Incidental Mutation 'R5758:Or5p72'
ID 445143
Institutional Source Beutler Lab
Gene Symbol Or5p72
Ensembl Gene ENSMUSG00000095239
Gene Name olfactory receptor family 5 subfamily P member 72
Synonyms MOR204-9, GA_x6K02T2PBJ9-10752603-10753547, Olfr497
MMRRC Submission 043203-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # R5758 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 108021780-108022724 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 108022369 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Aspartic acid at position 197 (V197D)
Ref Sequence ENSEMBL: ENSMUSP00000150439 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076406] [ENSMUST00000213521]
AlphaFold Q8VG08
Predicted Effect probably benign
Transcript: ENSMUST00000076406
AA Change: V197D

PolyPhen 2 Score 0.020 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000075741
Gene: ENSMUSG00000095239
AA Change: V197D

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 5.5e-55 PFAM
Pfam:7tm_1 44 293 1.4e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211454
AA Change: V197D
Predicted Effect probably benign
Transcript: ENSMUST00000213521
AA Change: V197D

PolyPhen 2 Score 0.020 (Sensitivity: 0.95; Specificity: 0.80)
Coding Region Coverage
  • 1x: 99.5%
  • 3x: 98.8%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 A G 11: 9,264,536 (GRCm39) N2973D probably damaging Het
Acan A T 7: 78,750,962 (GRCm39) E1911V possibly damaging Het
Adamts20 T C 15: 94,292,531 (GRCm39) N193S probably benign Het
Arhgap28 T C 17: 68,180,154 (GRCm39) D81G probably benign Het
Calhm3 A G 19: 47,140,190 (GRCm39) V301A probably damaging Het
Celsr1 C T 15: 85,825,465 (GRCm39) G1556D probably benign Het
Cfap221 A G 1: 119,862,288 (GRCm39) L598P probably benign Het
Col6a6 T C 9: 105,638,717 (GRCm39) probably null Het
Dmxl2 T A 9: 54,380,248 (GRCm39) I142F probably benign Het
Dpy19l4 C T 4: 11,276,886 (GRCm39) V338M probably damaging Het
Dpys A C 15: 39,690,395 (GRCm39) D319E possibly damaging Het
Dsc3 A G 18: 20,122,591 (GRCm39) V111A probably damaging Het
Galnt5 T C 2: 57,888,442 (GRCm39) V14A probably benign Het
Hebp2 C A 10: 18,420,155 (GRCm39) V93L probably damaging Het
Igkv8-21 A T 6: 70,292,009 (GRCm39) S78T possibly damaging Het
Jak2 T A 19: 29,287,043 (GRCm39) D1036E probably damaging Het
Kazn A G 4: 141,868,982 (GRCm39) probably null Het
Kif9 T C 9: 110,318,947 (GRCm39) V143A probably damaging Het
Lhcgr T C 17: 89,049,976 (GRCm39) I517V probably damaging Het
Llgl1 T C 11: 60,599,393 (GRCm39) F458S probably damaging Het
Mrgprb3 C A 7: 48,293,067 (GRCm39) M161I probably benign Het
Muc5b A T 7: 141,412,720 (GRCm39) I1889F unknown Het
Mysm1 A G 4: 94,840,598 (GRCm39) V606A probably damaging Het
Nipal3 T C 4: 135,179,874 (GRCm39) D348G probably benign Het
Olfml2b G A 1: 170,496,833 (GRCm39) probably null Het
Or5p5 T C 7: 107,414,022 (GRCm39) V77A probably damaging Het
Orc5 T C 5: 22,734,256 (GRCm39) D176G possibly damaging Het
Rapgef6 A G 11: 54,559,470 (GRCm39) N1041S probably damaging Het
Ryr3 G A 2: 112,672,320 (GRCm39) R1384C probably damaging Het
Sar1a A G 10: 61,520,851 (GRCm39) Y22C probably benign Het
Shcbp1 T C 8: 4,799,355 (GRCm39) probably null Het
Smim17 C T 7: 6,427,788 (GRCm39) H25Y possibly damaging Het
Tcstv7a T C 13: 120,289,791 (GRCm39) D135G probably damaging Het
Trim10 C T 17: 37,188,044 (GRCm39) T420I possibly damaging Het
Trip13 G T 13: 74,085,614 (GRCm39) S29R probably benign Het
Tubgcp5 C T 7: 55,468,643 (GRCm39) R713C probably damaging Het
Uckl1 C A 2: 181,211,746 (GRCm39) G420C probably damaging Het
Vangl1 A T 3: 102,091,408 (GRCm39) V226D probably damaging Het
Zdhhc17 A G 10: 110,780,256 (GRCm39) *633Q probably null Het
Zfhx4 A G 3: 5,467,680 (GRCm39) K2613E probably damaging Het
Zfp236 G A 18: 82,689,834 (GRCm39) T215M probably damaging Het
Zfp563 A G 17: 33,323,894 (GRCm39) H163R probably damaging Het
Zfp703 C T 8: 27,469,233 (GRCm39) P299L probably damaging Het
Other mutations in Or5p72
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01448:Or5p72 APN 7 108,022,235 (GRCm39) nonsense probably null
IGL03145:Or5p72 APN 7 108,021,806 (GRCm39) missense probably benign 0.00
R0732:Or5p72 UTSW 7 108,021,784 (GRCm39) missense probably benign 0.00
R1892:Or5p72 UTSW 7 108,022,147 (GRCm39) missense possibly damaging 0.61
R2008:Or5p72 UTSW 7 108,022,389 (GRCm39) missense probably benign 0.01
R3721:Or5p72 UTSW 7 108,022,326 (GRCm39) missense probably damaging 1.00
R4497:Or5p72 UTSW 7 108,022,122 (GRCm39) missense probably benign 0.37
R4674:Or5p72 UTSW 7 108,022,309 (GRCm39) missense possibly damaging 0.65
R4675:Or5p72 UTSW 7 108,022,309 (GRCm39) missense possibly damaging 0.65
R4695:Or5p72 UTSW 7 108,022,196 (GRCm39) missense probably benign 0.18
R5265:Or5p72 UTSW 7 108,022,609 (GRCm39) missense possibly damaging 0.94
R5656:Or5p72 UTSW 7 108,021,825 (GRCm39) missense probably benign 0.03
R6124:Or5p72 UTSW 7 108,022,725 (GRCm39) splice site probably null
R6787:Or5p72 UTSW 7 108,021,889 (GRCm39) missense possibly damaging 0.52
R7174:Or5p72 UTSW 7 108,022,367 (GRCm39) missense probably benign 0.01
R7222:Or5p72 UTSW 7 108,021,844 (GRCm39) missense probably benign 0.00
R7240:Or5p72 UTSW 7 108,022,140 (GRCm39) missense probably damaging 1.00
R8752:Or5p72 UTSW 7 108,022,480 (GRCm39) missense probably benign
R9548:Or5p72 UTSW 7 108,022,416 (GRCm39) missense possibly damaging 0.75
R9786:Or5p72 UTSW 7 108,021,924 (GRCm39) missense probably benign 0.28
Predicted Primers PCR Primer
(F):5'- ACAAAAGTCTGTGTCCAGTTGG -3'
(R):5'- AGACACCACCTTGTTCTGGTC -3'

Sequencing Primer
(F):5'- AAAAGTCTGTGTCCAGTTGGTTGTAG -3'
(R):5'- CTGGACTTGGGCATCACATAAATG -3'
Posted On 2016-11-21