Incidental Mutation 'R5639:Or10k2'
ID 440547
Institutional Source Beutler Lab
Gene Symbol Or10k2
Ensembl Gene ENSMUSG00000047286
Gene Name olfactory receptor family 10 subfamily K member 2
Synonyms Olfr370, GA_x6K02T2NUPS-11609807-11610751, MOR267-16
MMRRC Submission 043288-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.111) question?
Stock # R5639 (G1)
Quality Score 225
Status Not validated
Chromosome 8
Chromosomal Location 84267722-84268817 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 84267973 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 67 (S67P)
Ref Sequence ENSEMBL: ENSMUSP00000149251 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058609] [ENSMUST00000209408] [ENSMUST00000214156]
AlphaFold E9Q848
Predicted Effect probably damaging
Transcript: ENSMUST00000058609
AA Change: S67P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000055435
Gene: ENSMUSG00000047286
AA Change: S67P

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.6e-44 PFAM
Pfam:7tm_1 41 290 6.2e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000209408
AA Change: S67P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000214156
AA Change: S67P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aars1 T C 8: 111,769,866 (GRCm39) Y322H probably benign Het
Aldh1a1 C A 19: 20,600,786 (GRCm39) T201K probably damaging Het
Ankrd26 T C 6: 118,516,685 (GRCm39) E493G possibly damaging Het
Armc8 A G 9: 99,378,202 (GRCm39) probably null Het
Bicc1 A T 10: 70,776,350 (GRCm39) V701E probably damaging Het
Car11 T A 7: 45,352,045 (GRCm39) probably null Het
Ccn1 A C 3: 145,354,452 (GRCm39) V153G probably damaging Het
Celsr1 C G 15: 85,914,968 (GRCm39) V1002L probably damaging Het
Clpx T A 9: 65,237,112 (GRCm39) S597T probably benign Het
Cplx3 A T 9: 57,519,149 (GRCm39) F266I probably benign Het
Dmpk A G 7: 18,826,525 (GRCm39) M545V probably benign Het
Dnah7c C G 1: 46,778,828 (GRCm39) D3139E probably benign Het
Drd5 T A 5: 38,477,178 (GRCm39) V57D possibly damaging Het
Epc2 A G 2: 49,341,903 (GRCm39) N29S possibly damaging Het
Ercc3 T C 18: 32,398,767 (GRCm39) V682A probably damaging Het
Fam186a T C 15: 99,844,931 (GRCm39) K438E unknown Het
Farp1 T A 14: 121,512,794 (GRCm39) I764N probably damaging Het
Flvcr2 A T 12: 85,794,250 (GRCm39) I209F probably benign Het
Fndc3b C T 3: 27,480,302 (GRCm39) V1065M probably damaging Het
Gm11595 G A 11: 99,663,381 (GRCm39) R100C unknown Het
Gp6 C A 7: 4,397,130 (GRCm39) D102Y probably damaging Het
Gpc5 T C 14: 115,330,179 (GRCm39) L114P probably benign Het
Kcnq3 T A 15: 65,869,599 (GRCm39) E613V probably damaging Het
Krt74 T G 15: 101,665,195 (GRCm39) noncoding transcript Het
Lipe T C 7: 25,082,750 (GRCm39) T801A probably benign Het
Lrp1 A G 10: 127,429,708 (GRCm39) V454A probably damaging Het
Lsm14a T C 7: 34,052,935 (GRCm39) D338G probably damaging Het
Mctp1 T C 13: 77,172,902 (GRCm39) silent Het
Nlrp4a G A 7: 26,156,455 (GRCm39) A727T probably benign Het
Nrgn T C 9: 37,457,344 (GRCm39) S48G probably benign Het
Oga A G 19: 45,765,438 (GRCm39) I123T probably damaging Het
Or4a73 T C 2: 89,421,069 (GRCm39) Y130C probably damaging Het
Or51f23 A G 7: 102,453,200 (GRCm39) S172G probably benign Het
Pdia6 A G 12: 17,328,594 (GRCm39) E183G probably benign Het
Pign T A 1: 105,517,040 (GRCm39) I529F probably benign Het
Plscr5 A T 9: 92,087,564 (GRCm39) K178* probably null Het
Samm50 T G 15: 84,098,329 (GRCm39) I456S probably benign Het
Sesn1 A G 10: 41,687,267 (GRCm39) R84G probably benign Het
Skint8 C A 4: 111,807,390 (GRCm39) L359M probably damaging Het
Spag17 G T 3: 99,963,482 (GRCm39) D1067Y probably damaging Het
Sptan1 C T 2: 29,881,005 (GRCm39) Q425* probably null Het
Srrm4 T A 5: 116,729,418 (GRCm39) I36F unknown Het
Tas1r2 A T 4: 139,387,107 (GRCm39) S189C probably damaging Het
Tep1 A G 14: 51,091,062 (GRCm39) V690A possibly damaging Het
Trmo T C 4: 46,382,073 (GRCm39) K348R probably benign Het
Trmu T A 15: 85,766,899 (GRCm39) M36K probably damaging Het
Ubr4 A G 4: 139,179,959 (GRCm39) T3380A possibly damaging Het
Unc79 A C 12: 103,137,831 (GRCm39) T2425P probably damaging Het
Vmn2r12 G A 5: 109,240,666 (GRCm39) T149I probably benign Het
Vwa3a A C 7: 120,389,366 (GRCm39) K68T probably damaging Het
Yif1a T C 19: 5,138,778 (GRCm39) probably null Het
Zbtb44 A T 9: 30,965,348 (GRCm39) T253S probably damaging Het
Zdhhc3 T C 9: 122,929,410 (GRCm39) Y75C probably damaging Het
Zfp189 T A 4: 49,530,153 (GRCm39) F419I probably benign Het
Zfp663 T C 2: 165,194,929 (GRCm39) D430G probably benign Het
Zfp709 T G 8: 72,643,835 (GRCm39) probably null Het
Other mutations in Or10k2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01621:Or10k2 APN 8 84,268,247 (GRCm39) missense probably benign 0.00
IGL02481:Or10k2 APN 8 84,268,015 (GRCm39) missense possibly damaging 0.70
IGL02499:Or10k2 APN 8 84,267,812 (GRCm39) missense possibly damaging 0.83
IGL02832:Or10k2 APN 8 84,268,100 (GRCm39) missense probably damaging 1.00
R0315:Or10k2 UTSW 8 84,268,001 (GRCm39) missense possibly damaging 0.90
R0330:Or10k2 UTSW 8 84,268,142 (GRCm39) missense probably damaging 1.00
R1737:Or10k2 UTSW 8 84,268,045 (GRCm39) missense probably benign 0.05
R1973:Or10k2 UTSW 8 84,268,421 (GRCm39) missense probably benign 0.00
R2157:Or10k2 UTSW 8 84,268,250 (GRCm39) missense probably benign 0.00
R4687:Or10k2 UTSW 8 84,268,489 (GRCm39) missense probably damaging 1.00
R6150:Or10k2 UTSW 8 84,267,782 (GRCm39) missense probably benign 0.02
R6590:Or10k2 UTSW 8 84,267,904 (GRCm39) missense probably benign 0.08
R6682:Or10k2 UTSW 8 84,268,187 (GRCm39) missense probably benign 0.00
R6690:Or10k2 UTSW 8 84,267,904 (GRCm39) missense probably benign 0.08
R7846:Or10k2 UTSW 8 84,268,526 (GRCm39) missense probably damaging 1.00
R7886:Or10k2 UTSW 8 84,268,576 (GRCm39) missense possibly damaging 0.95
R8349:Or10k2 UTSW 8 84,268,301 (GRCm39) missense probably damaging 1.00
R8361:Or10k2 UTSW 8 84,268,715 (GRCm39) missense possibly damaging 0.86
R8449:Or10k2 UTSW 8 84,268,301 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CATCTGGGGCTGATCTCTGATG -3'
(R):5'- ATCGATCATAACCCATGGCTG -3'

Sequencing Primer
(F):5'- CCTCCATGGAGTGTGTAAATGACAC -3'
(R):5'- TAACCCATGGCTGCCAGC -3'
Posted On 2016-11-08