873,368 (GRCm39) S858T probably benign Het
Alg1 C T 16: 5,057,023 (GRCm39) Q245* probably null Het
Ankmy1 T C 1: 92,813,910 (GRCm39) Y423C probably damaging Het
Anp32a A T 9: 62,279,110 (GRCm39) T55S probably damaging Het
Arhgef9 A C X: 94,102,443 (GRCm39) V406G probably damaging Het
Bdkrb1 T C 12: 105,571,259 (GRCm39) F275S possibly damaging Het
Card9 C T 2: 26,248,844 (GRCm39) V102I possibly damaging Het
Ccdc81 A T 7: 89,526,788 (GRCm39) probably benign Het
Cd101 T A 3: 100,910,913 (GRCm39) D915V probably damaging Het
Cdk10 A G 8: 123,953,754 (GRCm39) D77G possibly damaging Het
Ctnnd1 T C 2: 84,435,540 (GRCm39) T827A probably benign Het
Dspp A C 5: 104,323,531 (GRCm39) T225P probably damaging Het
Evpl T C 11: 116,112,035 (GRCm39) E1885G probably damaging Het
Fstl4 C T 11: 53,024,851 (GRCm39) probably benign Het
Gm5930 T A 14: 44,575,015 (GRCm39) N57I probably damaging Het
Gnl2 C T 4: 124,946,401 (GRCm39) Q541* probably null Het
Igkv3-1 T C 6: 70,681,035 (GRCm39) V78A probably benign Het
Inpp5a T C 7: 139,147,338 (GRCm39) I321T probably benign Het
Kif20b T A 19: 34,951,959 (GRCm39) S1746T probably benign Het
Lrrc8c T C 5: 105,755,038 (GRCm39) I271T probably benign Het
Mrps10 T C 17: 47,685,928 (GRCm39) Y152H probably damaging Het
Myl9 C T 2: 156,620,469 (GRCm39) S2L probably damaging Het
Myof A T 19: 37,938,103 (GRCm39) H870Q probably damaging Het
Nfatc4 A T 14: 56,067,367 (GRCm39) I456F probably damaging Het
Notch2 A G 3: 98,009,723 (GRCm39) H550R probably benign Het
Or13f5 T A 4: 52,825,817 (GRCm39) V140D possibly damaging Het
Or14j2 T A 17: 37,885,817 (GRCm39) I166F probably damaging Het
Or51v8 T A 7: 103,320,164 (GRCm39) I25F possibly damaging Het
Or8b47 T C 9: 38,435,460 (GRCm39) L144P probably damaging Het
P2rx1 A T 11: 72,903,300 (GRCm39) I230F probably damaging Het
Pcnt A G 10: 76,216,063 (GRCm39) V2275A possibly damaging Het
Pip5k1a G A 3: 94,971,707 (GRCm39) T465I probably benign Het
Pnkd G A 1: 74,391,059 (GRCm39) R415H probably damaging Het
Prdx4 T A X: 154,115,443 (GRCm39) I132F probably damaging Het
Rnf216 A G 5: 143,065,995 (GRCm39) I531T probably benign Het
Rps6ka4 A T 19: 6,809,439 (GRCm39) F405Y probably damaging Het
Serpinb2 A G 1: 107,452,679 (GRCm39) probably benign Het
Sfxn1 A G 13: 54,239,513 (GRCm39) K12R probably benign Het
Slc17a7 A G 7: 44,820,370 (GRCm39) E275G probably damaging Het
Tnpo2 A T 8: 85,771,696 (GRCm39) I245F probably benign Het
Ush2a A T 1: 188,689,463 (GRCm39) probably null Het
Yju2b A T 8: 84,987,245 (GRCm39) Y109* probably null Het
Zcchc4 C T 5: 52,965,658 (GRCm39) R321W probably damaging Het
Other mutations in Pvr
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00742:Pvr APN 7 19,648,784 (GRCm39) missense probably damaging 1.00
IGL01700:Pvr APN 7 19,643,157 (GRCm39) missense probably benign 0.11
F2404:Pvr UTSW 7 19,639,102 (GRCm39) missense probably benign 0.06
R1016:Pvr UTSW 7 19,643,142 (GRCm39) missense probably benign
R1470:Pvr UTSW 7 19,652,549 (GRCm39) missense possibly damaging 0.51
R1470:Pvr UTSW 7 19,652,549 (GRCm39) missense possibly damaging 0.51
R1525:Pvr UTSW 7 19,644,551 (GRCm39) nonsense probably null
R2138:Pvr UTSW 7 19,650,927 (GRCm39) missense probably damaging 1.00
R3912:Pvr UTSW 7 19,643,217 (GRCm39) missense probably benign 0.01
R6667:Pvr UTSW 7 19,639,727 (GRCm39) missense probably benign 0.07
R6724:Pvr UTSW 7 19,652,604 (GRCm39) missense possibly damaging 0.95
R6855:Pvr UTSW 7 19,643,139 (GRCm39) missense possibly damaging 0.92
R6866:Pvr UTSW 7 19,652,555 (GRCm39) missense probably benign 0.01
R7030:Pvr UTSW 7 19,639,105 (GRCm39) missense possibly damaging 0.84
R7158:Pvr UTSW 7 19,652,562 (GRCm39) nonsense probably null
R7352:Pvr UTSW 7 19,644,541 (GRCm39) missense possibly damaging 0.81
R8853:Pvr UTSW 7 19,650,897 (GRCm39) missense possibly damaging 0.89
R9084:Pvr UTSW 7 19,650,937 (GRCm39) missense possibly damaging 0.73
R9720:Pvr UTSW 7 19,643,121 (GRCm39) nonsense probably null
X0025:Pvr UTSW 7 19,644,577 (GRCm39) missense probably benign 0.38
Posted On 2015-04-16