Incidental Mutation 'R5583:Styx'
ID 438587
Institutional Source Beutler Lab
Gene Symbol Styx
Ensembl Gene ENSMUSG00000053205
Gene Name serine/threonine/tyrosine interaction protein
Synonyms 0610039A20Rik, STNS (alternatively spliced intron of Styx)
MMRRC Submission 043137-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.228) question?
Stock # R5583 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 45588534-45614608 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 45608483 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 147 (F147I)
Ref Sequence ENSEMBL: ENSMUSP00000107466 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000111835] [ENSMUST00000226303] [ENSMUST00000226603] [ENSMUST00000226785] [ENSMUST00000226873] [ENSMUST00000228311] [ENSMUST00000228818]
AlphaFold Q60969
Predicted Effect possibly damaging
Transcript: ENSMUST00000111835
AA Change: F147I

PolyPhen 2 Score 0.718 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000107466
Gene: ENSMUSG00000053205
AA Change: F147I

DomainStartEndE-ValueType
DSPc 28 173 2.71e-64 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000226303
Predicted Effect probably benign
Transcript: ENSMUST00000226603
Predicted Effect probably benign
Transcript: ENSMUST00000226785
Predicted Effect possibly damaging
Transcript: ENSMUST00000226873
AA Change: F147I

PolyPhen 2 Score 0.527 (Sensitivity: 0.88; Specificity: 0.90)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000227538
Predicted Effect possibly damaging
Transcript: ENSMUST00000228311
AA Change: F147I

PolyPhen 2 Score 0.527 (Sensitivity: 0.88; Specificity: 0.90)
Predicted Effect probably benign
Transcript: ENSMUST00000228818
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228321
Meta Mutation Damage Score 0.1430 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.4%
  • 20x: 95.4%
Validation Efficiency 97% (60/62)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a pseudophosphatase, able to bind potential substrates but lacking an active catalytic loop. The encoded protein may be involved in spermiogenesis. Two transcript variants encoding the same protein have been found for these genes. [provided by RefSeq, Oct 2011]
PHENOTYPE: Males homozygous for a targeted null mutation are sterile due to a deficiency of germ cells at the immature, round, and elongating spermatid stages. Residual epididymal sperm have head abnormalities. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A1bg A T 15: 60,793,083 (GRCm39) L8Q probably damaging Het
Abca4 T C 3: 121,942,550 (GRCm39) V1681A probably damaging Het
Abce1 G T 8: 80,416,922 (GRCm39) A363E probably benign Het
Adgrl2 T C 3: 148,564,800 (GRCm39) Y256C probably damaging Het
Afm T C 5: 90,695,740 (GRCm39) C416R probably damaging Het
Ahnak T A 19: 8,984,281 (GRCm39) V1855D probably damaging Het
Alb A T 5: 90,616,452 (GRCm39) H319L probably benign Het
Ankrd35 G T 3: 96,592,219 (GRCm39) R835L probably damaging Het
Atg2b T C 12: 105,615,414 (GRCm39) D1014G possibly damaging Het
Cdk6 T A 5: 3,394,436 (GRCm39) Y24N probably damaging Het
Chd7 T A 4: 8,752,473 (GRCm39) N323K probably damaging Het
Cops9 A T 1: 92,567,489 (GRCm39) probably benign Het
Crybg1 T C 10: 43,879,506 (GRCm39) T561A probably benign Het
Dcdc5 T C 2: 106,195,778 (GRCm39) noncoding transcript Het
Dnah7b G T 1: 46,281,359 (GRCm39) A2807S probably benign Het
Fam149b A G 14: 20,413,368 (GRCm39) T196A possibly damaging Het
Fam217a C A 13: 35,094,280 (GRCm39) C402F probably damaging Het
Fat2 A T 11: 55,144,715 (GRCm39) V4053E probably benign Het
Fcgbp T C 7: 27,791,004 (GRCm39) V755A probably damaging Het
Fxr1 C A 3: 34,123,125 (GRCm39) S641R probably benign Het
Gata5 A T 2: 179,976,047 (GRCm39) M39K probably benign Het
Gon4l T A 3: 88,807,278 (GRCm39) D1658E probably damaging Het
Gpr180 C T 14: 118,400,110 (GRCm39) T426M probably damaging Het
Gtf2h3 C T 5: 124,722,360 (GRCm39) T121I probably benign Het
Helq T C 5: 100,910,459 (GRCm39) E1039G probably damaging Het
Hibch T A 1: 52,940,406 (GRCm39) Y192N probably damaging Het
Hp1bp3 A G 4: 137,949,426 (GRCm39) I41M probably damaging Het
Itpripl2 G T 7: 118,089,101 (GRCm39) P486Q probably benign Het
Kcnj6 T C 16: 94,634,060 (GRCm39) D17G probably benign Het
Kprp T A 3: 92,731,643 (GRCm39) Y469F unknown Het
Kremen2 T C 17: 23,961,229 (GRCm39) T373A probably benign Het
Lgi4 A G 7: 30,760,562 (GRCm39) Y39C possibly damaging Het
Lgr5 T C 10: 115,314,409 (GRCm39) D176G probably benign Het
Lrp1 T C 10: 127,424,332 (GRCm39) S785G probably benign Het
Ltbp1 A T 17: 75,598,325 (GRCm39) Q920L probably benign Het
Map2 A G 1: 66,455,196 (GRCm39) E1362G probably damaging Het
Nkx2-6 T C 14: 69,409,272 (GRCm39) S8P probably damaging Het
Or2h1b T C 17: 37,462,485 (GRCm39) Q126R probably benign Het
Pde4dip C T 3: 97,654,892 (GRCm39) R888Q possibly damaging Het
Per1 A G 11: 68,994,271 (GRCm39) H494R probably damaging Het
Pira2 A G 7: 3,845,545 (GRCm39) F280L probably benign Het
Plekhm3 C T 1: 64,977,145 (GRCm39) W108* probably null Het
Ptcd3 A G 6: 71,879,920 (GRCm39) S113P probably damaging Het
Scarf1 T C 11: 75,404,842 (GRCm39) L42P possibly damaging Het
Scart2 G A 7: 139,876,739 (GRCm39) C710Y probably damaging Het
Skint1 A C 4: 111,876,253 (GRCm39) Q58P probably damaging Het
Spata7 A T 12: 98,635,590 (GRCm39) N438I probably damaging Het
Spdya C A 17: 71,876,126 (GRCm39) D164E probably damaging Het
Speer3 G A 5: 13,844,782 (GRCm39) probably null Het
Ssc4d A T 5: 135,999,050 (GRCm39) L51H probably damaging Het
Steap1 A G 5: 5,790,579 (GRCm39) I123T possibly damaging Het
Suv39h2 T A 2: 3,475,890 (GRCm39) probably benign Het
Tfb2m A G 1: 179,373,446 (GRCm39) V84A probably benign Het
Tlcd1 T G 11: 78,069,762 (GRCm39) V25G probably benign Het
Tmem79 T C 3: 88,239,870 (GRCm39) Y280C probably damaging Het
Trim5 T A 7: 103,926,042 (GRCm39) N173I probably damaging Het
Ttc17 A T 2: 94,208,027 (GRCm39) D194E probably damaging Het
Zfp2 T C 11: 50,790,984 (GRCm39) E353G possibly damaging Het
Other mutations in Styx
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02501:Styx APN 14 45,609,922 (GRCm39) missense probably benign
R0464:Styx UTSW 14 45,609,908 (GRCm39) missense probably benign 0.00
R1772:Styx UTSW 14 45,594,215 (GRCm39) missense probably damaging 1.00
R2067:Styx UTSW 14 45,611,020 (GRCm39) missense probably benign 0.01
R2289:Styx UTSW 14 45,592,404 (GRCm39) missense possibly damaging 0.65
R5127:Styx UTSW 14 45,610,961 (GRCm39) splice site probably null
R5755:Styx UTSW 14 45,605,910 (GRCm39) missense probably benign 0.40
R5982:Styx UTSW 14 45,605,909 (GRCm39) missense probably benign 0.43
R7078:Styx UTSW 14 45,609,873 (GRCm39) missense probably benign 0.01
X0023:Styx UTSW 14 45,596,724 (GRCm39) missense probably benign 0.04
Predicted Primers PCR Primer
(F):5'- ACCATGACACATCACCTCTCTATTG -3'
(R):5'- TGCACAGTGATATGCCTGCC -3'

Sequencing Primer
(F):5'- GCCTTGCATTAGCTAAGCAG -3'
(R):5'- AGATCTCGCTGAATTCCAGG -3'
Posted On 2016-10-26