Incidental Mutation 'IGL02945:Tmem255b'
ID 364696
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmem255b
Ensembl Gene ENSMUSG00000038457
Gene Name transmembrane protein 255B
Synonyms Fam70b, LOC272465
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # IGL02945
Quality Score
Status
Chromosome 8
Chromosomal Location 13485189-13518473 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 13505141 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 149 (S149P)
Ref Sequence ENSEMBL: ENSMUSP00000130504 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000167071] [ENSMUST00000167505] [ENSMUST00000210804]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000167071
AA Change: S128P

PolyPhen 2 Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000127421
Gene: ENSMUSG00000038457
AA Change: S128P

DomainStartEndE-ValueType
Pfam:FAM70 1 68 8.2e-28 PFAM
Pfam:FAM70 66 307 1.8e-119 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000167505
AA Change: S149P

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000130504
Gene: ENSMUSG00000038457
AA Change: S149P

DomainStartEndE-ValueType
Pfam:FAM70 6 328 6e-166 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209950
Predicted Effect probably benign
Transcript: ENSMUST00000210804
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211356
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933411G06Rik A T 10: 51,633,095 (GRCm39) noncoding transcript Het
Adgrf4 T C 17: 42,978,257 (GRCm39) Q362R probably benign Het
Akap6 A G 12: 52,927,620 (GRCm39) N177D probably damaging Het
Alms1 A G 6: 85,597,915 (GRCm39) I914V probably damaging Het
Arhgap11a A T 2: 113,667,818 (GRCm39) S394R possibly damaging Het
Cacna1h C T 17: 25,607,033 (GRCm39) V962I probably damaging Het
Calr3 A T 8: 73,192,401 (GRCm39) L91Q probably damaging Het
Ccnf T C 17: 24,443,890 (GRCm39) E626G probably damaging Het
Clec10a A T 11: 70,061,368 (GRCm39) I295F possibly damaging Het
Cop1 A T 1: 159,134,259 (GRCm39) N167I probably benign Het
Csmd1 G T 8: 16,321,584 (GRCm39) Q505K possibly damaging Het
Ctrc A C 4: 141,573,563 (GRCm39) V6G possibly damaging Het
Cyp2c69 T C 19: 39,875,091 (GRCm39) R21G possibly damaging Het
Dnah5 A G 15: 28,270,572 (GRCm39) H958R probably benign Het
Egfr T A 11: 16,702,514 (GRCm39) L11Q probably damaging Het
Erich2 A G 2: 70,364,738 (GRCm39) T371A probably damaging Het
Fbxl21 T A 13: 56,674,983 (GRCm39) F111L probably damaging Het
Grik4 G T 9: 42,509,175 (GRCm39) T416N possibly damaging Het
Grin3a A G 4: 49,792,971 (GRCm39) V254A possibly damaging Het
Hat1 G A 2: 71,251,037 (GRCm39) R195K probably benign Het
Hmgb4 A C 4: 128,154,387 (GRCm39) Y60* probably null Het
Ighv12-3 A G 12: 114,330,337 (GRCm39) W53R probably damaging Het
Irs2 C A 8: 11,057,781 (GRCm39) C217F probably damaging Het
Kcnb1 T C 2: 167,030,308 (GRCm39) E79G probably benign Het
Lingo3 A G 10: 80,670,532 (GRCm39) I466T probably damaging Het
Lyst T C 13: 13,935,783 (GRCm39) S3665P possibly damaging Het
Myh9 A T 15: 77,646,205 (GRCm39) L1926Q probably benign Het
Myom1 A G 17: 71,399,088 (GRCm39) probably benign Het
Nbeal1 T C 1: 60,245,569 (GRCm39) F198L probably damaging Het
Nktr A G 9: 121,557,697 (GRCm39) T63A probably damaging Het
Nle1 A T 11: 82,794,910 (GRCm39) probably benign Het
Nr3c2 A T 8: 77,636,288 (GRCm39) D463V probably damaging Het
Or5k17 A T 16: 58,746,703 (GRCm39) I77N probably damaging Het
Or8b43 A G 9: 38,360,812 (GRCm39) I215V probably benign Het
Pcdhb18 T C 18: 37,623,048 (GRCm39) I126T probably benign Het
Pgm1 A G 4: 99,818,731 (GRCm39) I127V probably benign Het
Rai14 A G 15: 10,574,795 (GRCm39) I721T probably benign Het
Rps6ka1 A G 4: 133,594,510 (GRCm39) Y57H probably damaging Het
Scara3 T A 14: 66,168,660 (GRCm39) D319V probably damaging Het
Selp G A 1: 163,961,498 (GRCm39) G404S probably damaging Het
Serinc3 A G 2: 163,472,836 (GRCm39) probably benign Het
Slc4a8 A G 15: 100,705,080 (GRCm39) probably null Het
Spen G T 4: 141,221,624 (GRCm39) L325I unknown Het
Sphkap A T 1: 83,254,552 (GRCm39) S779T probably damaging Het
Stxbp2 A T 8: 3,691,971 (GRCm39) I538F probably benign Het
Thumpd1 A T 7: 119,315,970 (GRCm39) S326R possibly damaging Het
Tnni3k A T 3: 154,743,075 (GRCm39) S95T possibly damaging Het
Trim66 G A 7: 109,059,383 (GRCm39) Q954* probably null Het
Ttn A T 2: 76,582,316 (GRCm39) I22859N probably damaging Het
Zfp319 A T 8: 96,050,446 (GRCm39) probably benign Het
Other mutations in Tmem255b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00823:Tmem255b APN 8 13,507,054 (GRCm39) missense probably benign
IGL02635:Tmem255b APN 8 13,505,195 (GRCm39) missense probably damaging 1.00
IGL02679:Tmem255b APN 8 13,507,055 (GRCm39) missense probably benign 0.04
IGL03007:Tmem255b APN 8 13,507,066 (GRCm39) missense possibly damaging 0.94
IGL03146:Tmem255b APN 8 13,504,174 (GRCm39) missense probably damaging 1.00
R2278:Tmem255b UTSW 8 13,501,081 (GRCm39) missense probably damaging 1.00
R2410:Tmem255b UTSW 8 13,491,278 (GRCm39) missense probably benign 0.22
R3081:Tmem255b UTSW 8 13,501,048 (GRCm39) missense probably damaging 0.99
R4498:Tmem255b UTSW 8 13,505,998 (GRCm39) missense probably damaging 1.00
R4612:Tmem255b UTSW 8 13,504,228 (GRCm39) missense probably benign 0.00
R6018:Tmem255b UTSW 8 13,505,138 (GRCm39) missense probably benign 0.00
R6073:Tmem255b UTSW 8 13,506,958 (GRCm39) missense probably damaging 0.98
R6240:Tmem255b UTSW 8 13,504,216 (GRCm39) missense probably damaging 1.00
R6737:Tmem255b UTSW 8 13,507,096 (GRCm39) critical splice donor site probably null
R8231:Tmem255b UTSW 8 13,504,225 (GRCm39) missense probably damaging 0.97
R9653:Tmem255b UTSW 8 13,506,005 (GRCm39) missense probably damaging 1.00
Posted On 2015-12-18