Incidental Mutation 'IGL03274:Krt20'
ID415368
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Krt20
Ensembl Gene ENSMUSG00000035775
Gene Namekeratin 20
SynonymsCK20, 9030623C06Rik, cytokeratin 20
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.077) question?
Stock #IGL03274
Quality Score
Status
Chromosome11
Chromosomal Location99428403-99438150 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) A to T at 99430029 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000017743 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000017743]
Predicted Effect probably benign
Transcript: ENSMUST00000017743
SMART Domains Protein: ENSMUSP00000017743
Gene: ENSMUSG00000035775

DomainStartEndE-ValueType
low complexity region 3 26 N/A INTRINSIC
Filament 76 387 7.19e-146 SMART
low complexity region 410 431 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128904
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a member of the keratin protein family and is found within a cluster of cytokeratin genes on chromosome 11. Keratins are cytoskeletal proteins that are preferentially expressed in epithelial cells. The encoded protein may help maintain intermediate filament organization in intestinal epithelium. Phosphorylation of this protein may also influence mucin secretion in the small intestine. [provided by RefSeq, Dec 2015]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700037H04Rik A T 2: 131,153,592 probably null Het
Anln C A 9: 22,382,269 R26M probably damaging Het
Capn15 A T 17: 25,961,838 S753T probably damaging Het
Ccdc62 A G 5: 123,954,680 N576S probably benign Het
Csmd3 T C 15: 47,645,504 D2895G probably damaging Het
Dspp T A 5: 104,174,948 V37E probably damaging Het
Efcab6 T C 15: 83,868,249 D1473G probably damaging Het
Ehhadh T C 16: 21,763,340 probably benign Het
Fbln1 T C 15: 85,232,678 probably null Het
Gbp9 A G 5: 105,082,786 V424A possibly damaging Het
Gda T C 19: 21,417,007 Y236C possibly damaging Het
Gm11639 A T 11: 104,721,093 D587V probably benign Het
Gm4884 A G 7: 41,044,545 E646G probably damaging Het
Gm4952 C A 19: 12,623,596 probably benign Het
Gm5422 G T 10: 31,250,352 noncoding transcript Het
Grin2b C T 6: 135,780,255 D403N possibly damaging Het
Hsf2bp G A 17: 32,007,770 R204C probably damaging Het
Il16 T C 7: 83,661,234 E488G probably damaging Het
Kat6b G T 14: 21,609,763 D212Y possibly damaging Het
Kctd2 A C 11: 115,429,382 I247L possibly damaging Het
Kel T A 6: 41,687,995 probably null Het
Litaf T C 16: 10,966,569 T26A probably damaging Het
N4bp2l2 G T 5: 150,661,466 Q350K probably damaging Het
Nav2 T G 7: 49,362,099 I26S probably damaging Het
Nfya A G 17: 48,391,347 Y162H probably damaging Het
Olfr117 C T 17: 37,659,755 A193T probably benign Het
Pbx4 A T 8: 69,866,550 S244C probably damaging Het
Pcdhb16 T C 18: 37,479,232 V415A probably benign Het
Rbbp8 A G 18: 11,741,076 probably benign Het
Sp100 T C 1: 85,707,304 probably benign Het
Spag16 A G 1: 69,844,381 probably benign Het
Star A G 8: 25,811,054 D138G possibly damaging Het
Other mutations in Krt20
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01455:Krt20 APN 11 99431943 missense probably benign 0.01
IGL01926:Krt20 APN 11 99437826 missense probably damaging 1.00
IGL02105:Krt20 APN 11 99438001 missense probably benign 0.01
IGL03225:Krt20 APN 11 99431930 missense probably damaging 0.97
IGL03331:Krt20 APN 11 99435430 splice site probably null
R0091:Krt20 UTSW 11 99437814 missense probably damaging 1.00
R0446:Krt20 UTSW 11 99437776 nonsense probably null
R3955:Krt20 UTSW 11 99432211 nonsense probably null
R4805:Krt20 UTSW 11 99428985 missense unknown
R5156:Krt20 UTSW 11 99430053 missense possibly damaging 0.92
R5620:Krt20 UTSW 11 99435457 missense probably damaging 1.00
R6716:Krt20 UTSW 11 99431928 missense possibly damaging 0.77
R7006:Krt20 UTSW 11 99437761 missense probably benign 0.34
Posted On2016-08-02