Incidental Mutation 'R3934:Fgfr1op2'
ID 306941
Institutional Source Beutler Lab
Gene Symbol Fgfr1op2
Ensembl Gene ENSMUSG00000040242
Gene Name FGFR1 oncogene partner 2
Synonyms 1500031J01Rik
Accession Numbers
Essential gene? Possibly essential (E-score: 0.510) question?
Stock # R3934 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 146479401-146500696 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 146496669 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000107292 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037836] [ENSMUST00000058245] [ENSMUST00000067404] [ENSMUST00000111663]
AlphaFold Q9CRA9
Predicted Effect probably benign
Transcript: ENSMUST00000037836
SMART Domains Protein: ENSMUSP00000037316
Gene: ENSMUSG00000040242

DomainStartEndE-ValueType
Pfam:DUF837 1 142 4e-59 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000058245
SMART Domains Protein: ENSMUSP00000107289
Gene: ENSMUSG00000040242

DomainStartEndE-ValueType
Pfam:DUF837 1 142 4e-59 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000067404
SMART Domains Protein: ENSMUSP00000098352
Gene: ENSMUSG00000040242

DomainStartEndE-ValueType
Pfam:DUF837 1 185 8.6e-80 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000111663
SMART Domains Protein: ENSMUSP00000107292
Gene: ENSMUSG00000040242

DomainStartEndE-ValueType
Pfam:DUF837 2 221 2e-73 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160697
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.5%
Validation Efficiency 100% (40/40)
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5730507C01Rik T A 12: 18,584,082 (GRCm39) Y381N possibly damaging Het
Adgrf3 T C 5: 30,405,432 (GRCm39) probably benign Het
Adgrv1 A G 13: 81,623,166 (GRCm39) F3819S probably benign Het
Aig1 T C 10: 13,677,656 (GRCm39) D112G probably damaging Het
Akap6 C T 12: 53,187,227 (GRCm39) T1547M possibly damaging Het
Alk T A 17: 72,512,949 (GRCm39) I337F probably damaging Het
C2cd5 C T 6: 142,987,106 (GRCm39) V499I possibly damaging Het
Capn11 A T 17: 45,945,213 (GRCm39) probably benign Het
Clstn3 G A 6: 124,434,901 (GRCm39) T338I probably damaging Het
Cmbl A G 15: 31,589,933 (GRCm39) D221G possibly damaging Het
Enpp2 A G 15: 54,709,317 (GRCm39) V766A probably benign Het
Fastk G T 5: 24,647,257 (GRCm39) S317* probably null Het
Gpr85 A G 6: 13,836,044 (GRCm39) F287L probably benign Het
Hectd4 G A 5: 121,458,164 (GRCm39) probably null Het
Hmcn2 T A 2: 31,270,496 (GRCm39) probably null Het
Hspbp1 A T 7: 4,667,594 (GRCm39) M271K probably benign Het
Itgb6 G A 2: 60,441,755 (GRCm39) T685M possibly damaging Het
Itih5 G A 2: 10,250,355 (GRCm39) V685I probably damaging Het
Kalrn T C 16: 34,130,901 (GRCm39) S421G probably benign Het
Mcm2 G A 6: 88,869,990 (GRCm39) R60C probably damaging Het
Mitf C T 6: 97,970,214 (GRCm39) P54S probably damaging Het
Perm1 A G 4: 156,303,627 (GRCm39) T724A probably benign Het
Pex5l T C 3: 33,061,321 (GRCm39) E176G probably damaging Het
Polk A T 13: 96,638,143 (GRCm39) M192K possibly damaging Het
Polr3a T C 14: 24,526,169 (GRCm39) I401V probably benign Het
Prpf38b T C 3: 108,811,741 (GRCm39) probably benign Het
Sema3c T C 5: 17,886,938 (GRCm39) S330P probably damaging Het
Slc16a7 C A 10: 125,066,712 (GRCm39) R309L probably damaging Het
Slc35f1 C T 10: 52,984,314 (GRCm39) T358I probably damaging Het
Slc39a12 T A 2: 14,439,174 (GRCm39) probably benign Het
Sod3 T C 5: 52,525,987 (GRCm39) S229P probably benign Het
Sorcs3 T A 19: 48,701,943 (GRCm39) V608D probably damaging Het
Spink5 G T 18: 44,149,494 (GRCm39) K958N probably damaging Het
Ttc7 A C 17: 87,678,166 (GRCm39) probably benign Het
Ush2a T A 1: 187,995,708 (GRCm39) probably null Het
Vmn2r19 T A 6: 123,292,628 (GRCm39) D223E probably damaging Het
Vwf T A 6: 125,532,462 (GRCm39) S87T probably damaging Het
Wdr35 G T 12: 9,058,014 (GRCm39) G513C probably damaging Het
Other mutations in Fgfr1op2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02591:Fgfr1op2 APN 6 146,490,344 (GRCm39) missense probably damaging 0.97
IGL02626:Fgfr1op2 APN 6 146,491,509 (GRCm39) missense probably benign 0.37
IGL03081:Fgfr1op2 APN 6 146,498,817 (GRCm39) missense probably damaging 0.98
R1381:Fgfr1op2 UTSW 6 146,490,239 (GRCm39) missense probably damaging 1.00
R3740:Fgfr1op2 UTSW 6 146,496,731 (GRCm39) missense possibly damaging 0.94
R5471:Fgfr1op2 UTSW 6 146,498,860 (GRCm39) splice site probably null
R6842:Fgfr1op2 UTSW 6 146,491,536 (GRCm39) critical splice donor site probably null
R6988:Fgfr1op2 UTSW 6 146,491,463 (GRCm39) missense probably damaging 0.99
R9201:Fgfr1op2 UTSW 6 146,494,217 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- TCACGCAGACTTCAGGGAAG -3'
(R):5'- CCACCAACTTAAAGAGTGTGGG -3'

Sequencing Primer
(F):5'- CCCTTTTACCACAGTACATGTAGATG -3'
(R):5'- CCAACTTAAAGAGTGTGGGTGTTAAG -3'
Posted On 2015-04-17