Incidental Mutation 'R1293:Zfp984'
| ID |
150699 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp984
|
| Ensembl Gene |
ENSMUSG00000078495 |
| Gene Name |
zinc finger protein 984 |
| Synonyms |
Gm13157 |
| MMRRC Submission |
039359-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.461)
|
| Stock # |
R1293 (G1)
|
| Quality Score |
127 |
|
Status
|
Not validated
|
| Chromosome |
4 |
| Chromosomal Location |
147838431-147894245 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 147840398 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Methionine
at position 151
(K151M)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000114023
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000105734]
[ENSMUST00000122309]
|
| AlphaFold |
A2A7A2 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000105734
AA Change: K151M
PolyPhen 2
Score 0.850 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000101360
Gene: ENSMUSG00000078495
AA Change: K151M
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
13 |
72 |
5.24e-18 |
SMART |
|
ZnF_C2H2
|
238 |
260 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
266 |
288 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
294 |
316 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
322 |
344 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
350 |
372 |
4.24e-4 |
SMART |
|
ZnF_C2H2
|
378 |
400 |
3.69e-4 |
SMART |
|
ZnF_C2H2
|
406 |
428 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
434 |
456 |
3.39e-3 |
SMART |
|
ZnF_C2H2
|
462 |
484 |
1.3e-4 |
SMART |
|
ZnF_C2H2
|
490 |
512 |
1.4e-4 |
SMART |
|
ZnF_C2H2
|
518 |
540 |
4.79e-3 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000122309
AA Change: K151M
PolyPhen 2
Score 0.850 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000114023
Gene: ENSMUSG00000078495
AA Change: K151M
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
13 |
72 |
5.24e-18 |
SMART |
|
ZnF_C2H2
|
238 |
260 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
266 |
288 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
294 |
316 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
322 |
344 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
350 |
372 |
4.24e-4 |
SMART |
|
ZnF_C2H2
|
378 |
400 |
3.69e-4 |
SMART |
|
ZnF_C2H2
|
406 |
428 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
434 |
456 |
3.39e-3 |
SMART |
|
ZnF_C2H2
|
462 |
484 |
1.3e-4 |
SMART |
|
ZnF_C2H2
|
490 |
512 |
1.4e-4 |
SMART |
|
ZnF_C2H2
|
518 |
540 |
4.79e-3 |
SMART |
|
| Coding Region Coverage |
- 1x: 98.9%
- 3x: 98.1%
- 10x: 95.7%
- 20x: 90.5%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 30 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acss2 |
G |
A |
2: 155,393,141 (GRCm39) |
R289Q |
probably benign |
Het |
| Adgrl4 |
G |
A |
3: 151,213,081 (GRCm39) |
E374K |
probably benign |
Het |
| Ate1 |
G |
A |
7: 129,996,455 (GRCm39) |
R505C |
probably benign |
Het |
| Cntn4 |
T |
C |
6: 106,330,685 (GRCm39) |
I101T |
probably benign |
Het |
| Dmtf1 |
T |
A |
5: 9,190,383 (GRCm39) |
|
probably null |
Het |
| Dnah17 |
C |
A |
11: 118,017,963 (GRCm39) |
|
probably null |
Het |
| Efhc1 |
A |
G |
1: 21,048,996 (GRCm39) |
T470A |
probably damaging |
Het |
| Fam118b |
A |
T |
9: 35,132,721 (GRCm39) |
Y313N |
probably damaging |
Het |
| Gm10142 |
T |
C |
10: 77,551,869 (GRCm39) |
S77P |
probably benign |
Het |
| Kat8 |
T |
C |
7: 127,521,422 (GRCm39) |
|
probably null |
Het |
| Lrp2 |
T |
C |
2: 69,353,646 (GRCm39) |
|
probably null |
Het |
| Lrrc10 |
A |
G |
10: 116,881,838 (GRCm39) |
T171A |
probably benign |
Het |
| Mcidas |
A |
G |
13: 113,133,926 (GRCm39) |
T137A |
probably benign |
Het |
| Med1 |
G |
A |
11: 98,047,862 (GRCm39) |
T978I |
possibly damaging |
Het |
| Muc6 |
C |
A |
7: 141,238,255 (GRCm39) |
C75F |
probably damaging |
Het |
| Olfm3 |
A |
G |
3: 114,895,579 (GRCm39) |
I154V |
possibly damaging |
Het |
| Or2ag15 |
A |
G |
7: 106,341,058 (GRCm39) |
C28R |
probably damaging |
Het |
| Or2y12 |
G |
A |
11: 49,426,393 (GRCm39) |
C127Y |
probably damaging |
Het |
| Or5ak22 |
T |
A |
2: 85,230,697 (GRCm39) |
|
probably null |
Het |
| Or7g30 |
A |
T |
9: 19,352,728 (GRCm39) |
E173V |
probably benign |
Het |
| Rsrc1 |
G |
A |
3: 67,263,612 (GRCm39) |
R324Q |
probably damaging |
Het |
| Samd9l |
G |
T |
6: 3,373,947 (GRCm39) |
P1105T |
possibly damaging |
Het |
| Sgcb |
C |
A |
5: 73,792,870 (GRCm39) |
V311F |
probably benign |
Het |
| Siglec1 |
A |
G |
2: 130,915,451 (GRCm39) |
V1380A |
probably benign |
Het |
| Spred1 |
C |
T |
2: 117,007,889 (GRCm39) |
P265L |
probably damaging |
Het |
| Unc13b |
T |
A |
4: 43,235,190 (GRCm39) |
H3259Q |
probably damaging |
Het |
| Unc13c |
C |
T |
9: 73,481,356 (GRCm39) |
D1694N |
probably benign |
Het |
| Usp24 |
A |
G |
4: 106,280,750 (GRCm39) |
R2355G |
probably benign |
Het |
| Vmn1r53 |
T |
A |
6: 90,201,196 (GRCm39) |
N43Y |
possibly damaging |
Het |
| Wtip |
T |
C |
7: 33,809,646 (GRCm39) |
S359G |
possibly damaging |
Het |
|
| Other mutations in Zfp984 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00428:Zfp984
|
APN |
4 |
147,839,343 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00469:Zfp984
|
APN |
4 |
147,839,343 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00550:Zfp984
|
APN |
4 |
147,839,343 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4791001:Zfp984
|
UTSW |
4 |
147,840,603 (GRCm39) |
missense |
probably benign |
0.15 |
|
R0281:Zfp984
|
UTSW |
4 |
147,839,722 (GRCm39) |
missense |
probably benign |
|
|
R0731:Zfp984
|
UTSW |
4 |
147,840,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1170:Zfp984
|
UTSW |
4 |
147,840,446 (GRCm39) |
missense |
probably benign |
0.24 |
|
R1518:Zfp984
|
UTSW |
4 |
147,840,002 (GRCm39) |
missense |
probably benign |
|
|
R2041:Zfp984
|
UTSW |
4 |
147,839,796 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2360:Zfp984
|
UTSW |
4 |
147,839,234 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5038:Zfp984
|
UTSW |
4 |
147,839,903 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5554:Zfp984
|
UTSW |
4 |
147,840,362 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6254:Zfp984
|
UTSW |
4 |
147,840,643 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R6418:Zfp984
|
UTSW |
4 |
147,845,703 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6527:Zfp984
|
UTSW |
4 |
147,840,381 (GRCm39) |
missense |
probably benign |
0.45 |
|
R6974:Zfp984
|
UTSW |
4 |
147,845,707 (GRCm39) |
start codon destroyed |
possibly damaging |
0.94 |
|
R7058:Zfp984
|
UTSW |
4 |
147,840,002 (GRCm39) |
missense |
probably benign |
|
|
R7495:Zfp984
|
UTSW |
4 |
147,839,287 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7843:Zfp984
|
UTSW |
4 |
147,842,165 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8462:Zfp984
|
UTSW |
4 |
147,839,796 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8520:Zfp984
|
UTSW |
4 |
147,840,668 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8918:Zfp984
|
UTSW |
4 |
147,840,623 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R9387:Zfp984
|
UTSW |
4 |
147,840,002 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Zfp984
|
UTSW |
4 |
147,839,921 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1177:Zfp984
|
UTSW |
4 |
147,840,577 (GRCm39) |
missense |
probably benign |
0.04 |
|
| Predicted Primers |
|
| Posted On |
2014-01-29 |
Incidental Mutation