Mutagenetix > Incidental Mutation

Incidental Mutation 'R5622:Il20rb'

441640

Institutional Source

Beutler Lab

Gene Symbol

Il20rb

Ensembl Gene

ENSMUSG00000044244

Gene Name

interleukin 20 receptor beta

Synonyms

LOC213208, Il20R2, Fndc6

MMRRC Submission

043161-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R5622 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

100339772-100368526 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 100368371 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Leucine at position 4 (Q4L)

Ref Sequence

ENSEMBL: ENSMUSP00000096057 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000098458]

AlphaFold

E9Q9A6

Predicted Effect

probably benign
Transcript: ENSMUST00000098458
AA Change: Q4L

PolyPhen 2 Score 0.150 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000096057
Gene: ENSMUSG00000044244
AA Change: Q4L

Domain	Start	End	E-Value	Type
FN3	30	117	9.09e0	SMART
Pfam:Interfer-bind	131	222	7.6e-9	PFAM
transmembrane domain	228	250	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000122880

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.4%
3x: 98.7%
10x: 97.2%
20x: 95.2%

Validation Efficiency

97% (69/71)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20 (IL20; MIM 605619) (Blumberg et al., 2001 [PubMed 11163236]).[supplied by OMIM, Feb 2009]
PHENOTYPE: Mice homozygous for a knock-out allele display enhanced antigen-specific T cell responses. Mice homozygous for a reporter allele fail to exhibit epidermal hyperplasia in an interleukin-23 (IL-23)-dependent psoriasis mouse model. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 67 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca17	A	T	17: 24,546,642 (GRCm39)	S320T	probably benign	Het
Alg8	T	A	7: 97,036,006 (GRCm39)		probably benign	Het
Anp32b	G	A	4: 46,469,930 (GRCm39)	E202K	unknown	Het
Apcdd1	A	G	18: 63,069,973 (GRCm39)		probably null	Het
Apobec2	A	G	17: 48,730,444 (GRCm39)	V74A	possibly damaging	Het
Arid3c	A	T	4: 41,729,959 (GRCm39)	C79S	probably benign	Het
Atp1a2	A	T	1: 172,118,994 (GRCm39)		probably benign	Het
B2m	A	T	2: 121,981,471 (GRCm39)	N62I	probably damaging	Het
Borcs5	T	C	6: 134,663,086 (GRCm39)		probably null	Het
Ccn1	A	G	3: 145,355,075 (GRCm39)	L60P	probably damaging	Het
Cdk11b	A	G	4: 155,714,674 (GRCm39)	K127E	probably damaging	Het
Cep170	T	C	1: 176,563,433 (GRCm39)	H726R	possibly damaging	Het
Col5a2	A	C	1: 45,466,219 (GRCm39)	S190A	probably benign	Het
Cryba4	T	C	5: 112,398,990 (GRCm39)	D5G	probably damaging	Het
Cyp2a5	T	G	7: 26,535,299 (GRCm39)	V87G	probably damaging	Het
Dcaf8	A	G	1: 172,013,965 (GRCm39)		probably benign	Het
Dchs1	A	G	7: 105,404,500 (GRCm39)	S2681P	probably benign	Het
Ddx20	A	G	3: 105,586,327 (GRCm39)	S673P	probably damaging	Het
Deptor	T	A	15: 55,044,428 (GRCm39)	I198N	probably damaging	Het
Ebf2	T	C	14: 67,628,007 (GRCm39)	I334T	possibly damaging	Het
F5	A	G	1: 164,020,134 (GRCm39)	R870G	probably benign	Het
Flg2	A	C	3: 93,109,871 (GRCm39)	H633P	unknown	Het
Gm11938	T	A	11: 99,494,119 (GRCm39)		probably null	Het
Gm6370	A	G	5: 146,430,708 (GRCm39)	T298A	probably benign	Het
H60b	C	A	10: 22,159,441 (GRCm39)		probably benign	Het
Hsbp1	A	G	8: 120,071,324 (GRCm39)	T4A	possibly damaging	Het
Hsd3b3	A	T	3: 98,649,524 (GRCm39)	D266E	possibly damaging	Het
Ift172	T	C	5: 31,440,426 (GRCm39)	Y287C	probably damaging	Het
Krt5	T	C	15: 101,617,470 (GRCm39)	D421G	probably damaging	Het
Lonp1	G	C	17: 56,927,263 (GRCm39)	A330G	probably benign	Het
Me3	A	G	7: 89,445,871 (GRCm39)	D196G	probably damaging	Het
Mfsd12	T	A	10: 81,199,461 (GRCm39)	V451E	probably null	Het
Mib1	A	G	18: 10,794,503 (GRCm39)	N663S	possibly damaging	Het
Mtus2	A	T	5: 148,015,244 (GRCm39)	N679I	probably benign	Het
Myt1	A	G	2: 181,438,915 (GRCm39)	T146A	probably benign	Het
Neb	T	A	2: 52,160,281 (GRCm39)	H2244L	probably damaging	Het
Or51l4	T	C	7: 103,404,376 (GRCm39)	T139A	probably damaging	Het
Or5b21	A	C	19: 12,839,663 (GRCm39)	I175L	probably benign	Het
Or5p81	C	T	7: 108,267,289 (GRCm39)	T222I	probably benign	Het
Pabpc4	A	G	4: 123,185,524 (GRCm39)		probably null	Het
Padi1	C	A	4: 140,552,266 (GRCm39)	V393L	probably damaging	Het
Pax2	A	T	19: 44,806,905 (GRCm39)	D300V	probably damaging	Het
Pcgf2	T	C	11: 97,581,078 (GRCm39)	E71G	probably damaging	Het
Pi4kb	A	G	3: 94,906,172 (GRCm39)	Q573R	possibly damaging	Het
Pitpna	T	A	11: 75,511,153 (GRCm39)	M242K	possibly damaging	Het
Pkd1	A	G	17: 24,793,014 (GRCm39)	E1567G	possibly damaging	Het
Plcb2	A	T	2: 118,545,210 (GRCm39)	S630R	probably damaging	Het
Prrt2	A	T	7: 126,618,937 (GRCm39)	V176D	probably benign	Het
Prss1l	A	C	6: 41,373,084 (GRCm39)	N119H	probably damaging	Het
Prss42	T	C	9: 110,628,490 (GRCm39)		probably null	Het
Rhoq	A	G	17: 87,304,459 (GRCm39)	R197G	probably benign	Het
Rin2	A	T	2: 145,702,299 (GRCm39)	T332S	probably benign	Het
Rnps1-ps	C	T	6: 7,982,605 (GRCm39)		noncoding transcript	Het
Rp1	A	T	1: 4,418,060 (GRCm39)	N1017K	possibly damaging	Het
Setbp1	T	A	18: 78,900,700 (GRCm39)	Y989F	probably damaging	Het
Slc11a1	G	A	1: 74,420,065 (GRCm39)	G191D	probably damaging	Het
Slc35f5	G	A	1: 125,517,693 (GRCm39)	R497Q	probably damaging	Het
Slf1	T	C	13: 77,198,090 (GRCm39)	K728R	probably benign	Het
Tiparp	T	G	3: 65,454,946 (GRCm39)	S364A	probably benign	Het
Tph1	G	A	7: 46,296,969 (GRCm39)	Q409*	probably null	Het
Trp73	A	T	4: 154,145,049 (GRCm39)	I526N	possibly damaging	Het
Ttc9c	G	A	19: 8,793,332 (GRCm39)	R103*	probably null	Het
Vmn2r75	T	A	7: 85,797,702 (GRCm39)	I704F	probably benign	Het
Wdr76	A	G	2: 121,348,216 (GRCm39)	R63G	probably damaging	Het
Zc3h3	T	A	15: 75,648,928 (GRCm39)	S735C	probably damaging	Het
Zfp383	G	A	7: 29,611,615 (GRCm39)	V32M	probably damaging	Het
Zfp810	T	A	9: 22,190,392 (GRCm39)	Y172F	probably benign	Het

Other mutations in Il20rb

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01490:Il20rb	APN	9	100,355,207 (GRCm39)	missense	probably damaging	1.00
IGL02943:Il20rb	APN	9	100,348,305 (GRCm39)	missense	probably benign	0.00
IGL03368:Il20rb	APN	9	100,341,174 (GRCm39)	utr 3 prime	probably benign
IGL03396:Il20rb	APN	9	100,341,251 (GRCm39)	missense	probably damaging	0.99
IGL03412:Il20rb	APN	9	100,357,049 (GRCm39)	missense	probably benign	0.00
R0157:Il20rb	UTSW	9	100,355,132 (GRCm39)	missense	probably damaging	1.00
R4591:Il20rb	UTSW	9	100,357,043 (GRCm39)	missense	possibly damaging	0.61
R4948:Il20rb	UTSW	9	100,343,592 (GRCm39)	splice site	probably benign
R6448:Il20rb	UTSW	9	100,356,986 (GRCm39)	missense	probably benign	0.03
R7013:Il20rb	UTSW	9	100,343,481 (GRCm39)	missense	probably benign	0.10
R7502:Il20rb	UTSW	9	100,350,479 (GRCm39)	missense	probably damaging	0.98
R7916:Il20rb	UTSW	9	100,348,304 (GRCm39)	missense	probably benign	0.01
R8015:Il20rb	UTSW	9	100,356,947 (GRCm39)	missense	probably damaging	1.00
R8234:Il20rb	UTSW	9	100,341,263 (GRCm39)	missense	probably benign	0.01
R9143:Il20rb	UTSW	9	100,356,936 (GRCm39)	missense	probably damaging	1.00
R9381:Il20rb	UTSW	9	100,343,541 (GRCm39)	missense	possibly damaging	0.60
R9450:Il20rb	UTSW	9	100,355,055 (GRCm39)	missense	possibly damaging	0.47
R9595:Il20rb	UTSW	9	100,368,311 (GRCm39)	missense	possibly damaging	0.91
R9727:Il20rb	UTSW	9	100,357,001 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CCAAATAGAATGCAGGCATTTGAGATG -3'
(R):5'- ATTTTGAGCATTTGGGCCAGC -3'

Sequencing Primer
(F):5'- TGAGATGCGAAAATGGAGATTAAAAG -3'
(R):5'- AGCTCCCCTTTCAGAACTGTTCAAG -3'

Posted On

2016-11-08