Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02965:Kif18b'

365562

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Kif18b

Ensembl Gene

ENSMUSG00000051378

Gene Name

kinesin family member 18B

Synonyms

N-8 kinesin, 3000004C01Rik

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL02965

Quality Score

Status

Chromosome

Chromosomal Location

102796355-102815950 bp(-) (GRCm39)

Type of Mutation

start gained

DNA Base Change (assembly)

A to G at 102807338 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000021311 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000021311]

AlphaFold

Q6PFD6

Predicted Effect

probably benign
Transcript: ENSMUST00000021311

SMART Domains

Protein: ENSMUSP00000021311
Gene: ENSMUSG00000051378

Domain	Start	End	E-Value	Type
KISc	7	361	1.47e-158	SMART
coiled coil region	368	404	N/A	INTRINSIC
low complexity region	510	522	N/A	INTRINSIC
low complexity region	676	682	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000132502

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000181125

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca6	T	C	11: 110,071,439 (GRCm39)	K1471R	probably benign	Het
Add1	A	G	5: 34,777,467 (GRCm39)	S77G	probably damaging	Het
Atm	G	T	9: 53,364,863 (GRCm39)	N2642K	probably damaging	Het
Atp6v0a2	T	A	5: 124,767,267 (GRCm39)	M10K	possibly damaging	Het
Btd	T	A	14: 31,389,193 (GRCm39)	S305T	probably damaging	Het
Cmya5	C	T	13: 93,229,065 (GRCm39)	V2008I	probably benign	Het
Cpd	T	G	11: 76,681,814 (GRCm39)		probably benign	Het
Dis3l	A	G	9: 64,217,766 (GRCm39)	F772L	probably damaging	Het
Dlg5	A	T	14: 24,222,091 (GRCm39)	I517N	probably damaging	Het
Fig4	G	A	10: 41,161,661 (GRCm39)	T34M	probably damaging	Het
Flna	C	T	X: 73,270,816 (GRCm39)	V2235I	probably damaging	Het
Flot2	T	C	11: 77,950,031 (GRCm39)	I371T	possibly damaging	Het
Fsip2	G	A	2: 82,813,398 (GRCm39)	S3239N	probably benign	Het
Gbp3	A	G	3: 142,273,343 (GRCm39)	I297V	probably benign	Het
Gcnt3	T	C	9: 69,942,235 (GRCm39)	E111G	probably benign	Het
Gdi1	G	T	X: 73,351,331 (GRCm39)	A148S	probably benign	Het
Heatr5b	G	A	17: 79,060,502 (GRCm39)	H2058Y	probably benign	Het
Hsp90aa1	A	G	12: 110,662,113 (GRCm39)	M1T	probably null	Het
Il22b	A	G	10: 118,130,762 (GRCm39)	S45P	probably damaging	Het
Inppl1	C	A	7: 101,477,478 (GRCm39)	V715F	possibly damaging	Het
Kansl1	T	C	11: 104,225,991 (GRCm39)	Y975C	probably damaging	Het
Krt40	T	A	11: 99,432,492 (GRCm39)	R175W	probably damaging	Het
Map3k19	T	C	1: 127,751,803 (GRCm39)	D516G	probably damaging	Het
Mfsd3	A	G	15: 76,587,352 (GRCm39)	H345R	probably benign	Het
Mlkl	A	T	8: 112,058,469 (GRCm39)	I162N	probably benign	Het
Mtnr1a	A	T	8: 45,522,419 (GRCm39)	N58I	probably damaging	Het
Nsmf	T	C	2: 24,951,774 (GRCm39)	V499A	probably damaging	Het
Nudt6	A	G	3: 37,473,655 (GRCm39)	L22P	probably damaging	Het
Nxf7	T	G	X: 134,490,159 (GRCm39)	E35A	probably damaging	Het
Or11h23	A	C	14: 50,948,653 (GRCm39)	I289L	probably damaging	Het
Paf1	T	C	7: 28,095,629 (GRCm39)		probably null	Het
Pcdhb11	G	T	18: 37,557,021 (GRCm39)	V784L	probably benign	Het
Pglyrp2	T	C	17: 32,637,560 (GRCm39)	D156G	probably benign	Het
Pnpt1	A	G	11: 29,106,939 (GRCm39)	D670G	probably damaging	Het
Polr1b	T	A	2: 128,967,443 (GRCm39)	H945Q	probably benign	Het
Ptk6	C	T	2: 180,840,861 (GRCm39)		probably benign	Het
Rftn1	C	T	17: 50,362,280 (GRCm39)	E273K	probably benign	Het
Rnf125	A	G	18: 21,116,168 (GRCm39)	I117V	probably benign	Het
Robo4	A	G	9: 37,321,765 (GRCm39)	K742R	possibly damaging	Het
Sez6l	T	C	5: 112,623,440 (GRCm39)	E37G	probably damaging	Het
Skint4	A	T	4: 111,993,218 (GRCm39)	I306L	probably benign	Het
Sntb1	A	T	15: 55,506,081 (GRCm39)	Y497*	probably null	Het
Snx27	C	A	3: 94,489,733 (GRCm39)	V42L	probably damaging	Het
Sorbs1	T	A	19: 40,365,187 (GRCm39)	T199S	probably benign	Het
Sorcs2	A	G	5: 36,235,301 (GRCm39)	Y72H	probably benign	Het
Spef2	G	T	15: 9,725,192 (GRCm39)		probably benign	Het
Sucla2	G	T	14: 73,816,871 (GRCm39)	V204L	probably benign	Het
Tescl	C	A	7: 24,033,098 (GRCm39)	V76F	probably damaging	Het
Tnxb	T	A	17: 34,928,628 (GRCm39)	Y2681N	possibly damaging	Het
Usp42	T	C	5: 143,713,769 (GRCm39)	T2A	probably damaging	Het
Vdac3-ps1	T	A	13: 18,205,431 (GRCm39)		noncoding transcript	Het
Wapl	T	A	14: 34,461,181 (GRCm39)		probably benign	Het

Other mutations in Kif18b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00966:Kif18b	APN	11	102,805,501 (GRCm39)	missense	probably damaging	0.99
IGL01570:Kif18b	APN	11	102,803,217 (GRCm39)	missense	probably benign	0.04
IGL02997:Kif18b	APN	11	102,799,910 (GRCm39)	missense	probably damaging	1.00
IGL03135:Kif18b	APN	11	102,805,086 (GRCm39)	missense	probably damaging	1.00
IGL02988:Kif18b	UTSW	11	102,799,146 (GRCm39)	missense	probably damaging	1.00
R0541:Kif18b	UTSW	11	102,806,001 (GRCm39)	missense	probably damaging	0.98
R1446:Kif18b	UTSW	11	102,805,525 (GRCm39)	missense	probably damaging	0.99
R1674:Kif18b	UTSW	11	102,803,886 (GRCm39)	missense	probably benign	0.04
R1729:Kif18b	UTSW	11	102,806,367 (GRCm39)	critical splice donor site	probably null
R1784:Kif18b	UTSW	11	102,806,367 (GRCm39)	critical splice donor site	probably null
R2249:Kif18b	UTSW	11	102,803,214 (GRCm39)	missense	probably benign	0.01
R2291:Kif18b	UTSW	11	102,799,096 (GRCm39)	missense	probably damaging	1.00
R3723:Kif18b	UTSW	11	102,807,102 (GRCm39)	missense	probably damaging	1.00
R5496:Kif18b	UTSW	11	102,804,568 (GRCm39)	missense	possibly damaging	0.88
R5500:Kif18b	UTSW	11	102,806,526 (GRCm39)	missense	probably damaging	1.00
R5598:Kif18b	UTSW	11	102,799,015 (GRCm39)	missense	possibly damaging	0.89
R5820:Kif18b	UTSW	11	102,803,874 (GRCm39)	missense	probably benign	0.00
R5910:Kif18b	UTSW	11	102,804,370 (GRCm39)	missense	probably benign
R5912:Kif18b	UTSW	11	102,803,817 (GRCm39)	missense	probably benign
R6394:Kif18b	UTSW	11	102,805,236 (GRCm39)	missense	probably damaging	1.00
R6541:Kif18b	UTSW	11	102,805,092 (GRCm39)	missense	probably damaging	1.00
R6911:Kif18b	UTSW	11	102,807,206 (GRCm39)	missense	probably damaging	0.96
R7467:Kif18b	UTSW	11	102,803,174 (GRCm39)	splice site	probably null
R7467:Kif18b	UTSW	11	102,807,234 (GRCm39)	missense	probably damaging	1.00
R7526:Kif18b	UTSW	11	102,805,493 (GRCm39)	missense	probably damaging	1.00
R7581:Kif18b	UTSW	11	102,805,548 (GRCm39)	missense	probably damaging	1.00
R8314:Kif18b	UTSW	11	102,803,900 (GRCm39)	missense	probably benign
R8378:Kif18b	UTSW	11	102,807,299 (GRCm39)	missense	probably damaging	1.00
RF013:Kif18b	UTSW	11	102,803,192 (GRCm39)	missense	probably benign	0.00
Z1088:Kif18b	UTSW	11	102,798,983 (GRCm39)	missense	probably benign

Posted On

2015-12-18