Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03412:Il20rb'

421836

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Il20rb

Ensembl Gene

ENSMUSG00000044244

Gene Name

interleukin 20 receptor beta

Synonyms

LOC213208, Il20R2, Fndc6

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL03412

Quality Score

Status

Chromosome

Chromosomal Location

100339772-100368526 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 100357049 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 27 (V27A)

Ref Sequence

ENSEMBL: ENSMUSP00000096057 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000098458]

AlphaFold

E9Q9A6

Predicted Effect

probably benign
Transcript: ENSMUST00000098458
AA Change: V27A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000096057
Gene: ENSMUSG00000044244
AA Change: V27A

Domain	Start	End	E-Value	Type
FN3	30	117	9.09e0	SMART
Pfam:Interfer-bind	131	222	7.6e-9	PFAM
transmembrane domain	228	250	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000122880

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000152756

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20 (IL20; MIM 605619) (Blumberg et al., 2001 [PubMed 11163236]).[supplied by OMIM, Feb 2009]
PHENOTYPE: Mice homozygous for a knock-out allele display enhanced antigen-specific T cell responses. Mice homozygous for a reporter allele fail to exhibit epidermal hyperplasia in an interleukin-23 (IL-23)-dependent psoriasis mouse model. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam6b	A	T	12: 113,455,390 (GRCm39)	R736*	probably null	Het
Agpat2	T	C	2: 26,483,673 (GRCm39)	T255A	probably benign	Het
Akap3	G	A	6: 126,841,688 (GRCm39)	M102I	probably benign	Het
Cd300lb	C	A	11: 114,819,206 (GRCm39)	R5M	probably damaging	Het
Chrna5	A	T	9: 54,911,719 (GRCm39)	D69V	probably damaging	Het
Col9a1	G	A	1: 24,249,508 (GRCm39)		probably null	Het
Dnajb12	A	T	10: 59,725,895 (GRCm39)	H60L	probably benign	Het
Dnal1	T	A	12: 84,182,441 (GRCm39)	M1K	probably null	Het
Exoc7	C	T	11: 116,180,101 (GRCm39)	V655M	possibly damaging	Het
Fastkd3	A	G	13: 68,731,840 (GRCm39)	R54G	probably benign	Het
Fbln2	G	A	6: 91,248,763 (GRCm39)	D1143N	probably damaging	Het
Flii	C	T	11: 60,613,466 (GRCm39)	V174M	probably damaging	Het
Gtf2h4	T	C	17: 35,979,375 (GRCm39)	I388M	probably damaging	Het
Kidins220	T	C	12: 25,049,344 (GRCm39)	S320P	probably damaging	Het
Kif1b	T	C	4: 149,359,396 (GRCm39)	S114G	probably benign	Het
Lama3	T	C	18: 12,552,239 (GRCm39)	V397A	probably damaging	Het
Man2a2	A	T	7: 80,016,746 (GRCm39)	V356D	probably damaging	Het
Mcpt9	T	G	14: 56,265,484 (GRCm39)	T72P	probably damaging	Het
Mmd	T	C	11: 90,148,429 (GRCm39)		probably null	Het
Mroh2b	G	A	15: 4,973,854 (GRCm39)	R1124Q	probably benign	Het
Mvp	T	C	7: 126,592,735 (GRCm39)	D392G	probably damaging	Het
Mycbpap	T	A	11: 94,398,927 (GRCm39)		probably null	Het
Myh2	A	G	11: 67,080,395 (GRCm39)	H1203R	probably benign	Het
Nbeal1	T	A	1: 60,281,726 (GRCm39)	C816*	probably null	Het
Or4a70	T	A	2: 89,324,555 (GRCm39)	I34F	probably benign	Het
Or5an6	A	T	19: 12,371,743 (GRCm39)	T39S	probably damaging	Het
Pcdh12	C	T	18: 38,416,568 (GRCm39)	V186M	probably benign	Het
Pik3c2a	C	T	7: 116,017,074 (GRCm39)	E228K	probably benign	Het
Plcz1	A	C	6: 139,961,823 (GRCm39)	Y243D	probably damaging	Het
Rspo3	T	A	10: 29,411,270 (GRCm39)	I19F	possibly damaging	Het
Slc2a12	T	C	10: 22,540,868 (GRCm39)	L241P	probably damaging	Het
Slc4a10	G	A	2: 62,080,887 (GRCm39)		probably benign	Het
Snai2	A	T	16: 14,525,120 (GRCm39)	T209S	possibly damaging	Het
Sorcs2	T	C	5: 36,203,848 (GRCm39)	D549G	probably damaging	Het
Srsf12	G	A	4: 33,230,929 (GRCm39)	R141Q	probably damaging	Het
Stab1	T	G	14: 30,876,364 (GRCm39)	E908D	probably benign	Het
Stat6	A	T	10: 127,494,074 (GRCm39)	M634L	probably benign	Het
Tex21	A	G	12: 76,291,780 (GRCm39)		probably null	Het
Tsc2	C	A	17: 24,816,042 (GRCm39)	R1715L	probably damaging	Het
Ttll4	A	G	1: 74,726,480 (GRCm39)	I693V	probably benign	Het
Vmn1r5	A	T	6: 56,962,918 (GRCm39)	M198L	possibly damaging	Het
Vmn1r50	T	C	6: 90,085,007 (GRCm39)	Y251H	probably damaging	Het
Vmn2r59	A	G	7: 41,661,862 (GRCm39)	I651T	probably benign	Het
Wdr3	G	T	3: 100,059,293 (GRCm39)	T342K	probably benign	Het
Zbtb44	A	G	9: 30,964,763 (GRCm39)	T58A	probably benign	Het
Zeb2	A	G	2: 44,892,720 (GRCm39)		probably benign	Het
Zmym2	C	T	14: 57,197,176 (GRCm39)	Q1315*	probably null	Het
Zmym6	T	C	4: 126,986,731 (GRCm39)	I137T	probably damaging	Het

Other mutations in Il20rb

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01490:Il20rb	APN	9	100,355,207 (GRCm39)	missense	probably damaging	1.00
IGL02943:Il20rb	APN	9	100,348,305 (GRCm39)	missense	probably benign	0.00
IGL03368:Il20rb	APN	9	100,341,174 (GRCm39)	utr 3 prime	probably benign
IGL03396:Il20rb	APN	9	100,341,251 (GRCm39)	missense	probably damaging	0.99
R0157:Il20rb	UTSW	9	100,355,132 (GRCm39)	missense	probably damaging	1.00
R4591:Il20rb	UTSW	9	100,357,043 (GRCm39)	missense	possibly damaging	0.61
R4948:Il20rb	UTSW	9	100,343,592 (GRCm39)	splice site	probably benign
R5622:Il20rb	UTSW	9	100,368,371 (GRCm39)	missense	probably benign	0.15
R6448:Il20rb	UTSW	9	100,356,986 (GRCm39)	missense	probably benign	0.03
R7013:Il20rb	UTSW	9	100,343,481 (GRCm39)	missense	probably benign	0.10
R7502:Il20rb	UTSW	9	100,350,479 (GRCm39)	missense	probably damaging	0.98
R7916:Il20rb	UTSW	9	100,348,304 (GRCm39)	missense	probably benign	0.01
R8015:Il20rb	UTSW	9	100,356,947 (GRCm39)	missense	probably damaging	1.00
R8234:Il20rb	UTSW	9	100,341,263 (GRCm39)	missense	probably benign	0.01
R9143:Il20rb	UTSW	9	100,356,936 (GRCm39)	missense	probably damaging	1.00
R9381:Il20rb	UTSW	9	100,343,541 (GRCm39)	missense	possibly damaging	0.60
R9450:Il20rb	UTSW	9	100,355,055 (GRCm39)	missense	possibly damaging	0.47
R9595:Il20rb	UTSW	9	100,368,311 (GRCm39)	missense	possibly damaging	0.91
R9727:Il20rb	UTSW	9	100,357,001 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02