Incidental Mutation 'IGL03082:Slc35f1'
| ID |
417898 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Slc35f1
|
| Ensembl Gene |
ENSMUSG00000038602 |
| Gene Name |
solute carrier family 35, member F1 |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL03082
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
10 |
| Chromosomal Location |
52566629-52987718 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 52809234 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Isoleucine
at position 74
(V74I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000101113
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000105473]
|
| AlphaFold |
Q8BGK5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000105473
AA Change: V74I
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000101113
Gene: ENSMUSG00000038602
AA Change: V74I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
20 |
N/A |
INTRINSIC |
|
Pfam:SLC35F
|
56 |
355 |
1.4e-151 |
PFAM |
|
Pfam:CRT-like
|
66 |
315 |
2.3e-13 |
PFAM |
|
Pfam:EamA
|
217 |
355 |
1.7e-9 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit no detectable phenotypic abnormalities. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 37 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Asic1 |
T |
A |
15: 99,594,428 (GRCm39) |
N324K |
probably benign |
Het |
| Atpaf2 |
T |
C |
11: 60,294,670 (GRCm39) |
E251G |
probably damaging |
Het |
| Cacna1d |
T |
C |
14: 29,821,190 (GRCm39) |
K1109E |
probably damaging |
Het |
| Ces1d |
C |
A |
8: 93,896,346 (GRCm39) |
|
probably null |
Het |
| Chst1 |
C |
T |
2: 92,444,278 (GRCm39) |
T250I |
possibly damaging |
Het |
| Cpne6 |
T |
C |
14: 55,753,760 (GRCm39) |
L406P |
probably damaging |
Het |
| Cryz |
A |
G |
3: 154,310,563 (GRCm39) |
M8V |
probably damaging |
Het |
| Dpysl2 |
T |
C |
14: 67,045,459 (GRCm39) |
E438G |
probably damaging |
Het |
| Elovl1 |
T |
C |
4: 118,288,077 (GRCm39) |
I71T |
probably benign |
Het |
| Eml2 |
T |
A |
7: 18,935,802 (GRCm39) |
Y679N |
probably damaging |
Het |
| Fam185a |
G |
A |
5: 21,660,836 (GRCm39) |
V284I |
possibly damaging |
Het |
| Fpgs |
C |
T |
2: 32,575,769 (GRCm39) |
W391* |
probably null |
Het |
| Hdac11 |
C |
T |
6: 91,150,085 (GRCm39) |
P295S |
probably damaging |
Het |
| Herc2 |
A |
T |
7: 55,835,671 (GRCm39) |
I3260F |
probably benign |
Het |
| Hltf |
G |
A |
3: 20,118,723 (GRCm39) |
|
probably benign |
Het |
| Immp2l |
T |
G |
12: 41,160,900 (GRCm39) |
V66G |
possibly damaging |
Het |
| Lrrc4c |
T |
C |
2: 97,460,931 (GRCm39) |
I519T |
probably benign |
Het |
| Megf8 |
A |
G |
7: 25,029,661 (GRCm39) |
T402A |
probably benign |
Het |
| Mttp |
T |
G |
3: 137,829,556 (GRCm39) |
I111L |
probably benign |
Het |
| Mycbp2 |
T |
A |
14: 103,441,805 (GRCm39) |
I1987F |
probably benign |
Het |
| Ncr1 |
T |
A |
7: 4,344,241 (GRCm39) |
|
probably benign |
Het |
| Nedd4 |
G |
A |
9: 72,584,676 (GRCm39) |
|
probably null |
Het |
| Nherf4 |
A |
T |
9: 44,162,083 (GRCm39) |
S39T |
possibly damaging |
Het |
| Nnt |
A |
G |
13: 119,533,404 (GRCm39) |
F87S |
probably damaging |
Het |
| Nol6 |
A |
G |
4: 41,115,878 (GRCm39) |
|
probably benign |
Het |
| Pkhd1 |
A |
T |
1: 20,635,857 (GRCm39) |
I491N |
probably damaging |
Het |
| Plcxd2 |
T |
C |
16: 45,785,473 (GRCm39) |
I311V |
probably damaging |
Het |
| Pou2f3 |
C |
A |
9: 43,058,212 (GRCm39) |
|
probably null |
Het |
| Rgsl1 |
G |
A |
1: 153,675,693 (GRCm39) |
T836I |
possibly damaging |
Het |
| Rttn |
G |
A |
18: 89,002,072 (GRCm39) |
G328D |
probably damaging |
Het |
| Serpina11 |
T |
C |
12: 103,952,560 (GRCm39) |
E77G |
probably benign |
Het |
| Slc7a6 |
A |
G |
8: 106,919,854 (GRCm39) |
|
probably null |
Het |
| Smco2 |
A |
G |
6: 146,761,542 (GRCm39) |
T154A |
possibly damaging |
Het |
| Tcerg1 |
A |
G |
18: 42,706,422 (GRCm39) |
Y1033C |
probably damaging |
Het |
| Tmem87a |
A |
G |
2: 120,227,847 (GRCm39) |
F100S |
possibly damaging |
Het |
| Tssk4 |
T |
C |
14: 55,888,518 (GRCm39) |
F129S |
probably damaging |
Het |
| Wdr43 |
C |
T |
17: 71,945,336 (GRCm39) |
T315I |
probably damaging |
Het |
|
| Other mutations in Slc35f1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00434:Slc35f1
|
APN |
10 |
52,938,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01073:Slc35f1
|
APN |
10 |
52,898,056 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL01433:Slc35f1
|
APN |
10 |
52,949,542 (GRCm39) |
splice site |
probably benign |
|
|
IGL01566:Slc35f1
|
APN |
10 |
52,965,551 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02693:Slc35f1
|
APN |
10 |
52,809,224 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02870:Slc35f1
|
APN |
10 |
52,809,303 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R0884:Slc35f1
|
UTSW |
10 |
52,965,443 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1340:Slc35f1
|
UTSW |
10 |
52,965,550 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1781:Slc35f1
|
UTSW |
10 |
52,938,532 (GRCm39) |
splice site |
probably null |
|
|
R1813:Slc35f1
|
UTSW |
10 |
52,809,291 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1908:Slc35f1
|
UTSW |
10 |
52,898,000 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R2044:Slc35f1
|
UTSW |
10 |
52,965,443 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2518:Slc35f1
|
UTSW |
10 |
52,949,630 (GRCm39) |
missense |
probably benign |
0.07 |
|
R3872:Slc35f1
|
UTSW |
10 |
52,898,006 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R3934:Slc35f1
|
UTSW |
10 |
52,984,314 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3935:Slc35f1
|
UTSW |
10 |
52,984,314 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3936:Slc35f1
|
UTSW |
10 |
52,984,314 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4118:Slc35f1
|
UTSW |
10 |
52,965,464 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4921:Slc35f1
|
UTSW |
10 |
52,938,698 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5116:Slc35f1
|
UTSW |
10 |
52,897,991 (GRCm39) |
missense |
probably benign |
0.39 |
|
R5378:Slc35f1
|
UTSW |
10 |
52,567,157 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5387:Slc35f1
|
UTSW |
10 |
52,984,260 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5500:Slc35f1
|
UTSW |
10 |
52,809,318 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5590:Slc35f1
|
UTSW |
10 |
52,984,274 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R5743:Slc35f1
|
UTSW |
10 |
52,965,546 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5916:Slc35f1
|
UTSW |
10 |
52,809,317 (GRCm39) |
nonsense |
probably null |
|
|
R6985:Slc35f1
|
UTSW |
10 |
52,898,007 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7068:Slc35f1
|
UTSW |
10 |
52,938,596 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7295:Slc35f1
|
UTSW |
10 |
52,938,637 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7427:Slc35f1
|
UTSW |
10 |
52,965,510 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7428:Slc35f1
|
UTSW |
10 |
52,965,510 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8334:Slc35f1
|
UTSW |
10 |
52,984,244 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
| Posted On |
2016-08-02 |
Incidental Mutation