Incidental Mutation 'IGL00469:Zfp984'
| ID |
332167 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp984
|
| Ensembl Gene |
ENSMUSG00000078495 |
| Gene Name |
zinc finger protein 984 |
| Synonyms |
Gm13157 |
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.461)
|
| Stock # |
IGL00469
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
4 |
| Chromosomal Location |
147838431-147894245 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 147839343 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glycine to Serine
at position 503
(G503S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000114023
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000105734]
[ENSMUST00000122309]
|
| AlphaFold |
A2A7A2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000105734
AA Change: G503S
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000101360
Gene: ENSMUSG00000078495
AA Change: G503S
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
13 |
72 |
5.24e-18 |
SMART |
|
ZnF_C2H2
|
238 |
260 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
266 |
288 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
294 |
316 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
322 |
344 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
350 |
372 |
4.24e-4 |
SMART |
|
ZnF_C2H2
|
378 |
400 |
3.69e-4 |
SMART |
|
ZnF_C2H2
|
406 |
428 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
434 |
456 |
3.39e-3 |
SMART |
|
ZnF_C2H2
|
462 |
484 |
1.3e-4 |
SMART |
|
ZnF_C2H2
|
490 |
512 |
1.4e-4 |
SMART |
|
ZnF_C2H2
|
518 |
540 |
4.79e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000122309
AA Change: G503S
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000114023
Gene: ENSMUSG00000078495
AA Change: G503S
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
13 |
72 |
5.24e-18 |
SMART |
|
ZnF_C2H2
|
238 |
260 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
266 |
288 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
294 |
316 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
322 |
344 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
350 |
372 |
4.24e-4 |
SMART |
|
ZnF_C2H2
|
378 |
400 |
3.69e-4 |
SMART |
|
ZnF_C2H2
|
406 |
428 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
434 |
456 |
3.39e-3 |
SMART |
|
ZnF_C2H2
|
462 |
484 |
1.3e-4 |
SMART |
|
ZnF_C2H2
|
490 |
512 |
1.4e-4 |
SMART |
|
ZnF_C2H2
|
518 |
540 |
4.79e-3 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 22 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Cacna2d4 |
A |
G |
6: 119,245,239 (GRCm39) |
I316V |
probably damaging |
Het |
| Ccdc9b |
T |
C |
2: 118,590,170 (GRCm39) |
S225G |
possibly damaging |
Het |
| Ccnb1ip1 |
G |
A |
14: 51,029,556 (GRCm39) |
R169C |
probably damaging |
Het |
| Crip1 |
G |
T |
12: 113,115,755 (GRCm39) |
D59Y |
probably damaging |
Het |
| Cstf2 |
T |
A |
X: 132,974,905 (GRCm39) |
H354Q |
probably damaging |
Het |
| Dcaf8l |
C |
A |
X: 88,449,944 (GRCm39) |
V62F |
possibly damaging |
Het |
| Dchs1 |
A |
T |
7: 105,404,468 (GRCm39) |
D2691E |
probably damaging |
Het |
| Dock2 |
T |
C |
11: 34,179,603 (GRCm39) |
|
probably benign |
Het |
| Fam199x |
T |
C |
X: 135,972,860 (GRCm39) |
I222T |
probably damaging |
Het |
| Flt1 |
A |
T |
5: 147,540,415 (GRCm39) |
L758Q |
probably damaging |
Het |
| Fxr2 |
T |
G |
11: 69,532,965 (GRCm39) |
L181R |
possibly damaging |
Het |
| Gpr158 |
G |
T |
2: 21,751,606 (GRCm39) |
|
probably benign |
Het |
| Hsd3b9 |
T |
A |
3: 98,363,716 (GRCm39) |
Q43L |
probably benign |
Het |
| Lancl2 |
T |
C |
6: 57,711,011 (GRCm39) |
W390R |
probably damaging |
Het |
| Pola1 |
C |
T |
X: 92,638,391 (GRCm39) |
V459I |
possibly damaging |
Het |
| Pola1 |
T |
C |
X: 92,604,991 (GRCm39) |
T981A |
probably damaging |
Het |
| Prss44 |
T |
C |
9: 110,644,557 (GRCm39) |
S222P |
probably benign |
Het |
| Sec16a |
T |
C |
2: 26,318,312 (GRCm39) |
N1593S |
probably damaging |
Het |
| Slco2b1 |
A |
G |
7: 99,309,318 (GRCm39) |
I671T |
probably benign |
Het |
| Tm9sf4 |
T |
C |
2: 153,044,275 (GRCm39) |
I509T |
probably damaging |
Het |
| Trpc6 |
A |
G |
9: 8,626,702 (GRCm39) |
T351A |
probably benign |
Het |
| Utrn |
T |
C |
10: 12,282,273 (GRCm39) |
Q768R |
probably damaging |
Het |
|
| Other mutations in Zfp984 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00428:Zfp984
|
APN |
4 |
147,839,343 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00550:Zfp984
|
APN |
4 |
147,839,343 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4791001:Zfp984
|
UTSW |
4 |
147,840,603 (GRCm39) |
missense |
probably benign |
0.15 |
|
R0281:Zfp984
|
UTSW |
4 |
147,839,722 (GRCm39) |
missense |
probably benign |
|
|
R0731:Zfp984
|
UTSW |
4 |
147,840,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1170:Zfp984
|
UTSW |
4 |
147,840,446 (GRCm39) |
missense |
probably benign |
0.24 |
|
R1293:Zfp984
|
UTSW |
4 |
147,840,398 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1518:Zfp984
|
UTSW |
4 |
147,840,002 (GRCm39) |
missense |
probably benign |
|
|
R2041:Zfp984
|
UTSW |
4 |
147,839,796 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2360:Zfp984
|
UTSW |
4 |
147,839,234 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5038:Zfp984
|
UTSW |
4 |
147,839,903 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5554:Zfp984
|
UTSW |
4 |
147,840,362 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6254:Zfp984
|
UTSW |
4 |
147,840,643 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R6418:Zfp984
|
UTSW |
4 |
147,845,703 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6527:Zfp984
|
UTSW |
4 |
147,840,381 (GRCm39) |
missense |
probably benign |
0.45 |
|
R6974:Zfp984
|
UTSW |
4 |
147,845,707 (GRCm39) |
start codon destroyed |
possibly damaging |
0.94 |
|
R7058:Zfp984
|
UTSW |
4 |
147,840,002 (GRCm39) |
missense |
probably benign |
|
|
R7495:Zfp984
|
UTSW |
4 |
147,839,287 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7843:Zfp984
|
UTSW |
4 |
147,842,165 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8462:Zfp984
|
UTSW |
4 |
147,839,796 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8520:Zfp984
|
UTSW |
4 |
147,840,668 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8918:Zfp984
|
UTSW |
4 |
147,840,623 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R9387:Zfp984
|
UTSW |
4 |
147,840,002 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Zfp984
|
UTSW |
4 |
147,839,921 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1177:Zfp984
|
UTSW |
4 |
147,840,577 (GRCm39) |
missense |
probably benign |
0.04 |
|
| Posted On |
2015-08-05 |
Incidental Mutation