Incidental Mutation 'IGL03382:Zfp169'
| ID |
420731 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp169
|
| Ensembl Gene |
ENSMUSG00000050954 |
| Gene Name |
zinc finger protein 169 |
| Synonyms |
4930429A13Rik, 1700025J14Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.064)
|
| Stock # |
IGL03382
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
13 |
| Chromosomal Location |
48641123-48666927 bp(-) (GRCm39) |
| Type of Mutation |
unclassified |
| DNA Base Change (assembly) |
T to C
at 48644639 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000135520
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000110110]
[ENSMUST00000167682]
[ENSMUST00000176176]
[ENSMUST00000176949]
[ENSMUST00000176996]
[ENSMUST00000177530]
|
| AlphaFold |
E9Q3R6 |
| Predicted Effect |
unknown
Transcript: ENSMUST00000110110
AA Change: T163A
|
| SMART Domains |
Protein: ENSMUSP00000105737
Gene: ENSMUSG00000050954
AA Change: T163A
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
14 |
74 |
9.74e-36 |
SMART |
|
ZnF_C2H2
|
257 |
279 |
9.08e-4 |
SMART |
|
ZnF_C2H2
|
285 |
308 |
2.2e-2 |
SMART |
|
ZnF_C2H2
|
314 |
336 |
9.73e-4 |
SMART |
|
ZnF_C2H2
|
342 |
364 |
2.86e-1 |
SMART |
|
ZnF_C2H2
|
370 |
392 |
4.72e-2 |
SMART |
|
ZnF_C2H2
|
398 |
420 |
4.24e-4 |
SMART |
|
ZnF_C2H2
|
426 |
448 |
1.13e-4 |
SMART |
|
ZnF_C2H2
|
454 |
476 |
2.2e-2 |
SMART |
|
ZnF_C2H2
|
482 |
504 |
2.99e-4 |
SMART |
|
ZnF_C2H2
|
510 |
532 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
539 |
561 |
3.44e-4 |
SMART |
|
ZnF_C2H2
|
567 |
589 |
3.69e-4 |
SMART |
|
ZnF_C2H2
|
595 |
617 |
8.02e-5 |
SMART |
|
ZnF_C2H2
|
623 |
645 |
1.26e-2 |
SMART |
|
ZnF_C2H2
|
651 |
673 |
4.79e-3 |
SMART |
|
ZnF_C2H2
|
679 |
701 |
1.3e-4 |
SMART |
|
ZnF_C2H2
|
707 |
729 |
5.5e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000167682
|
| SMART Domains |
Protein: ENSMUSP00000127591
Gene: ENSMUSG00000050954
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
14 |
74 |
9.74e-36 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176176
|
| SMART Domains |
Protein: ENSMUSP00000134793
Gene: ENSMUSG00000050954
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
14 |
74 |
9.74e-36 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176949
|
| SMART Domains |
Protein: ENSMUSP00000135695
Gene: ENSMUSG00000050954
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
14 |
74 |
9.74e-36 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176996
|
| SMART Domains |
Protein: ENSMUSP00000135520
Gene: ENSMUSG00000050954
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
14 |
74 |
9.74e-36 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000177474
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000177530
AA Change: T163A
|
| SMART Domains |
Protein: ENSMUSP00000135414
Gene: ENSMUSG00000050954
AA Change: T163A
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
14 |
74 |
9.74e-36 |
SMART |
|
ZnF_C2H2
|
257 |
279 |
9.08e-4 |
SMART |
|
ZnF_C2H2
|
285 |
308 |
2.2e-2 |
SMART |
|
ZnF_C2H2
|
314 |
336 |
9.73e-4 |
SMART |
|
ZnF_C2H2
|
342 |
364 |
2.86e-1 |
SMART |
|
ZnF_C2H2
|
370 |
392 |
4.72e-2 |
SMART |
|
ZnF_C2H2
|
398 |
420 |
4.24e-4 |
SMART |
|
ZnF_C2H2
|
426 |
448 |
1.13e-4 |
SMART |
|
ZnF_C2H2
|
454 |
476 |
2.2e-2 |
SMART |
|
ZnF_C2H2
|
482 |
504 |
2.99e-4 |
SMART |
|
ZnF_C2H2
|
510 |
532 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
539 |
561 |
3.44e-4 |
SMART |
|
ZnF_C2H2
|
567 |
589 |
3.69e-4 |
SMART |
|
ZnF_C2H2
|
595 |
617 |
8.02e-5 |
SMART |
|
ZnF_C2H2
|
623 |
645 |
1.26e-2 |
SMART |
|
ZnF_C2H2
|
651 |
673 |
4.79e-3 |
SMART |
|
ZnF_C2H2
|
679 |
701 |
1.3e-4 |
SMART |
|
ZnF_C2H2
|
707 |
729 |
5.5e-3 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Homozygous disruption of this locus does not result in an overt phenotype early in life. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 42 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aff1 |
A |
G |
5: 103,988,926 (GRCm39) |
D831G |
possibly damaging |
Het |
| Amer2 |
A |
G |
14: 60,617,331 (GRCm39) |
K509E |
possibly damaging |
Het |
| Ankrd6 |
T |
C |
4: 32,808,771 (GRCm39) |
K449E |
probably damaging |
Het |
| Atp8b2 |
G |
A |
3: 89,855,828 (GRCm39) |
P459L |
probably benign |
Het |
| Atr |
C |
T |
9: 95,802,875 (GRCm39) |
R1846* |
probably null |
Het |
| Brd10 |
C |
T |
19: 29,694,676 (GRCm39) |
G1606R |
probably damaging |
Het |
| Ccdc159 |
C |
A |
9: 21,842,992 (GRCm39) |
|
probably null |
Het |
| Ccna1 |
A |
C |
3: 54,954,698 (GRCm39) |
Y338D |
probably damaging |
Het |
| Cpq |
A |
T |
15: 33,213,089 (GRCm39) |
E36V |
probably damaging |
Het |
| Cyp2c23 |
A |
G |
19: 44,003,371 (GRCm39) |
I268T |
probably damaging |
Het |
| Dctn2 |
G |
T |
10: 127,114,057 (GRCm39) |
Q332H |
probably damaging |
Het |
| Dnah17 |
T |
A |
11: 117,972,769 (GRCm39) |
I2055F |
probably damaging |
Het |
| Dnmt3b |
A |
G |
2: 153,528,279 (GRCm39) |
H764R |
probably damaging |
Het |
| Gphn |
T |
A |
12: 78,528,087 (GRCm39) |
I135K |
probably damaging |
Het |
| Hnrnpul1 |
A |
G |
7: 25,450,409 (GRCm39) |
M1T |
probably null |
Het |
| Htra4 |
T |
C |
8: 25,519,714 (GRCm39) |
D406G |
probably benign |
Het |
| Klk10 |
G |
T |
7: 43,433,883 (GRCm39) |
|
probably benign |
Het |
| Lilrb4a |
T |
A |
10: 51,367,616 (GRCm39) |
W53R |
probably benign |
Het |
| Magel2 |
T |
C |
7: 62,028,461 (GRCm39) |
V455A |
probably benign |
Het |
| Mrgprb5 |
T |
C |
7: 47,818,442 (GRCm39) |
T98A |
probably benign |
Het |
| Mrps35 |
T |
A |
6: 146,951,373 (GRCm39) |
C76* |
probably null |
Het |
| Myh7b |
C |
T |
2: 155,465,399 (GRCm39) |
R701C |
probably damaging |
Het |
| Nbeal1 |
G |
A |
1: 60,300,745 (GRCm39) |
|
probably null |
Het |
| Neb |
T |
A |
2: 52,215,720 (GRCm39) |
M196L |
probably benign |
Het |
| Nmd3 |
A |
G |
3: 69,642,421 (GRCm39) |
K207R |
probably damaging |
Het |
| Plxna4 |
C |
T |
6: 32,179,129 (GRCm39) |
R962Q |
probably benign |
Het |
| Pom121 |
T |
C |
5: 135,421,261 (GRCm39) |
K230E |
unknown |
Het |
| Psme4 |
A |
G |
11: 30,757,788 (GRCm39) |
D307G |
possibly damaging |
Het |
| Rnf41 |
T |
G |
10: 128,274,149 (GRCm39) |
M267R |
possibly damaging |
Het |
| Sis |
T |
C |
3: 72,836,052 (GRCm39) |
N846D |
probably benign |
Het |
| Slc22a19 |
T |
A |
19: 7,659,227 (GRCm39) |
I463L |
probably benign |
Het |
| Slc25a39 |
A |
T |
11: 102,297,030 (GRCm39) |
|
probably null |
Het |
| Slc35b2 |
C |
T |
17: 45,877,571 (GRCm39) |
R233C |
probably damaging |
Het |
| Slc4a4 |
T |
C |
5: 89,376,695 (GRCm39) |
L983P |
probably damaging |
Het |
| Sp110 |
A |
C |
1: 85,505,050 (GRCm39) |
F434C |
probably benign |
Het |
| Tbc1d10a |
A |
G |
11: 4,159,984 (GRCm39) |
Y123C |
probably damaging |
Het |
| Thbs4 |
A |
C |
13: 92,906,056 (GRCm39) |
I395S |
probably benign |
Het |
| Triml2 |
A |
G |
8: 43,646,776 (GRCm39) |
T422A |
probably benign |
Het |
| Ubn2 |
T |
C |
6: 38,417,382 (GRCm39) |
|
probably benign |
Het |
| Vmn1r15 |
T |
A |
6: 57,235,555 (GRCm39) |
M141K |
probably benign |
Het |
| Vmn2r80 |
A |
G |
10: 79,005,362 (GRCm39) |
E333G |
probably damaging |
Het |
| Zfp942 |
G |
A |
17: 22,148,083 (GRCm39) |
P182L |
probably benign |
Het |
|
| Other mutations in Zfp169 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01925:Zfp169
|
APN |
13 |
48,644,239 (GRCm39) |
unclassified |
probably benign |
|
|
IGL03329:Zfp169
|
APN |
13 |
48,644,270 (GRCm39) |
unclassified |
probably benign |
|
|
IGL03394:Zfp169
|
APN |
13 |
48,643,400 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
BB010:Zfp169
|
UTSW |
13 |
48,643,957 (GRCm39) |
missense |
unknown |
|
|
BB020:Zfp169
|
UTSW |
13 |
48,643,957 (GRCm39) |
missense |
unknown |
|
|
R0571:Zfp169
|
UTSW |
13 |
48,643,166 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1714:Zfp169
|
UTSW |
13 |
48,652,330 (GRCm39) |
missense |
probably benign |
0.35 |
|
R1784:Zfp169
|
UTSW |
13 |
48,643,295 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R3108:Zfp169
|
UTSW |
13 |
48,643,472 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R3689:Zfp169
|
UTSW |
13 |
48,660,377 (GRCm39) |
splice site |
probably benign |
|
|
R4444:Zfp169
|
UTSW |
13 |
48,643,813 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4665:Zfp169
|
UTSW |
13 |
48,644,339 (GRCm39) |
unclassified |
probably benign |
|
|
R4719:Zfp169
|
UTSW |
13 |
48,643,634 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4745:Zfp169
|
UTSW |
13 |
48,643,708 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R5288:Zfp169
|
UTSW |
13 |
48,643,751 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R5384:Zfp169
|
UTSW |
13 |
48,643,751 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R5979:Zfp169
|
UTSW |
13 |
48,644,516 (GRCm39) |
unclassified |
probably benign |
|
|
R6053:Zfp169
|
UTSW |
13 |
48,652,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6823:Zfp169
|
UTSW |
13 |
48,644,472 (GRCm39) |
unclassified |
probably benign |
|
|
R7084:Zfp169
|
UTSW |
13 |
48,652,339 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7679:Zfp169
|
UTSW |
13 |
48,651,859 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7933:Zfp169
|
UTSW |
13 |
48,643,957 (GRCm39) |
missense |
unknown |
|
|
R8298:Zfp169
|
UTSW |
13 |
48,651,853 (GRCm39) |
nonsense |
probably null |
|
|
R8322:Zfp169
|
UTSW |
13 |
48,644,575 (GRCm39) |
missense |
unknown |
|
|
R9047:Zfp169
|
UTSW |
13 |
48,652,292 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9124:Zfp169
|
UTSW |
13 |
48,644,557 (GRCm39) |
missense |
unknown |
|
|
R9126:Zfp169
|
UTSW |
13 |
48,644,557 (GRCm39) |
missense |
unknown |
|
|
R9131:Zfp169
|
UTSW |
13 |
48,644,557 (GRCm39) |
missense |
unknown |
|
|
R9132:Zfp169
|
UTSW |
13 |
48,644,557 (GRCm39) |
missense |
unknown |
|
|
| Posted On |
2016-08-02 |
Incidental Mutation