Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03382:Zfp942'

420749

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp942

Ensembl Gene

ENSMUSG00000071267

Gene Name

zinc finger protein 942

Synonyms

3110048L19Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.066) question?

Stock #

IGL03382

Quality Score

Status

Chromosome

Chromosomal Location

22145941-22181445 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 22148083 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Proline to Leucine at position 182 (P182L)

Ref Sequence

ENSEMBL: ENSMUSP00000089494 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000074295] [ENSMUST00000091879]

AlphaFold

B8JJA7

Predicted Effect

probably benign
Transcript: ENSMUST00000074295
AA Change: P182L

PolyPhen 2 Score 0.038 (Sensitivity: 0.94; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000073907
Gene: ENSMUSG00000071267
AA Change: P182L

Domain	Start	End	E-Value	Type
KRAB	13	69	6.55e-19	SMART
ZnF_C2H2	183	205	1.16e-1	SMART
ZnF_C2H2	211	233	8.22e-2	SMART
ZnF_C2H2	239	261	5.14e-3	SMART
ZnF_C2H2	267	289	8.02e-5	SMART
ZnF_C2H2	295	317	2.32e-1	SMART
ZnF_C2H2	323	345	1.6e-4	SMART
ZnF_C2H2	351	373	8.94e-3	SMART
ZnF_C2H2	379	401	1.95e-3	SMART
ZnF_C2H2	407	429	2.24e-3	SMART
ZnF_C2H2	435	457	7.49e-5	SMART
ZnF_C2H2	463	485	2.99e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000091879
AA Change: P182L

PolyPhen 2 Score 0.038 (Sensitivity: 0.94; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000089494
Gene: ENSMUSG00000071267
AA Change: P182L

Domain	Start	End	E-Value	Type
KRAB	13	69	6.55e-19	SMART
ZnF_C2H2	183	205	1.16e-1	SMART
ZnF_C2H2	211	233	8.22e-2	SMART
ZnF_C2H2	239	261	5.14e-3	SMART
ZnF_C2H2	267	289	8.02e-5	SMART
ZnF_C2H2	295	317	2.32e-1	SMART
ZnF_C2H2	323	345	1.6e-4	SMART
ZnF_C2H2	351	373	8.94e-3	SMART
ZnF_C2H2	379	401	1.95e-3	SMART
ZnF_C2H2	407	429	2.24e-3	SMART
ZnF_C2H2	435	457	7.49e-5	SMART
ZnF_C2H2	463	485	2.99e-4	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aff1	A	G	5: 103,988,926 (GRCm39)	D831G	possibly damaging	Het
Amer2	A	G	14: 60,617,331 (GRCm39)	K509E	possibly damaging	Het
Ankrd6	T	C	4: 32,808,771 (GRCm39)	K449E	probably damaging	Het
Atp8b2	G	A	3: 89,855,828 (GRCm39)	P459L	probably benign	Het
Atr	C	T	9: 95,802,875 (GRCm39)	R1846*	probably null	Het
Brd10	C	T	19: 29,694,676 (GRCm39)	G1606R	probably damaging	Het
Ccdc159	C	A	9: 21,842,992 (GRCm39)		probably null	Het
Ccna1	A	C	3: 54,954,698 (GRCm39)	Y338D	probably damaging	Het
Cpq	A	T	15: 33,213,089 (GRCm39)	E36V	probably damaging	Het
Cyp2c23	A	G	19: 44,003,371 (GRCm39)	I268T	probably damaging	Het
Dctn2	G	T	10: 127,114,057 (GRCm39)	Q332H	probably damaging	Het
Dnah17	T	A	11: 117,972,769 (GRCm39)	I2055F	probably damaging	Het
Dnmt3b	A	G	2: 153,528,279 (GRCm39)	H764R	probably damaging	Het
Gphn	T	A	12: 78,528,087 (GRCm39)	I135K	probably damaging	Het
Hnrnpul1	A	G	7: 25,450,409 (GRCm39)	M1T	probably null	Het
Htra4	T	C	8: 25,519,714 (GRCm39)	D406G	probably benign	Het
Klk10	G	T	7: 43,433,883 (GRCm39)		probably benign	Het
Lilrb4a	T	A	10: 51,367,616 (GRCm39)	W53R	probably benign	Het
Magel2	T	C	7: 62,028,461 (GRCm39)	V455A	probably benign	Het
Mrgprb5	T	C	7: 47,818,442 (GRCm39)	T98A	probably benign	Het
Mrps35	T	A	6: 146,951,373 (GRCm39)	C76*	probably null	Het
Myh7b	C	T	2: 155,465,399 (GRCm39)	R701C	probably damaging	Het
Nbeal1	G	A	1: 60,300,745 (GRCm39)		probably null	Het
Neb	T	A	2: 52,215,720 (GRCm39)	M196L	probably benign	Het
Nmd3	A	G	3: 69,642,421 (GRCm39)	K207R	probably damaging	Het
Plxna4	C	T	6: 32,179,129 (GRCm39)	R962Q	probably benign	Het
Pom121	T	C	5: 135,421,261 (GRCm39)	K230E	unknown	Het
Psme4	A	G	11: 30,757,788 (GRCm39)	D307G	possibly damaging	Het
Rnf41	T	G	10: 128,274,149 (GRCm39)	M267R	possibly damaging	Het
Sis	T	C	3: 72,836,052 (GRCm39)	N846D	probably benign	Het
Slc22a19	T	A	19: 7,659,227 (GRCm39)	I463L	probably benign	Het
Slc25a39	A	T	11: 102,297,030 (GRCm39)		probably null	Het
Slc35b2	C	T	17: 45,877,571 (GRCm39)	R233C	probably damaging	Het
Slc4a4	T	C	5: 89,376,695 (GRCm39)	L983P	probably damaging	Het
Sp110	A	C	1: 85,505,050 (GRCm39)	F434C	probably benign	Het
Tbc1d10a	A	G	11: 4,159,984 (GRCm39)	Y123C	probably damaging	Het
Thbs4	A	C	13: 92,906,056 (GRCm39)	I395S	probably benign	Het
Triml2	A	G	8: 43,646,776 (GRCm39)	T422A	probably benign	Het
Ubn2	T	C	6: 38,417,382 (GRCm39)		probably benign	Het
Vmn1r15	T	A	6: 57,235,555 (GRCm39)	M141K	probably benign	Het
Vmn2r80	A	G	10: 79,005,362 (GRCm39)	E333G	probably damaging	Het
Zfp169	T	C	13: 48,644,639 (GRCm39)		probably benign	Het

Other mutations in Zfp942

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00557:Zfp942	APN	17	22,148,042 (GRCm39)	missense	probably benign
IGL00586:Zfp942	APN	17	22,147,605 (GRCm39)	missense	probably damaging	1.00
IGL02973:Zfp942	APN	17	22,151,972 (GRCm39)	critical splice donor site	probably null
IGL03212:Zfp942	APN	17	22,148,445 (GRCm39)	nonsense	probably null
R0008:Zfp942	UTSW	17	22,147,319 (GRCm39)	missense	probably damaging	1.00
R0113:Zfp942	UTSW	17	22,148,066 (GRCm39)	missense	probably benign	0.18
R0244:Zfp942	UTSW	17	22,147,553 (GRCm39)	missense	probably benign	0.02
R0369:Zfp942	UTSW	17	22,148,017 (GRCm39)	missense	probably benign	0.41
R1664:Zfp942	UTSW	17	22,147,420 (GRCm39)	missense	possibly damaging	0.83
R1824:Zfp942	UTSW	17	22,147,522 (GRCm39)	missense	probably damaging	1.00
R4545:Zfp942	UTSW	17	22,147,285 (GRCm39)	missense	probably benign	0.00
R4785:Zfp942	UTSW	17	22,148,400 (GRCm39)	missense	probably damaging	1.00
R5493:Zfp942	UTSW	17	22,151,985 (GRCm39)	missense	probably null	0.66
R6568:Zfp942	UTSW	17	22,148,043 (GRCm39)	missense	probably benign	0.14
R6733:Zfp942	UTSW	17	22,147,733 (GRCm39)	nonsense	probably null
R7650:Zfp942	UTSW	17	22,147,818 (GRCm39)	missense	probably benign	0.07
R7935:Zfp942	UTSW	17	22,148,208 (GRCm39)	nonsense	probably null
R8065:Zfp942	UTSW	17	22,149,391 (GRCm39)	missense	probably damaging	0.96
R8067:Zfp942	UTSW	17	22,149,391 (GRCm39)	missense	probably damaging	0.96
R8237:Zfp942	UTSW	17	22,147,226 (GRCm39)	missense	possibly damaging	0.92
R8513:Zfp942	UTSW	17	22,147,282 (GRCm39)	missense	probably benign
R9468:Zfp942	UTSW	17	22,148,422 (GRCm39)	missense	probably benign	0.24
R9539:Zfp942	UTSW	17	22,148,014 (GRCm39)	missense	probably damaging	1.00
R9782:Zfp942	UTSW	17	22,147,463 (GRCm39)	missense	probably benign	0.05
X0025:Zfp942	UTSW	17	22,148,288 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02