Incidental Mutation 'R4522:Rpl10l'
ID 334274
Institutional Source Beutler Lab
Gene Symbol Rpl10l
Ensembl Gene ENSMUSG00000060499
Gene Name ribosomal protein L10-like
Synonyms EG238217
MMRRC Submission 041765-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.674) question?
Stock # R4522 (G1)
Quality Score 225
Status Not validated
Chromosome 12
Chromosomal Location 66330153-66331175 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 66330512 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 207 (D207G)
Ref Sequence ENSEMBL: ENSMUSP00000100795 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081908]
AlphaFold P86048
Predicted Effect probably benign
Transcript: ENSMUST00000081908
AA Change: D207G

PolyPhen 2 Score 0.190 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000100795
Gene: ENSMUSG00000060499
AA Change: D207G

DomainStartEndE-ValueType
Pfam:Ribosomal_L16 12 166 4.6e-45 PFAM
Meta Mutation Damage Score 0.0627 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein sharing sequence similarity with ribosomal protein L10. It is not currently known whether the encoded protein is a functional ribosomal protein or whether it has evolved a function that is independent of the ribosome. This gene is intronless. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ascc3 A G 10: 50,536,766 (GRCm39) N700D probably benign Het
Babam2 G A 5: 32,164,586 (GRCm39) V287M probably damaging Het
Brip1 T C 11: 86,080,627 (GRCm39) I146M possibly damaging Het
Cacna1b C T 2: 24,544,442 (GRCm39) R1248H probably damaging Het
Ccdc88c G T 12: 100,879,591 (GRCm39) S1843R possibly damaging Het
Cfap47 A T X: 78,553,601 (GRCm39) N291K possibly damaging Het
Chaf1b G A 16: 93,698,183 (GRCm39) A485T probably benign Het
Dock7 T C 4: 98,850,461 (GRCm39) R1594G probably damaging Het
Fbxo41 A G 6: 85,461,024 (GRCm39) I228T probably damaging Het
Gm3739 T A 14: 18,505,267 (GRCm39) K86* probably null Het
Mark2 A T 19: 7,263,313 (GRCm39) D151E probably damaging Het
Nop2 G T 6: 125,110,515 (GRCm39) R47L probably damaging Het
Nwd1 A T 8: 73,397,579 (GRCm39) D606V probably damaging Het
Or8w1 T A 2: 87,465,495 (GRCm39) I199L probably benign Het
Pabir3 G A X: 52,382,376 (GRCm39) R94H possibly damaging Het
Pcbp1 T C 6: 86,502,032 (GRCm39) N289S probably benign Het
Plce1 T C 19: 38,512,763 (GRCm39) S21P possibly damaging Het
Ptpn18 T C 1: 34,512,041 (GRCm39) L55P probably benign Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Sec23b T A 2: 144,420,286 (GRCm39) I450N possibly damaging Het
Speg A G 1: 75,404,974 (GRCm39) E2922G probably damaging Het
Spem1 C A 11: 69,712,631 (GRCm39) probably null Het
Stxbp3-ps A T 19: 9,536,474 (GRCm39) noncoding transcript Het
Tmem38a C T 8: 73,326,005 (GRCm39) P20S possibly damaging Het
Tmod2 T C 9: 75,499,866 (GRCm39) T129A probably benign Het
Ttc28 A G 5: 111,428,038 (GRCm39) T1845A probably benign Het
Ubqlnl C T 7: 103,798,925 (GRCm39) V191M probably benign Het
Ush2a C T 1: 188,596,822 (GRCm39) T3854M probably damaging Het
Vmn2r72 T A 7: 85,401,134 (GRCm39) H95L probably benign Het
Xdh C A 17: 74,205,339 (GRCm39) G1042V probably damaging Het
Zfp105 T A 9: 122,759,121 (GRCm39) V264E possibly damaging Het
Other mutations in Rpl10l
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01013:Rpl10l APN 12 66,331,001 (GRCm39) missense probably benign 0.00
G1citation:Rpl10l UTSW 12 66,330,987 (GRCm39) missense possibly damaging 0.93
R0278:Rpl10l UTSW 12 66,331,130 (GRCm39) start codon destroyed probably null 0.99
R4043:Rpl10l UTSW 12 66,330,977 (GRCm39) missense probably damaging 0.99
R4520:Rpl10l UTSW 12 66,330,512 (GRCm39) missense probably benign 0.19
R4521:Rpl10l UTSW 12 66,330,512 (GRCm39) missense probably benign 0.19
R4523:Rpl10l UTSW 12 66,330,512 (GRCm39) missense probably benign 0.19
R4524:Rpl10l UTSW 12 66,330,512 (GRCm39) missense probably benign 0.19
R6822:Rpl10l UTSW 12 66,330,987 (GRCm39) missense possibly damaging 0.93
R7682:Rpl10l UTSW 12 66,331,004 (GRCm39) missense probably benign 0.03
R7773:Rpl10l UTSW 12 66,331,041 (GRCm39) missense probably benign 0.18
Predicted Primers PCR Primer
(F):5'- TGCTACACTGCAGTATACACC -3'
(R):5'- GTCATCATGTCCATCCGCAC -3'

Sequencing Primer
(F):5'- CACCAAAAATTTTAAGTACATGGGTC -3'
(R):5'- CACGTGATCGAGGCCCTAC -3'
Posted On 2015-08-18