Incidental Mutation 'IGL01115:Zranb2'
| ID |
50756 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zranb2
|
| Ensembl Gene |
ENSMUSG00000028180 |
| Gene Name |
zinc finger, RAN-binding domain containing 2 |
| Synonyms |
Zfp265, Zis, Znf265 |
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
IGL01115
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
3 |
| Chromosomal Location |
157239797-157254047 bp(+) (GRCm39) |
| Type of Mutation |
unclassified |
| DNA Base Change (assembly) |
T to C
at 157252328 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000143533
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000029831]
[ENSMUST00000106057]
[ENSMUST00000106058]
[ENSMUST00000184802]
[ENSMUST00000198915]
|
| AlphaFold |
Q9R020 |
| Predicted Effect |
unknown
Transcript: ENSMUST00000029831
AA Change: S279P
|
| SMART Domains |
Protein: ENSMUSP00000029831
Gene: ENSMUSG00000028180
AA Change: S279P
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_RBZ
|
11 |
35 |
1.02e-2 |
SMART |
|
ZnF_RBZ
|
36 |
54 |
2.09e-1 |
SMART |
|
low complexity region
|
70 |
82 |
N/A |
INTRINSIC |
|
low complexity region
|
108 |
145 |
N/A |
INTRINSIC |
|
low complexity region
|
156 |
293 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000083497
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000106057
|
| SMART Domains |
Protein: ENSMUSP00000101672
Gene: ENSMUSG00000028180
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_RBZ
|
11 |
37 |
1.24e-6 |
SMART |
|
ZnF_RBZ
|
77 |
101 |
3.11e-7 |
SMART |
|
low complexity region
|
117 |
129 |
N/A |
INTRINSIC |
|
low complexity region
|
155 |
192 |
N/A |
INTRINSIC |
|
low complexity region
|
203 |
312 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000106058
AA Change: S316P
|
| SMART Domains |
Protein: ENSMUSP00000101673
Gene: ENSMUSG00000028180
AA Change: S316P
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_RBZ
|
11 |
37 |
1.24e-6 |
SMART |
|
ZnF_RBZ
|
77 |
101 |
3.11e-7 |
SMART |
|
low complexity region
|
117 |
129 |
N/A |
INTRINSIC |
|
low complexity region
|
155 |
192 |
N/A |
INTRINSIC |
|
low complexity region
|
203 |
340 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000106063
AA Change: S193P
|
| SMART Domains |
Protein: ENSMUSP00000101678
Gene: ENSMUSG00000028180
AA Change: S193P
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_RBZ
|
11 |
37 |
8.79e-7 |
SMART |
|
ZnF_RBZ
|
67 |
91 |
3.11e-7 |
SMART |
|
low complexity region
|
107 |
119 |
N/A |
INTRINSIC |
|
low complexity region
|
145 |
182 |
N/A |
INTRINSIC |
|
low complexity region
|
193 |
330 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000152882
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000184802
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000196900
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000198915
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 34 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc10 |
T |
C |
17: 46,621,352 (GRCm39) |
T934A |
probably benign |
Het |
| Ankzf1 |
T |
C |
1: 75,169,259 (GRCm39) |
L55P |
probably damaging |
Het |
| Aoc1 |
T |
C |
6: 48,883,131 (GRCm39) |
S336P |
probably damaging |
Het |
| Bmper |
T |
C |
9: 23,310,985 (GRCm39) |
|
probably benign |
Het |
| Capza2 |
A |
G |
6: 17,654,122 (GRCm39) |
N58S |
probably damaging |
Het |
| Cdca2 |
A |
G |
14: 67,952,146 (GRCm39) |
V75A |
probably damaging |
Het |
| Chmp7 |
A |
G |
14: 69,958,772 (GRCm39) |
S181P |
probably damaging |
Het |
| Colq |
A |
G |
14: 31,267,085 (GRCm39) |
|
probably benign |
Het |
| Dennd5b |
A |
G |
6: 148,911,246 (GRCm39) |
|
probably benign |
Het |
| Has3 |
A |
G |
8: 107,605,320 (GRCm39) |
T509A |
probably benign |
Het |
| Hsh2d |
T |
C |
8: 72,954,463 (GRCm39) |
S282P |
probably damaging |
Het |
| Impg2 |
C |
T |
16: 56,079,803 (GRCm39) |
P536S |
possibly damaging |
Het |
| Naip1 |
T |
A |
13: 100,580,228 (GRCm39) |
|
probably null |
Het |
| Napb |
T |
C |
2: 148,549,089 (GRCm39) |
Y111C |
probably damaging |
Het |
| Or8w1 |
T |
C |
2: 87,465,728 (GRCm39) |
D121G |
probably damaging |
Het |
| Osmr |
A |
G |
15: 6,876,682 (GRCm39) |
|
probably benign |
Het |
| Pcdh10 |
A |
G |
3: 45,347,210 (GRCm39) |
T1002A |
probably damaging |
Het |
| Plcg2 |
T |
C |
8: 118,284,068 (GRCm39) |
W122R |
probably damaging |
Het |
| Prpf19 |
C |
T |
19: 10,877,567 (GRCm39) |
T204M |
probably damaging |
Het |
| Ptbp1 |
T |
A |
10: 79,695,796 (GRCm39) |
|
probably benign |
Het |
| Ptpre |
T |
A |
7: 135,272,493 (GRCm39) |
D402E |
probably damaging |
Het |
| Siglec1 |
T |
C |
2: 130,916,422 (GRCm39) |
N1176S |
probably benign |
Het |
| Son |
A |
G |
16: 91,456,346 (GRCm39) |
T1698A |
probably benign |
Het |
| Spata6l |
T |
C |
19: 28,921,842 (GRCm39) |
|
probably null |
Het |
| Speer2 |
C |
T |
16: 69,658,539 (GRCm39) |
W42* |
probably null |
Het |
| Taf5 |
T |
C |
19: 47,063,521 (GRCm39) |
V357A |
probably benign |
Het |
| Tctn1 |
A |
G |
5: 122,402,270 (GRCm39) |
S55P |
probably benign |
Het |
| Tmem115 |
T |
A |
9: 107,411,781 (GRCm39) |
L35Q |
probably damaging |
Het |
| Tmem30c |
T |
A |
16: 57,096,480 (GRCm39) |
|
probably benign |
Het |
| Tmprss7 |
T |
C |
16: 45,481,152 (GRCm39) |
D678G |
probably damaging |
Het |
| Ugt1a7c |
A |
T |
1: 88,022,967 (GRCm39) |
Q42L |
probably damaging |
Het |
| Unc13b |
T |
A |
4: 43,258,492 (GRCm39) |
V4099E |
probably damaging |
Het |
| Usp36 |
G |
A |
11: 118,176,786 (GRCm39) |
L11F |
probably damaging |
Het |
| Zfp955a |
T |
A |
17: 33,461,554 (GRCm39) |
K193* |
probably null |
Het |
|
| Other mutations in Zranb2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01528:Zranb2
|
APN |
3 |
157,250,602 (GRCm39) |
unclassified |
probably benign |
|
|
IGL03008:Zranb2
|
APN |
3 |
157,252,302 (GRCm39) |
splice site |
probably null |
|
|
R0528:Zranb2
|
UTSW |
3 |
157,240,096 (GRCm39) |
missense |
probably benign |
0.26 |
|
R0659:Zranb2
|
UTSW |
3 |
157,247,400 (GRCm39) |
missense |
probably benign |
0.23 |
|
R1170:Zranb2
|
UTSW |
3 |
157,247,502 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R1673:Zranb2
|
UTSW |
3 |
157,243,277 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1885:Zranb2
|
UTSW |
3 |
157,248,793 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4127:Zranb2
|
UTSW |
3 |
157,243,227 (GRCm39) |
nonsense |
probably null |
|
|
R4610:Zranb2
|
UTSW |
3 |
157,247,521 (GRCm39) |
splice site |
probably benign |
|
|
R4981:Zranb2
|
UTSW |
3 |
157,252,378 (GRCm39) |
unclassified |
probably benign |
|
|
R5053:Zranb2
|
UTSW |
3 |
157,246,796 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5742:Zranb2
|
UTSW |
3 |
157,246,340 (GRCm39) |
nonsense |
probably null |
|
|
R5873:Zranb2
|
UTSW |
3 |
157,242,020 (GRCm39) |
nonsense |
probably null |
|
|
R6086:Zranb2
|
UTSW |
3 |
157,248,883 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7015:Zranb2
|
UTSW |
3 |
157,242,370 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7547:Zranb2
|
UTSW |
3 |
157,246,806 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7579:Zranb2
|
UTSW |
3 |
157,246,309 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8119:Zranb2
|
UTSW |
3 |
157,241,969 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R8237:Zranb2
|
UTSW |
3 |
157,250,677 (GRCm39) |
missense |
probably null |
|
|
R8296:Zranb2
|
UTSW |
3 |
157,247,412 (GRCm39) |
missense |
unknown |
|
|
R8345:Zranb2
|
UTSW |
3 |
157,251,731 (GRCm39) |
missense |
unknown |
|
|
R8414:Zranb2
|
UTSW |
3 |
157,252,312 (GRCm39) |
missense |
unknown |
|
|
R8478:Zranb2
|
UTSW |
3 |
157,251,745 (GRCm39) |
makesense |
probably null |
|
|
R8768:Zranb2
|
UTSW |
3 |
157,247,327 (GRCm39) |
splice site |
probably benign |
|
|
R9021:Zranb2
|
UTSW |
3 |
157,250,720 (GRCm39) |
missense |
unknown |
|
|
| Posted On |
2013-06-21 |
Incidental Mutation