Incidental Mutation 'IGL02666:Gbp9'
| ID |
302756 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Gbp9
|
| Ensembl Gene |
ENSMUSG00000029298 |
| Gene Name |
guanylate-binding protein 9 |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.055)
|
| Stock # |
IGL02666
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
5 |
| Chromosomal Location |
105224332-105258255 bp(-) (GRCm39) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
T to C
at 105242141 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000098521
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000031235]
[ENSMUST00000031238]
[ENSMUST00000100961]
|
| AlphaFold |
Q8BTS3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000031235
|
| SMART Domains |
Protein: ENSMUSP00000031235
Gene: ENSMUSG00000034438
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:GBP
|
16 |
213 |
5.4e-91 |
PFAM |
|
Pfam:GBP_C
|
206 |
493 |
1e-115 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000031238
|
| SMART Domains |
Protein: ENSMUSP00000031238
Gene: ENSMUSG00000029298
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:GBP
|
16 |
279 |
1.2e-117 |
PFAM |
|
Pfam:GBP_C
|
281 |
575 |
4.5e-115 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000100961
|
| SMART Domains |
Protein: ENSMUSP00000098521
Gene: ENSMUSG00000029298
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:GBP
|
16 |
279 |
3.8e-124 |
PFAM |
|
Pfam:GBP_C
|
281 |
575 |
4.5e-115 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000196820
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 49 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 9230109A22Rik |
T |
C |
15: 25,138,944 (GRCm39) |
|
noncoding transcript |
Het |
| Abca15 |
G |
A |
7: 119,934,431 (GRCm39) |
V136M |
probably damaging |
Het |
| Abhd3 |
A |
G |
18: 10,645,148 (GRCm39) |
I382T |
probably benign |
Het |
| Cux1 |
C |
A |
5: 136,304,169 (GRCm39) |
E1336* |
probably null |
Het |
| Cyb5r3 |
T |
C |
15: 83,044,554 (GRCm39) |
I155V |
probably damaging |
Het |
| Ddx24 |
T |
C |
12: 103,390,314 (GRCm39) |
T226A |
possibly damaging |
Het |
| Dld |
T |
C |
12: 31,382,408 (GRCm39) |
N465S |
probably null |
Het |
| Dnmbp |
A |
G |
19: 43,842,566 (GRCm39) |
|
probably benign |
Het |
| Dock9 |
T |
C |
14: 121,818,111 (GRCm39) |
H1580R |
probably benign |
Het |
| Drd3 |
C |
A |
16: 43,637,319 (GRCm39) |
|
probably benign |
Het |
| Gabrb2 |
G |
T |
11: 42,420,322 (GRCm39) |
|
probably null |
Het |
| Inhba |
A |
T |
13: 16,201,664 (GRCm39) |
I409F |
possibly damaging |
Het |
| Iqgap2 |
T |
C |
13: 95,764,564 (GRCm39) |
N1560S |
probably damaging |
Het |
| Itsn1 |
A |
G |
16: 91,617,606 (GRCm39) |
|
probably benign |
Het |
| Kat6b |
T |
C |
14: 21,678,938 (GRCm39) |
F434L |
probably damaging |
Het |
| Klra1 |
A |
G |
6: 130,341,278 (GRCm39) |
C232R |
probably damaging |
Het |
| Krt18 |
T |
A |
15: 101,938,302 (GRCm39) |
I175N |
probably damaging |
Het |
| Lck |
A |
G |
4: 129,450,212 (GRCm39) |
V178A |
probably damaging |
Het |
| Mroh4 |
C |
A |
15: 74,481,624 (GRCm39) |
G737V |
probably benign |
Het |
| Mug2 |
A |
C |
6: 122,058,285 (GRCm39) |
L1282F |
probably damaging |
Het |
| Myo9a |
A |
G |
9: 59,832,187 (GRCm39) |
N2572S |
probably benign |
Het |
| Nup88 |
G |
T |
11: 70,834,695 (GRCm39) |
|
probably benign |
Het |
| Nxph3 |
G |
T |
11: 95,401,834 (GRCm39) |
H193Q |
possibly damaging |
Het |
| Or5b97 |
G |
T |
19: 12,878,221 (GRCm39) |
H308N |
probably benign |
Het |
| Orm2 |
A |
G |
4: 63,283,970 (GRCm39) |
T198A |
possibly damaging |
Het |
| Pom121 |
T |
C |
5: 135,415,686 (GRCm39) |
I397V |
unknown |
Het |
| Prex1 |
C |
A |
2: 166,414,909 (GRCm39) |
E1313D |
probably benign |
Het |
| Prkg2 |
T |
A |
5: 99,145,378 (GRCm39) |
|
probably benign |
Het |
| Prl2a1 |
A |
T |
13: 27,990,310 (GRCm39) |
K86N |
possibly damaging |
Het |
| Ptpro |
G |
A |
6: 137,355,057 (GRCm39) |
S188N |
probably damaging |
Het |
| Ptprz1 |
A |
T |
6: 23,001,209 (GRCm39) |
I1100F |
probably benign |
Het |
| Ryr1 |
C |
A |
7: 28,719,188 (GRCm39) |
M4406I |
unknown |
Het |
| Sdf4 |
T |
A |
4: 156,093,281 (GRCm39) |
Y204* |
probably null |
Het |
| Serinc1 |
A |
T |
10: 57,400,089 (GRCm39) |
|
probably null |
Het |
| Slc39a5 |
C |
T |
10: 128,234,324 (GRCm39) |
R193H |
probably damaging |
Het |
| Smad9 |
A |
G |
3: 54,689,888 (GRCm39) |
K36R |
probably damaging |
Het |
| Spam1 |
T |
A |
6: 24,796,123 (GRCm39) |
L25I |
possibly damaging |
Het |
| Stab2 |
A |
T |
10: 86,686,766 (GRCm39) |
S809R |
possibly damaging |
Het |
| Szt2 |
G |
A |
4: 118,231,252 (GRCm39) |
R35C |
probably damaging |
Het |
| Tcaf2 |
C |
A |
6: 42,606,058 (GRCm39) |
|
probably benign |
Het |
| Tfap2d |
A |
C |
1: 19,174,979 (GRCm39) |
D144A |
probably benign |
Het |
| Tmprss11d |
A |
T |
5: 86,479,052 (GRCm39) |
V117D |
probably damaging |
Het |
| Tnxb |
A |
G |
17: 34,903,913 (GRCm39) |
D1141G |
probably benign |
Het |
| Traf6 |
A |
T |
2: 101,527,512 (GRCm39) |
T421S |
possibly damaging |
Het |
| Txndc16 |
G |
A |
14: 45,448,607 (GRCm39) |
|
probably benign |
Het |
| Utp25 |
G |
A |
1: 192,789,904 (GRCm39) |
Q752* |
probably null |
Het |
| Vmn1r73 |
C |
A |
7: 11,490,865 (GRCm39) |
P228T |
probably damaging |
Het |
| Vmn2r4 |
A |
G |
3: 64,296,433 (GRCm39) |
I784T |
probably benign |
Het |
| Zfp420 |
A |
G |
7: 29,573,795 (GRCm39) |
D5G |
probably benign |
Het |
|
| Other mutations in Gbp9 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00094:Gbp9
|
APN |
5 |
105,229,130 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL00419:Gbp9
|
APN |
5 |
105,241,943 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL00425:Gbp9
|
APN |
5 |
105,253,620 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL00597:Gbp9
|
APN |
5 |
105,242,364 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01362:Gbp9
|
APN |
5 |
105,228,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01679:Gbp9
|
APN |
5 |
105,233,038 (GRCm39) |
splice site |
probably null |
|
|
IGL01803:Gbp9
|
APN |
5 |
105,232,884 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01803:Gbp9
|
APN |
5 |
105,242,039 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02054:Gbp9
|
APN |
5 |
105,230,673 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL02474:Gbp9
|
APN |
5 |
105,242,433 (GRCm39) |
splice site |
probably benign |
|
|
IGL02633:Gbp9
|
APN |
5 |
105,231,431 (GRCm39) |
splice site |
probably benign |
|
|
IGL02689:Gbp9
|
APN |
5 |
105,253,662 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL02812:Gbp9
|
APN |
5 |
105,231,624 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03132:Gbp9
|
APN |
5 |
105,232,819 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
IGL03274:Gbp9
|
APN |
5 |
105,230,652 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R0410:Gbp9
|
UTSW |
5 |
105,232,939 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1018:Gbp9
|
UTSW |
5 |
105,228,126 (GRCm39) |
missense |
probably benign |
0.15 |
|
R1479:Gbp9
|
UTSW |
5 |
105,241,930 (GRCm39) |
splice site |
probably benign |
|
|
R1655:Gbp9
|
UTSW |
5 |
105,229,558 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R1658:Gbp9
|
UTSW |
5 |
105,242,334 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1757:Gbp9
|
UTSW |
5 |
105,242,319 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1950:Gbp9
|
UTSW |
5 |
105,229,112 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1986:Gbp9
|
UTSW |
5 |
105,253,652 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1986:Gbp9
|
UTSW |
5 |
105,253,590 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2124:Gbp9
|
UTSW |
5 |
105,242,409 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2302:Gbp9
|
UTSW |
5 |
105,241,958 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R2378:Gbp9
|
UTSW |
5 |
105,228,042 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2997:Gbp9
|
UTSW |
5 |
105,230,635 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3745:Gbp9
|
UTSW |
5 |
105,253,724 (GRCm39) |
start gained |
probably benign |
|
|
R4182:Gbp9
|
UTSW |
5 |
105,231,461 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4485:Gbp9
|
UTSW |
5 |
105,231,674 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4718:Gbp9
|
UTSW |
5 |
105,231,624 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5063:Gbp9
|
UTSW |
5 |
105,233,028 (GRCm39) |
missense |
probably benign |
|
|
R5099:Gbp9
|
UTSW |
5 |
105,242,379 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5104:Gbp9
|
UTSW |
5 |
105,228,007 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5199:Gbp9
|
UTSW |
5 |
105,231,678 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5712:Gbp9
|
UTSW |
5 |
105,242,421 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R5751:Gbp9
|
UTSW |
5 |
105,229,124 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5895:Gbp9
|
UTSW |
5 |
105,230,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6360:Gbp9
|
UTSW |
5 |
105,231,596 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6646:Gbp9
|
UTSW |
5 |
105,230,769 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7559:Gbp9
|
UTSW |
5 |
105,232,975 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7819:Gbp9
|
UTSW |
5 |
105,251,745 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R8042:Gbp9
|
UTSW |
5 |
105,242,108 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8288:Gbp9
|
UTSW |
5 |
105,253,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8303:Gbp9
|
UTSW |
5 |
105,229,171 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8354:Gbp9
|
UTSW |
5 |
105,242,027 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8395:Gbp9
|
UTSW |
5 |
105,228,069 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8397:Gbp9
|
UTSW |
5 |
105,231,464 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8751:Gbp9
|
UTSW |
5 |
105,229,117 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R8808:Gbp9
|
UTSW |
5 |
105,232,875 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9105:Gbp9
|
UTSW |
5 |
105,241,942 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9116:Gbp9
|
UTSW |
5 |
105,231,695 (GRCm39) |
missense |
|
|
|
R9354:Gbp9
|
UTSW |
5 |
105,232,825 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R9513:Gbp9
|
UTSW |
5 |
105,229,091 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9709:Gbp9
|
UTSW |
5 |
105,231,542 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9717:Gbp9
|
UTSW |
5 |
105,253,587 (GRCm39) |
nonsense |
probably null |
|
|
Z1088:Gbp9
|
UTSW |
5 |
105,241,991 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2015-04-16 |
Incidental Mutation