Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00493:Sirpb1a'

332226

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Sirpb1a

Ensembl Gene

ENSMUSG00000095788

Gene Name

signal-regulatory protein beta 1A

Synonyms

9930027N05Rik, Sirpb1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.061) question?

Stock #

IGL00493

Quality Score

Status

Chromosome

Chromosomal Location

15436887-15491487 bp(-) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

G to A at 15475788 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000141659 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099201] [ENSMUST00000192700] [ENSMUST00000194144]

AlphaFold

A0A0A6YYP6

Predicted Effect

probably benign
Transcript: ENSMUST00000099201

SMART Domains

Protein: ENSMUSP00000096807
Gene: ENSMUSG00000095788

Domain	Start	End	E-Value	Type
low complexity region	15	21	N/A	INTRINSIC
IG	37	143	2.48e-8	SMART
IGc1	163	236	1.17e-4	SMART
IGc1	269	339	4.91e-4	SMART
transmembrane domain	364	386	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000191958

Predicted Effect

probably benign
Transcript: ENSMUST00000192700

SMART Domains

Protein: ENSMUSP00000141504
Gene: ENSMUSG00000095788

Domain	Start	End	E-Value	Type
low complexity region	15	21	N/A	INTRINSIC
IG	37	143	2.48e-8	SMART
IGc1	163	236	1.17e-4	SMART
IGc1	269	339	4.91e-4	SMART
transmembrane domain	364	386	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000194144

SMART Domains

Protein: ENSMUSP00000141659
Gene: ENSMUSG00000095788

Domain	Start	End	E-Value	Type
Pfam:Ig_2	15	66	6.6e-1	PFAM
Pfam:Ig_3	21	52	1.7e-2	PFAM
Pfam:V-set	23	75	1.2e-7	PFAM
IGc1	96	169	4.8e-7	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adarb2	A	G	13: 8,751,761 (GRCm39)	T509A	probably benign	Het
Arhgap23	T	C	11: 97,337,379 (GRCm39)		probably null	Het
Astn1	A	T	1: 158,427,889 (GRCm39)	I687F	possibly damaging	Het
Atg4d	T	C	9: 21,178,217 (GRCm39)	F112L	probably damaging	Het
Bltp3b	A	C	10: 89,615,846 (GRCm39)	D163A	probably damaging	Het
Cd200	T	A	16: 45,217,409 (GRCm39)	D94V	probably damaging	Het
Cfap46	T	C	7: 139,194,359 (GRCm39)	K2285R	probably benign	Het
Clhc1	T	A	11: 29,521,745 (GRCm39)	I426N	probably damaging	Het
Cnnm2	T	A	19: 46,751,659 (GRCm39)	V483E	probably damaging	Het
Dennd2b	G	A	7: 109,126,915 (GRCm39)	A932V	possibly damaging	Het
Dlc1	A	T	8: 37,037,436 (GRCm39)		probably benign	Het
Fpgs	T	C	2: 32,578,009 (GRCm39)	I138V	possibly damaging	Het
Gpr152	T	C	19: 4,193,506 (GRCm39)	V349A	probably benign	Het
Hk1	C	A	10: 62,122,127 (GRCm39)	E523*	probably null	Het
Ift70a1	C	A	2: 75,812,085 (GRCm39)		probably benign	Het
Krt6a	T	G	15: 101,601,229 (GRCm39)	K241N	probably damaging	Het
Mcm3ap	A	G	10: 76,307,011 (GRCm39)	S375G	probably benign	Het
Meikin	C	T	11: 54,289,320 (GRCm39)	P231L	probably damaging	Het
Micall1	G	A	15: 78,999,221 (GRCm39)		probably benign	Het
Mvk	G	A	5: 114,583,502 (GRCm39)	V14I	probably benign	Het
Myo6	C	T	9: 80,199,754 (GRCm39)	S1021L	probably damaging	Het
N4bp2l2	G	A	5: 150,585,401 (GRCm39)	T193M	probably benign	Het
Naip5	G	T	13: 100,367,279 (GRCm39)	D272E	probably damaging	Het
Nptn	T	A	9: 58,550,922 (GRCm39)	N316K	probably damaging	Het
Pde6c	T	C	19: 38,151,324 (GRCm39)		probably benign	Het
Prg4	T	A	1: 150,327,671 (GRCm39)	I850L	probably damaging	Het
Rdm1	T	G	11: 101,526,580 (GRCm39)	C251G	possibly damaging	Het
Relch	A	G	1: 105,624,324 (GRCm39)		probably benign	Het
Rps6kl1	G	A	12: 85,186,157 (GRCm39)	P291L	probably benign	Het
Sel1l	A	G	12: 91,781,387 (GRCm39)		probably benign	Het
Serpinb1b	T	C	13: 33,277,850 (GRCm39)	F361S	probably damaging	Het
Smpd1	T	G	7: 105,205,848 (GRCm39)	V405G	probably damaging	Het
Spmip11	T	C	15: 98,486,425 (GRCm39)		probably benign	Het
Tead3	T	C	17: 28,551,780 (GRCm39)	T438A	possibly damaging	Het
Treh	A	T	9: 44,595,197 (GRCm39)	D89V	probably damaging	Het
Trim10	A	T	17: 37,188,140 (GRCm39)	H452L	probably benign	Het
Ugt2b1	A	G	5: 87,073,817 (GRCm39)	C181R	probably benign	Het
Xdh	A	T	17: 74,230,101 (GRCm39)	F277I	possibly damaging	Het
Zswim4	T	G	8: 84,938,769 (GRCm39)	T1038P	probably damaging	Het

Other mutations in Sirpb1a

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00597:Sirpb1a	APN	3	15,481,977 (GRCm39)	missense	probably damaging	1.00
IGL01521:Sirpb1a	APN	3	15,475,561 (GRCm39)	missense	probably benign	0.00
IGL01678:Sirpb1a	APN	3	15,476,370 (GRCm39)	missense	probably damaging	1.00
IGL02154:Sirpb1a	APN	3	15,475,504 (GRCm39)	missense	probably damaging	1.00
IGL02275:Sirpb1a	APN	3	15,475,469 (GRCm39)	critical splice donor site	probably null
IGL02419:Sirpb1a	APN	3	15,491,398 (GRCm39)	missense	probably benign
IGL02657:Sirpb1a	APN	3	15,482,111 (GRCm39)	missense	possibly damaging	0.85
IGL03086:Sirpb1a	APN	3	15,491,388 (GRCm39)	splice site	probably null
PIT4142001:Sirpb1a	UTSW	3	15,476,258 (GRCm39)	missense	probably benign	0.00
R0270:Sirpb1a	UTSW	3	15,475,587 (GRCm39)	missense	probably damaging	1.00
R1975:Sirpb1a	UTSW	3	15,444,141 (GRCm39)	missense	probably benign	0.00
R3432:Sirpb1a	UTSW	3	15,491,447 (GRCm39)	missense	probably damaging	0.98
R4613:Sirpb1a	UTSW	3	15,482,097 (GRCm39)	missense	probably benign	0.09
R5325:Sirpb1a	UTSW	3	15,476,503 (GRCm39)	missense	possibly damaging	0.90
R6223:Sirpb1a	UTSW	3	15,444,086 (GRCm39)	missense	probably benign	0.02
R6526:Sirpb1a	UTSW	3	15,444,080 (GRCm39)	missense	probably damaging	0.99
R6903:Sirpb1a	UTSW	3	15,481,984 (GRCm39)	missense	probably damaging	0.99
R7349:Sirpb1a	UTSW	3	15,475,664 (GRCm39)	missense	probably damaging	0.99
R7513:Sirpb1a	UTSW	3	15,476,503 (GRCm39)	missense	possibly damaging	0.90
R8250:Sirpb1a	UTSW	3	15,444,104 (GRCm39)	missense	possibly damaging	0.92
R8700:Sirpb1a	UTSW	3	15,476,419 (GRCm39)	missense	probably damaging	0.97
R9263:Sirpb1a	UTSW	3	15,481,992 (GRCm39)	missense	probably damaging	1.00
R9553:Sirpb1a	UTSW	3	15,476,320 (GRCm39)	missense	probably damaging	0.99

Posted On

2015-08-05