Incidental Mutation 'R0227:Tafa5'
ID 34010
Institutional Source Beutler Lab
Gene Symbol Tafa5
Ensembl Gene ENSMUSG00000054863
Gene Name TAFA chemokine like family member 5
Synonyms Tara-5, Fam19a5
MMRRC Submission 038472-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.096) question?
Stock # R0227 (G1)
Quality Score 219
Status Validated
Chromosome 15
Chromosomal Location 87428500-87643565 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to C at 87604691 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000155322 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068088] [ENSMUST00000230414]
AlphaFold Q91WE9
Predicted Effect probably benign
Transcript: ENSMUST00000068088
SMART Domains Protein: ENSMUSP00000064808
Gene: ENSMUSG00000054863

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
Pfam:TAFA 35 124 1.1e-47 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000230414
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.5%
  • 20x: 93.5%
Validation Efficiency 86% (37/43)
MGI Phenotype FUNCTION: This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9430038I01Rik A T 7: 136,989,438 (GRCm39) probably benign Het
Ankrd12 T A 17: 66,294,222 (GRCm39) T404S probably benign Het
Ap4m1 T C 5: 138,174,538 (GRCm39) probably benign Het
Atn1 A T 6: 124,723,893 (GRCm39) probably benign Het
Bcl9l A G 9: 44,416,533 (GRCm39) Y202C possibly damaging Het
Ceacam18 G T 7: 43,288,815 (GRCm39) G189C probably damaging Het
Cfap65 C T 1: 74,971,117 (GRCm39) W67* probably null Het
Col2a1 C T 15: 97,874,636 (GRCm39) E1334K unknown Het
Crim1 A G 17: 78,651,938 (GRCm39) probably benign Het
Csmd1 A G 8: 16,441,836 (GRCm39) S343P probably benign Het
D430041D05Rik G T 2: 104,035,545 (GRCm39) D1594E possibly damaging Het
Ess2 C T 16: 17,720,135 (GRCm39) V406I probably damaging Het
Gcm2 C T 13: 41,259,332 (GRCm39) V46M probably damaging Het
Gm3486 A T 14: 41,206,518 (GRCm39) V185E probably benign Het
Gtf3a C A 5: 146,892,199 (GRCm39) R317S probably damaging Het
Ice2 A G 9: 69,319,510 (GRCm39) I320V probably benign Het
Jag1 A G 2: 136,957,538 (GRCm39) V58A probably benign Het
Macf1 T C 4: 123,293,184 (GRCm39) E1241G probably benign Het
Mogat2 T A 7: 98,872,339 (GRCm39) I171F probably benign Het
Muc6 G A 7: 141,223,981 (GRCm39) probably benign Het
Myo1c A T 11: 75,549,520 (GRCm39) Y201F probably benign Het
Myo9b A G 8: 71,796,806 (GRCm39) I884V probably damaging Het
Nudt9 T C 5: 104,209,541 (GRCm39) I264T possibly damaging Het
Or8g30 A G 9: 39,229,974 (GRCm39) V312A probably benign Het
Pdcd11 AGAGGAGGAGGAGGAGGAGGAGGAG AGAGGAGGAGGAGGAGGAGGAG 19: 47,101,876 (GRCm39) probably benign Het
Rabgef1 T C 5: 130,219,831 (GRCm39) V98A probably damaging Het
Raly A G 2: 154,707,841 (GRCm39) D287G probably damaging Het
Raph1 A G 1: 60,565,136 (GRCm39) V117A probably benign Het
Slc34a2 T C 5: 53,226,968 (GRCm39) F697S possibly damaging Het
Son T A 16: 91,453,761 (GRCm39) M836K probably damaging Het
Spock1 T C 13: 57,588,290 (GRCm39) M258V possibly damaging Het
Stk10 G T 11: 32,567,859 (GRCm39) C887F probably damaging Het
Synpo2 A G 3: 122,907,442 (GRCm39) S625P probably benign Het
Synrg T A 11: 83,900,258 (GRCm39) D821E probably damaging Het
Tg C A 15: 66,570,295 (GRCm39) A1389E possibly damaging Het
Tspan33 G A 6: 29,713,477 (GRCm39) V134M probably damaging Het
Ubr4 T C 4: 139,158,960 (GRCm39) F2438L probably benign Het
Vmn1r210 C T 13: 23,011,561 (GRCm39) V242I probably benign Het
Vmn1r63 C T 7: 5,805,741 (GRCm39) W297* probably null Het
Vmn2r92 C T 17: 18,388,219 (GRCm39) A408V probably damaging Het
Zic5 A G 14: 122,697,073 (GRCm39) I514T unknown Het
Other mutations in Tafa5
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0305:Tafa5 UTSW 15 87,604,709 (GRCm39) missense probably damaging 1.00
R1405:Tafa5 UTSW 15 87,565,678 (GRCm39) splice site probably benign
R4646:Tafa5 UTSW 15 87,604,783 (GRCm39) missense probably damaging 0.99
R4647:Tafa5 UTSW 15 87,604,783 (GRCm39) missense probably damaging 0.99
R4841:Tafa5 UTSW 15 87,509,637 (GRCm39) intron probably benign
R9147:Tafa5 UTSW 15 87,428,775 (GRCm39) missense probably benign 0.05
R9148:Tafa5 UTSW 15 87,428,775 (GRCm39) missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- TGGGGACCAATGATTCTACACCCAG -3'
(R):5'- GATTCGGAACAGGCTCTCTGACAC -3'

Sequencing Primer
(F):5'- TGATTCTACACCCAGGAGAGAC -3'
(R):5'- CTGACACTTATTCACAGAGAGTGAGG -3'
Posted On 2013-05-09