Incidental Mutation 'IGL03141:Decr1'
ID 410695
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Decr1
Ensembl Gene ENSMUSG00000028223
Gene Name 2,4-dienoyl CoA reductase 1, mitochondrial
Synonyms 1200012F07Rik, Nadph, Decr
Accession Numbers
Essential gene? Possibly essential (E-score: 0.628) question?
Stock # IGL03141
Quality Score
Status
Chromosome 4
Chromosomal Location 15917240-15945377 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 15932902 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Lysine at position 88 (I88K)
Ref Sequence ENSEMBL: ENSMUSP00000029877 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029877]
AlphaFold Q9CQ62
Predicted Effect probably damaging
Transcript: ENSMUST00000029877
AA Change: I88K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000029877
Gene: ENSMUSG00000028223
AA Change: I88K

DomainStartEndE-ValueType
Pfam:adh_short 60 253 7.7e-34 PFAM
Pfam:KR 61 182 4.3e-9 PFAM
Pfam:adh_short_C2 66 304 2e-27 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150464
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an accessory enzyme which participates in the beta-oxidation and metabolism of unsaturated fatty enoyl-CoA esters. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit increased sensitivity to fasting and cold stresses. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 20 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adm2 T C 15: 89,207,531 (GRCm39) I14T probably benign Het
AY761185 G A 8: 21,434,576 (GRCm39) R51C possibly damaging Het
Cenpt T A 8: 106,578,573 (GRCm39) T15S probably damaging Het
Cotl1 T C 8: 120,537,022 (GRCm39) K131E possibly damaging Het
D5Ertd579e T A 5: 36,770,621 (GRCm39) D1258V possibly damaging Het
Efcab3 T C 11: 104,986,696 (GRCm39) S5408P probably damaging Het
Gsto2 T C 19: 47,863,312 (GRCm39) Y63H probably damaging Het
Lrp2 A T 2: 69,307,370 (GRCm39) D2896E probably damaging Het
Lrrc3b T G 14: 15,358,390 (GRCm38) D72A probably damaging Het
Npas1 T C 7: 16,199,063 (GRCm39) E164G probably damaging Het
Or6f1 T A 7: 85,970,909 (GRCm39) I84F probably damaging Het
Parp14 C A 16: 35,659,663 (GRCm39) R1653L probably benign Het
Polq A G 16: 36,837,720 (GRCm39) probably benign Het
Sec31b A T 19: 44,514,759 (GRCm39) probably benign Het
Slc7a11 C T 3: 50,336,334 (GRCm39) A337T possibly damaging Het
Snapc3 A G 4: 83,353,523 (GRCm39) I187M probably damaging Het
Sorcs2 T C 5: 36,222,699 (GRCm39) E352G probably benign Het
Spout1 A C 2: 30,065,067 (GRCm39) V311G probably damaging Het
Syne1 T A 10: 5,374,261 (GRCm39) K182M probably damaging Het
Vmn2r110 A G 17: 20,803,976 (GRCm39) S200P possibly damaging Het
Other mutations in Decr1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00718:Decr1 APN 4 15,933,056 (GRCm39) missense probably benign 0.23
IGL02736:Decr1 APN 4 15,930,952 (GRCm39) missense probably benign 0.01
I1329:Decr1 UTSW 4 15,930,976 (GRCm39) nonsense probably null
R0472:Decr1 UTSW 4 15,919,849 (GRCm39) missense probably damaging 1.00
R1295:Decr1 UTSW 4 15,919,207 (GRCm39) missense possibly damaging 0.93
R1898:Decr1 UTSW 4 15,929,801 (GRCm39) missense probably damaging 1.00
R1955:Decr1 UTSW 4 15,924,256 (GRCm39) missense probably benign 0.09
R3160:Decr1 UTSW 4 15,930,972 (GRCm39) missense probably damaging 0.99
R3162:Decr1 UTSW 4 15,930,972 (GRCm39) missense probably damaging 0.99
R3162:Decr1 UTSW 4 15,930,972 (GRCm39) missense probably damaging 0.99
R4545:Decr1 UTSW 4 15,930,979 (GRCm39) missense probably damaging 1.00
R4962:Decr1 UTSW 4 15,930,976 (GRCm39) nonsense probably null
R5188:Decr1 UTSW 4 15,924,270 (GRCm39) missense probably damaging 1.00
R5190:Decr1 UTSW 4 15,924,270 (GRCm39) missense probably damaging 1.00
R5215:Decr1 UTSW 4 15,929,795 (GRCm39) missense probably damaging 1.00
R5556:Decr1 UTSW 4 15,919,244 (GRCm39) missense probably damaging 1.00
R6164:Decr1 UTSW 4 15,924,347 (GRCm39) missense probably benign 0.32
R6253:Decr1 UTSW 4 15,931,179 (GRCm39) missense probably benign 0.00
R6313:Decr1 UTSW 4 15,924,261 (GRCm39) missense probably benign 0.00
R6830:Decr1 UTSW 4 15,924,355 (GRCm39) critical splice acceptor site probably null
R6998:Decr1 UTSW 4 15,930,960 (GRCm39) missense probably damaging 1.00
R7064:Decr1 UTSW 4 15,945,392 (GRCm39)
R8052:Decr1 UTSW 4 15,933,019 (GRCm39) missense probably benign 0.00
R8698:Decr1 UTSW 4 15,922,483 (GRCm39) critical splice donor site probably null
R8806:Decr1 UTSW 4 15,945,351 (GRCm39) start codon destroyed probably benign 0.01
R9217:Decr1 UTSW 4 15,930,969 (GRCm39) missense probably damaging 1.00
X0026:Decr1 UTSW 4 15,919,846 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02