Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01013:Rpl10l'

53907

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Rpl10l

Ensembl Gene

ENSMUSG00000060499

Gene Name

ribosomal protein L10-like

Synonyms

EG238217

Accession Numbers

Essential gene?

Possibly essential (E-score: 0.674) question?

Stock #

IGL01013

Quality Score

Status

Chromosome

Chromosomal Location

66330153-66331175 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 66331001 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 44 (D44G)

Ref Sequence

ENSEMBL: ENSMUSP00000100795 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000081908]

AlphaFold

P86048

Predicted Effect

probably benign
Transcript: ENSMUST00000081908
AA Change: D44G

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)

SMART Domains

Protein: ENSMUSP00000100795
Gene: ENSMUSG00000060499
AA Change: D44G

Domain	Start	End	E-Value	Type
Pfam:Ribosomal_L16	12	166	4.6e-45	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein sharing sequence similarity with ribosomal protein L10. It is not currently known whether the encoded protein is a functional ribosomal protein or whether it has evolved a function that is independent of the ribosome. This gene is intronless. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aasdh	T	A	5: 77,034,053 (GRCm39)	E499D	possibly damaging	Het
Abca1	A	T	4: 53,038,185 (GRCm39)	L2059*	probably null	Het
Ankar	T	A	1: 72,690,148 (GRCm39)	I1228F	possibly damaging	Het
Appl1	A	T	14: 26,671,433 (GRCm39)	Y340N	possibly damaging	Het
Atp8b4	C	A	2: 126,165,007 (GRCm39)	R1103L	probably benign	Het
B4galt6	A	G	18: 20,822,070 (GRCm39)	V308A	probably damaging	Het
Ccdc162	G	A	10: 41,457,335 (GRCm39)	P1534L	probably benign	Het
Ccdc78	A	G	17: 26,008,028 (GRCm39)	E313G	possibly damaging	Het
Cep57l1	G	A	10: 41,616,865 (GRCm39)	R141*	probably null	Het
Cpsf1	G	A	15: 76,483,497 (GRCm39)	Q883*	probably null	Het
Crot	A	G	5: 9,043,575 (GRCm39)	Y16H	probably benign	Het
Cyld	T	G	8: 89,468,990 (GRCm39)	L587R	probably damaging	Het
Fam114a1	G	A	5: 65,188,738 (GRCm39)		probably null	Het
Fam89b	G	T	19: 5,779,397 (GRCm39)	D53E	probably benign	Het
Fig4	T	C	10: 41,143,782 (GRCm39)	M226V	probably benign	Het
Gm10722	A	T	9: 3,002,230 (GRCm39)	Y184F	probably damaging	Het
Hp	C	A	8: 110,305,653 (GRCm39)		probably benign	Het
Igsf9b	G	T	9: 27,245,600 (GRCm39)	R1189L	probably damaging	Het
Ilf3	A	G	9: 21,310,987 (GRCm39)	N620D	possibly damaging	Het
Jakmip3	A	C	7: 138,619,302 (GRCm39)	E228A	possibly damaging	Het
Kpna3	A	T	14: 61,607,966 (GRCm39)	I413K	probably damaging	Het
Letm1	A	T	5: 33,919,934 (GRCm39)	C202S	possibly damaging	Het
Lmod2	C	A	6: 24,604,134 (GRCm39)	Q370K	probably damaging	Het
Map4k5	T	C	12: 69,874,300 (GRCm39)		probably benign	Het
Mcidas	T	A	13: 113,134,119 (GRCm39)		probably benign	Het
Mme	A	G	3: 63,235,281 (GRCm39)		probably null	Het
Mrc1	T	C	2: 14,333,236 (GRCm39)	W1306R	probably damaging	Het
Mthfd1l	C	A	10: 3,980,716 (GRCm39)	Q473K	probably damaging	Het
Muc6	A	T	7: 141,234,333 (GRCm39)	C719*	probably null	Het
Nsun7	T	C	5: 66,440,944 (GRCm39)	I355T	possibly damaging	Het
Padi6	A	G	4: 140,456,314 (GRCm39)	L560P	probably damaging	Het
Parl	C	A	16: 20,101,540 (GRCm39)	A285S	possibly damaging	Het
Pclo	A	T	5: 14,843,848 (GRCm39)	M4795L	unknown	Het
Polr2f	A	G	15: 79,030,329 (GRCm39)	Y56C	probably damaging	Het
Rasgrp2	A	T	19: 6,454,413 (GRCm39)	H152L	probably damaging	Het
Slc25a16	A	G	10: 62,780,212 (GRCm39)		probably null	Het
Snrnp200	G	A	2: 127,074,392 (GRCm39)	E1411K	probably damaging	Het
Tanc2	G	A	11: 105,515,891 (GRCm39)	R3Q	probably damaging	Het
Tbc1d32	G	T	10: 56,078,055 (GRCm39)		probably null	Het
Tcf7l2	T	C	19: 55,908,059 (GRCm39)		probably benign	Het
Tnrc6c	G	T	11: 117,612,855 (GRCm39)	V498L	probably benign	Het
Tymp	G	A	15: 89,260,513 (GRCm39)	H102Y	probably damaging	Het
Wdr76	T	C	2: 121,365,978 (GRCm39)	S492P	probably benign	Het
Zc3h12d	T	C	10: 7,715,720 (GRCm39)	I41T	probably damaging	Het

Other mutations in Rpl10l

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
G1citation:Rpl10l	UTSW	12	66,330,987 (GRCm39)	missense	possibly damaging	0.93
R0278:Rpl10l	UTSW	12	66,331,130 (GRCm39)	start codon destroyed	probably null	0.99
R4043:Rpl10l	UTSW	12	66,330,977 (GRCm39)	missense	probably damaging	0.99
R4520:Rpl10l	UTSW	12	66,330,512 (GRCm39)	missense	probably benign	0.19
R4521:Rpl10l	UTSW	12	66,330,512 (GRCm39)	missense	probably benign	0.19
R4522:Rpl10l	UTSW	12	66,330,512 (GRCm39)	missense	probably benign	0.19
R4523:Rpl10l	UTSW	12	66,330,512 (GRCm39)	missense	probably benign	0.19
R4524:Rpl10l	UTSW	12	66,330,512 (GRCm39)	missense	probably benign	0.19
R6822:Rpl10l	UTSW	12	66,330,987 (GRCm39)	missense	possibly damaging	0.93
R7682:Rpl10l	UTSW	12	66,331,004 (GRCm39)	missense	probably benign	0.03
R7773:Rpl10l	UTSW	12	66,331,041 (GRCm39)	missense	probably benign	0.18

Posted On

2013-06-28