Incidental Mutation 'IGL03128:Igkv4-70'
ID410206
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Igkv4-70
Ensembl Gene ENSMUSG00000076547
Gene Nameimmunoglobulin kappa chain variable 4-70
SynonymsGm1502, LOC385120
Accession Numbers
Is this an essential gene? Not available question?
Stock #IGL03128
Quality Score
Status
Chromosome6
Chromosomal Location69267888-69268412 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 69268014 bp
ZygosityHeterozygous
Amino Acid Change Lysine to Asparagine at position 74 (K74N)
Ref Sequence ENSEMBL: ENSMUSP00000100149 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103348]
Predicted Effect probably benign
Transcript: ENSMUST00000103348
AA Change: K74N

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000100149
Gene: ENSMUSG00000076547
AA Change: K74N

DomainStartEndE-ValueType
IGv 40 111 6.19e-18 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acox1 A T 11: 116,182,003 L114M probably damaging Het
Bahcc1 G A 11: 120,268,434 probably benign Het
Btrc T A 19: 45,513,520 I226N probably damaging Het
Cth C T 3: 157,921,035 G56D probably damaging Het
Dkk2 T C 3: 132,177,860 probably benign Het
Dock3 A T 9: 107,032,292 M271K probably benign Het
Fam78b T A 1: 167,078,941 L223Q probably damaging Het
Fgl2 A T 5: 21,373,293 M193L probably benign Het
Ifi205 A T 1: 174,015,086 V348E probably damaging Het
Kdm3b A T 18: 34,827,427 K1355M probably damaging Het
Ltn1 A T 16: 87,415,944 N576K probably benign Het
Ms4a4c A T 19: 11,417,641 probably null Het
Nfic T C 10: 81,406,191 T328A probably benign Het
Npat T A 9: 53,550,033 probably benign Het
Nxpe2 T C 9: 48,319,498 I524V probably benign Het
Orc5 G T 5: 22,516,773 D360E probably damaging Het
Pappa2 C T 1: 158,936,484 E486K probably benign Het
Pde9a C T 17: 31,459,910 H216Y possibly damaging Het
Polr2k C A 15: 36,174,191 P31Q probably damaging Het
Prkdc G T 16: 15,700,744 probably benign Het
Raver1 A T 9: 21,080,742 L385Q probably damaging Het
Slc10a7 C A 8: 78,525,217 T80K probably damaging Het
Smg1 T C 7: 118,203,059 K272R probably benign Het
Supt20 A G 3: 54,708,287 I200V probably benign Het
Tbc1d9 A G 8: 83,166,085 N4S probably benign Het
Tor1aip1 A G 1: 156,007,035 S356P probably damaging Het
Trpm3 A G 19: 22,914,465 Y903C probably damaging Het
Vmn2r71 T G 7: 85,619,587 F333V probably damaging Het
Other mutations in Igkv4-70
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00549:Igkv4-70 APN 6 69268091 missense probably damaging 0.98
IGL02047:Igkv4-70 APN 6 69267927 missense probably damaging 0.99
R5139:Igkv4-70 UTSW 6 69268105 missense probably damaging 0.99
R6736:Igkv4-70 UTSW 6 69267928 missense probably damaging 1.00
Posted On2016-08-02