Incidental Mutation 'IGL03300:Or4c10'
ID 416198
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or4c10
Ensembl Gene ENSMUSG00000049149
Gene Name olfactory receptor family 4 subfamily C member 10
Synonyms GA_x6K02T2Q125-51361752-51362687, MOR232-3, Olfr1258
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # IGL03300
Quality Score
Status
Chromosome 2
Chromosomal Location 89752288-89761090 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 89760571 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 139 (C139*)
Ref Sequence ENSEMBL: ENSMUSP00000149547 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102609] [ENSMUST00000111516] [ENSMUST00000213720]
AlphaFold Q8VGN6
Predicted Effect probably null
Transcript: ENSMUST00000102609
AA Change: C139*
SMART Domains Protein: ENSMUSP00000099669
Gene: ENSMUSG00000049149
AA Change: C139*

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 2.6e-52 PFAM
Pfam:7TM_GPCR_Srsx 33 299 3.4e-5 PFAM
Pfam:7tm_1 39 285 6.4e-20 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000111516
AA Change: C139*
SMART Domains Protein: ENSMUSP00000107141
Gene: ENSMUSG00000049149
AA Change: C139*

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 33 299 3.4e-5 PFAM
Pfam:7tm_1 39 285 4.9e-32 PFAM
Pfam:7tm_4 137 278 2.7e-43 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000213720
AA Change: C139*
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 8 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Lpar5 T C 6: 125,059,203 (GRCm39) L308P probably damaging Het
Mcm9 A G 10: 53,487,523 (GRCm39) S515P probably damaging Het
Or2d36 T C 7: 106,746,616 (GRCm39) F31S probably damaging Het
Pclo A G 5: 14,762,812 (GRCm39) M3762V unknown Het
Pgr G A 9: 8,961,540 (GRCm39) D871N probably damaging Het
Ppfibp1 A G 6: 146,931,825 (GRCm39) E957G probably damaging Het
Pus10 T C 11: 23,681,368 (GRCm39) probably benign Het
Slco1a8 A G 6: 141,940,532 (GRCm39) F110L probably damaging Het
Other mutations in Or4c10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02386:Or4c10 APN 2 89,760,888 (GRCm39) missense probably damaging 0.96
IGL02552:Or4c10 APN 2 89,760,903 (GRCm39) missense probably benign 0.01
R0081:Or4c10 UTSW 2 89,760,423 (GRCm39) missense possibly damaging 0.90
R0197:Or4c10 UTSW 2 89,760,545 (GRCm39) missense probably benign 0.00
R0701:Or4c10 UTSW 2 89,760,545 (GRCm39) missense probably benign 0.00
R0883:Or4c10 UTSW 2 89,760,545 (GRCm39) missense probably benign 0.00
R1163:Or4c10 UTSW 2 89,760,449 (GRCm39) missense possibly damaging 0.78
R1833:Or4c10 UTSW 2 89,760,645 (GRCm39) nonsense probably null
R1846:Or4c10 UTSW 2 89,761,010 (GRCm39) missense possibly damaging 0.45
R4504:Or4c10 UTSW 2 89,760,695 (GRCm39) missense possibly damaging 0.89
R4507:Or4c10 UTSW 2 89,760,695 (GRCm39) missense possibly damaging 0.89
R4679:Or4c10 UTSW 2 89,761,008 (GRCm39) missense possibly damaging 0.63
R4908:Or4c10 UTSW 2 89,760,923 (GRCm39) missense probably benign 0.00
R5430:Or4c10 UTSW 2 89,760,257 (GRCm39) missense probably benign 0.00
R6836:Or4c10 UTSW 2 89,760,683 (GRCm39) missense probably damaging 1.00
R7552:Or4c10 UTSW 2 89,761,064 (GRCm39) missense probably benign 0.06
R7709:Or4c10 UTSW 2 89,760,225 (GRCm39) missense probably benign 0.00
R8060:Or4c10 UTSW 2 89,760,693 (GRCm39) missense probably benign 0.04
R8349:Or4c10 UTSW 2 89,760,878 (GRCm39) missense possibly damaging 0.48
R8449:Or4c10 UTSW 2 89,760,878 (GRCm39) missense possibly damaging 0.48
Z1177:Or4c10 UTSW 2 89,760,942 (GRCm39) nonsense probably null
Posted On 2016-08-02