Incidental Mutation 'R0227:Vmn1r210'
ID 34005
Institutional Source Beutler Lab
Gene Symbol Vmn1r210
Ensembl Gene ENSMUSG00000061296
Gene Name vomeronasal 1 receptor 210
Synonyms V1rh10
MMRRC Submission 038472-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # R0227 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 23011364-23012284 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 23011561 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 242 (V242I)
Ref Sequence ENSEMBL: ENSMUSP00000153776 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072044] [ENSMUST00000226180] [ENSMUST00000226294]
AlphaFold Q8R274
Predicted Effect probably benign
Transcript: ENSMUST00000072044
AA Change: V242I

PolyPhen 2 Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000071925
Gene: ENSMUSG00000061296
AA Change: V242I

DomainStartEndE-ValueType
Pfam:V1R 34 297 8.6e-38 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000226180
AA Change: V242I

PolyPhen 2 Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)
Predicted Effect probably benign
Transcript: ENSMUST00000226294
AA Change: V242I

PolyPhen 2 Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.5%
  • 20x: 93.5%
Validation Efficiency 86% (37/43)
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9430038I01Rik A T 7: 136,989,438 (GRCm39) probably benign Het
Ankrd12 T A 17: 66,294,222 (GRCm39) T404S probably benign Het
Ap4m1 T C 5: 138,174,538 (GRCm39) probably benign Het
Atn1 A T 6: 124,723,893 (GRCm39) probably benign Het
Bcl9l A G 9: 44,416,533 (GRCm39) Y202C possibly damaging Het
Ceacam18 G T 7: 43,288,815 (GRCm39) G189C probably damaging Het
Cfap65 C T 1: 74,971,117 (GRCm39) W67* probably null Het
Col2a1 C T 15: 97,874,636 (GRCm39) E1334K unknown Het
Crim1 A G 17: 78,651,938 (GRCm39) probably benign Het
Csmd1 A G 8: 16,441,836 (GRCm39) S343P probably benign Het
D430041D05Rik G T 2: 104,035,545 (GRCm39) D1594E possibly damaging Het
Ess2 C T 16: 17,720,135 (GRCm39) V406I probably damaging Het
Gcm2 C T 13: 41,259,332 (GRCm39) V46M probably damaging Het
Gm3486 A T 14: 41,206,518 (GRCm39) V185E probably benign Het
Gtf3a C A 5: 146,892,199 (GRCm39) R317S probably damaging Het
Ice2 A G 9: 69,319,510 (GRCm39) I320V probably benign Het
Jag1 A G 2: 136,957,538 (GRCm39) V58A probably benign Het
Macf1 T C 4: 123,293,184 (GRCm39) E1241G probably benign Het
Mogat2 T A 7: 98,872,339 (GRCm39) I171F probably benign Het
Muc6 G A 7: 141,223,981 (GRCm39) probably benign Het
Myo1c A T 11: 75,549,520 (GRCm39) Y201F probably benign Het
Myo9b A G 8: 71,796,806 (GRCm39) I884V probably damaging Het
Nudt9 T C 5: 104,209,541 (GRCm39) I264T possibly damaging Het
Or8g30 A G 9: 39,229,974 (GRCm39) V312A probably benign Het
Pdcd11 AGAGGAGGAGGAGGAGGAGGAGGAG AGAGGAGGAGGAGGAGGAGGAG 19: 47,101,876 (GRCm39) probably benign Het
Rabgef1 T C 5: 130,219,831 (GRCm39) V98A probably damaging Het
Raly A G 2: 154,707,841 (GRCm39) D287G probably damaging Het
Raph1 A G 1: 60,565,136 (GRCm39) V117A probably benign Het
Slc34a2 T C 5: 53,226,968 (GRCm39) F697S possibly damaging Het
Son T A 16: 91,453,761 (GRCm39) M836K probably damaging Het
Spock1 T C 13: 57,588,290 (GRCm39) M258V possibly damaging Het
Stk10 G T 11: 32,567,859 (GRCm39) C887F probably damaging Het
Synpo2 A G 3: 122,907,442 (GRCm39) S625P probably benign Het
Synrg T A 11: 83,900,258 (GRCm39) D821E probably damaging Het
Tafa5 T C 15: 87,604,691 (GRCm39) probably benign Het
Tg C A 15: 66,570,295 (GRCm39) A1389E possibly damaging Het
Tspan33 G A 6: 29,713,477 (GRCm39) V134M probably damaging Het
Ubr4 T C 4: 139,158,960 (GRCm39) F2438L probably benign Het
Vmn1r63 C T 7: 5,805,741 (GRCm39) W297* probably null Het
Vmn2r92 C T 17: 18,388,219 (GRCm39) A408V probably damaging Het
Zic5 A G 14: 122,697,073 (GRCm39) I514T unknown Het
Other mutations in Vmn1r210
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00938:Vmn1r210 APN 13 23,011,538 (GRCm39) nonsense probably null
IGL01541:Vmn1r210 APN 13 23,011,778 (GRCm39) missense probably benign
IGL01610:Vmn1r210 APN 13 23,011,977 (GRCm39) missense probably damaging 1.00
IGL01632:Vmn1r210 APN 13 23,011,366 (GRCm39) makesense probably null
IGL03268:Vmn1r210 APN 13 23,011,405 (GRCm39) missense probably benign 0.40
IGL03340:Vmn1r210 APN 13 23,011,644 (GRCm39) missense probably benign 0.23
R0629:Vmn1r210 UTSW 13 23,012,044 (GRCm39) missense probably damaging 1.00
R3792:Vmn1r210 UTSW 13 23,011,573 (GRCm39) missense probably damaging 1.00
R4125:Vmn1r210 UTSW 13 23,011,779 (GRCm39) missense probably benign 0.00
R4132:Vmn1r210 UTSW 13 23,011,819 (GRCm39) missense probably benign 0.00
R4773:Vmn1r210 UTSW 13 23,011,374 (GRCm39) missense probably benign 0.00
R5653:Vmn1r210 UTSW 13 23,011,378 (GRCm39) nonsense probably null
R6128:Vmn1r210 UTSW 13 23,012,277 (GRCm39) nonsense probably null
R6452:Vmn1r210 UTSW 13 23,011,840 (GRCm39) missense probably damaging 1.00
R6501:Vmn1r210 UTSW 13 23,011,705 (GRCm39) missense possibly damaging 0.90
R6864:Vmn1r210 UTSW 13 23,011,713 (GRCm39) missense probably benign 0.06
R7623:Vmn1r210 UTSW 13 23,011,405 (GRCm39) missense probably benign 0.40
R7991:Vmn1r210 UTSW 13 23,011,684 (GRCm39) missense probably benign 0.01
R9244:Vmn1r210 UTSW 13 23,012,089 (GRCm39) missense probably benign 0.02
R9439:Vmn1r210 UTSW 13 23,011,397 (GRCm39) missense possibly damaging 0.66
R9538:Vmn1r210 UTSW 13 23,011,837 (GRCm39) nonsense probably null
R9732:Vmn1r210 UTSW 13 23,011,379 (GRCm39) missense possibly damaging 0.75
R9794:Vmn1r210 UTSW 13 23,011,432 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- AGAAGCCCATCCCTGTGAATCAGC -3'
(R):5'- AAGTCTGCATGGCACATCCTTCC -3'

Sequencing Primer
(F):5'- TCCCTGTGAATCAGCACAAAGG -3'
(R):5'- TCTCATGGTCCTGAGAGATGC -3'
Posted On 2013-05-09