Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02698:Dcp1a'

304053

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Dcp1a

Ensembl Gene

ENSMUSG00000021962

Gene Name

decapping mRNA 1A

Synonyms

SMIF, Mitc1, 1110066A22Rik, D14Ertd817e, 4930568L04Rik

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.262) question?

Stock #

IGL02698

Quality Score

Status

Chromosome

Chromosomal Location

30201613-30249013 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to T at 30227499 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000153074 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000022535] [ENSMUST00000225196] [ENSMUST00000225286]

AlphaFold

Q91YD3

Predicted Effect

probably benign
Transcript: ENSMUST00000022535

SMART Domains

Protein: ENSMUSP00000022535
Gene: ENSMUSG00000021962

Domain	Start	End	E-Value	Type
Pfam:DCP1	28	144	1.8e-44	PFAM
low complexity region	327	343	N/A	INTRINSIC
low complexity region	457	472	N/A	INTRINSIC
Pfam:mRNA_decap_C	559	601	6.3e-22	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000223658

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000224453

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000224692

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000224810

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000225124

Predicted Effect

probably benign
Transcript: ENSMUST00000225196

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000225243

Predicted Effect

probably benign
Transcript: ENSMUST00000225286

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000225521

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000225806

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000225923

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arpp21	T	A	9: 112,014,812 (GRCm39)		probably benign	Het
Car8	A	T	4: 8,185,598 (GRCm39)	I186N	probably benign	Het
Ccdc174	G	A	6: 91,867,834 (GRCm39)	S183N	probably benign	Het
Ccdc66	T	A	14: 27,212,749 (GRCm39)	K525*	probably null	Het
Cebpz	A	G	17: 79,243,003 (GRCm39)	V217A	probably benign	Het
Cfap36	C	A	11: 29,197,014 (GRCm39)		probably null	Het
Cpne4	T	C	9: 104,909,984 (GRCm39)	V527A	probably damaging	Het
Crh	T	G	3: 19,748,354 (GRCm39)	D96A	possibly damaging	Het
Csgalnact1	C	A	8: 68,854,144 (GRCm39)	G219V	probably damaging	Het
Ddhd1	A	T	14: 45,842,663 (GRCm39)		probably benign	Het
Dis3l2	C	T	1: 86,976,551 (GRCm39)		probably benign	Het
Dop1a	T	C	9: 86,406,412 (GRCm39)		probably benign	Het
Etv3	A	G	3: 87,443,885 (GRCm39)	T490A	possibly damaging	Het
Fastkd2	A	G	1: 63,787,158 (GRCm39)	T531A	probably benign	Het
Fat1	C	T	8: 45,476,201 (GRCm39)	A1749V	probably benign	Het
Fgfr1	T	A	8: 26,063,624 (GRCm39)	L761*	probably null	Het
Gcc2	A	G	10: 58,107,112 (GRCm39)	K683E	possibly damaging	Het
Gm5117	C	T	8: 32,229,767 (GRCm39)		noncoding transcript	Het
Hif1a	T	C	12: 73,977,545 (GRCm39)		probably null	Het
Inha	A	G	1: 75,486,527 (GRCm39)	E274G	probably damaging	Het
Itih2	G	T	2: 10,135,312 (GRCm39)	P26H	probably damaging	Het
Kif23	G	A	9: 61,832,283 (GRCm39)	T620I	possibly damaging	Het
Klhl30	T	C	1: 91,281,429 (GRCm39)	F10S	probably damaging	Het
Kmt2b	T	C	7: 30,278,118 (GRCm39)		probably benign	Het
Lmf2	A	C	15: 89,238,357 (GRCm39)	L174R	probably damaging	Het
Med13l	T	C	5: 118,900,894 (GRCm39)	L2216P	probably damaging	Het
Mmp1b	T	A	9: 7,384,877 (GRCm39)	L257F	probably damaging	Het
Net1	A	G	13: 3,937,569 (GRCm39)		probably null	Het
Nfasc	A	G	1: 132,562,475 (GRCm39)	V100A	probably benign	Het
Nr4a2	A	G	2: 56,998,172 (GRCm39)	F535S	probably damaging	Het
Ntn4	G	T	10: 93,480,521 (GRCm39)	A45S	probably benign	Het
Or2y1c	T	A	11: 49,361,690 (GRCm39)	F237L	probably benign	Het
Or4a27	T	A	2: 88,559,815 (GRCm39)	I43F	probably damaging	Het
Or52a20	T	C	7: 103,366,485 (GRCm39)	V228A	probably damaging	Het
Or5w17	T	A	2: 87,584,188 (GRCm39)	K50*	probably null	Het
Or8c9	A	G	9: 38,241,506 (GRCm39)	T208A	probably benign	Het
Pappa	A	T	4: 65,099,257 (GRCm39)	E592V	probably damaging	Het
Pate10	T	C	9: 35,652,416 (GRCm39)		probably benign	Het
Pi4ka	A	T	16: 17,109,032 (GRCm39)	I1630N	probably damaging	Het
Ptprb	A	G	10: 116,199,185 (GRCm39)	D1997G	probably benign	Het
Rc3h2	A	T	2: 37,295,312 (GRCm39)	S235T	probably damaging	Het
S1pr1	T	A	3: 115,505,746 (GRCm39)	K283*	probably null	Het
Scn5a	T	A	9: 119,350,163 (GRCm39)	T904S	probably damaging	Het
Sema6d	T	C	2: 124,495,643 (GRCm39)	L30P	possibly damaging	Het
Slc26a7	A	C	4: 14,593,867 (GRCm39)	S83A	possibly damaging	Het
Slco1a6	C	A	6: 142,048,737 (GRCm39)	G348*	probably null	Het
Srgap3	C	T	6: 112,723,889 (GRCm39)	V524I	probably damaging	Het
Stxbp3-ps	A	T	19: 9,535,688 (GRCm39)		noncoding transcript	Het
Sv2b	C	T	7: 74,790,726 (GRCm39)		probably null	Het
Sympk	T	C	7: 18,779,559 (GRCm39)	I663T	probably benign	Het
Ttn	C	A	2: 76,775,115 (GRCm39)	V1976L	probably damaging	Het
Uqcrc1	T	C	9: 108,777,011 (GRCm39)		probably null	Het
Vmn2r111	T	C	17: 22,790,226 (GRCm39)	Y260C	probably damaging	Het

Other mutations in Dcp1a

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01653:Dcp1a	APN	14	30,227,528 (GRCm39)	missense	possibly damaging	0.52
IGL02799:Dcp1a	UTSW	14	30,241,636 (GRCm39)	critical splice donor site	probably null
R0240:Dcp1a	UTSW	14	30,206,551 (GRCm39)	splice site	probably benign
R0387:Dcp1a	UTSW	14	30,241,636 (GRCm39)	critical splice donor site	probably null
R0646:Dcp1a	UTSW	14	30,224,842 (GRCm39)	missense	probably damaging	1.00
R1781:Dcp1a	UTSW	14	30,235,032 (GRCm39)	missense	probably benign	0.37
R1843:Dcp1a	UTSW	14	30,240,940 (GRCm39)	missense	probably damaging	0.99
R2111:Dcp1a	UTSW	14	30,241,327 (GRCm39)	missense	probably benign	0.00
R3176:Dcp1a	UTSW	14	30,227,499 (GRCm39)	splice site	probably benign
R4948:Dcp1a	UTSW	14	30,201,724 (GRCm39)	missense	probably damaging	1.00
R5541:Dcp1a	UTSW	14	30,224,796 (GRCm39)	missense	probably damaging	1.00
R6178:Dcp1a	UTSW	14	30,245,261 (GRCm39)	makesense	probably null
R7767:Dcp1a	UTSW	14	30,201,775 (GRCm39)	critical splice donor site	probably null
R7818:Dcp1a	UTSW	14	30,201,678 (GRCm39)	missense	probably damaging	0.99
R8248:Dcp1a	UTSW	14	30,244,883 (GRCm39)	missense	possibly damaging	0.87
R8248:Dcp1a	UTSW	14	30,201,555 (GRCm39)	intron	probably benign
R8250:Dcp1a	UTSW	14	30,244,883 (GRCm39)	missense	possibly damaging	0.87
R8271:Dcp1a	UTSW	14	30,244,883 (GRCm39)	missense	possibly damaging	0.87
R8297:Dcp1a	UTSW	14	30,244,883 (GRCm39)	missense	possibly damaging	0.87
R8302:Dcp1a	UTSW	14	30,244,883 (GRCm39)	missense	possibly damaging	0.87
R8326:Dcp1a	UTSW	14	30,241,527 (GRCm39)	nonsense	probably null
R8333:Dcp1a	UTSW	14	30,244,883 (GRCm39)	missense	possibly damaging	0.87
R8818:Dcp1a	UTSW	14	30,240,899 (GRCm39)	missense	possibly damaging	0.64
R9554:Dcp1a	UTSW	14	30,201,691 (GRCm39)	missense	probably benign	0.01
R9599:Dcp1a	UTSW	14	30,241,497 (GRCm39)	missense	probably benign
R9641:Dcp1a	UTSW	14	30,241,132 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16