Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01132:Rassf4'

51366

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Rassf4

Ensembl Gene

ENSMUSG00000042129

Gene Name

Ras association (RalGDS/AF-6) domain family member 4

Synonyms

3830411C14Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.075) question?

Stock #

IGL01132

Quality Score

Status

Chromosome

Chromosomal Location

116609969-116650797 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

C to T at 116636568 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000145394 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000035842] [ENSMUST00000203029] [ENSMUST00000204203] [ENSMUST00000204576]

AlphaFold

Q8CB96

Predicted Effect

probably benign
Transcript: ENSMUST00000035842

SMART Domains

Protein: ENSMUSP00000048267
Gene: ENSMUSG00000042129

Domain	Start	End	E-Value	Type
low complexity region	6	16	N/A	INTRINSIC
low complexity region	46	57	N/A	INTRINSIC
RA	173	263	1.36e-15	SMART
Pfam:Nore1-SARAH	276	315	1.7e-15	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000203029

SMART Domains

Protein: ENSMUSP00000144786
Gene: ENSMUSG00000042129

Domain	Start	End	E-Value	Type
low complexity region	6	16	N/A	INTRINSIC
low complexity region	46	57	N/A	INTRINSIC
RA	173	263	8.7e-18	SMART
Pfam:Nore1-SARAH	276	303	1.6e-8	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000204203

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000204313

Predicted Effect

probably benign
Transcript: ENSMUST00000204576

SMART Domains

Protein: ENSMUSP00000145394
Gene: ENSMUSG00000042129

Domain	Start	End	E-Value	Type
low complexity region	3	15	N/A	INTRINSIC
low complexity region	31	42	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The function of this gene has not yet been determined but may involve a role in tumor suppression. Alternative splicing of this gene results in several transcript variants; however, most of the variants have not been fully described. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110038F14Rik	G	A	15: 76,834,475 (GRCm39)	V124I	probably damaging	Het
Adcy6	T	C	15: 98,495,732 (GRCm39)	N619S	probably benign	Het
Adgrf5	G	T	17: 43,733,400 (GRCm39)	D75Y	possibly damaging	Het
Aldh1a7	T	C	19: 20,704,404 (GRCm39)	H30R	possibly damaging	Het
Birc6	T	C	17: 74,910,055 (GRCm39)	S1483P	probably damaging	Het
Cd209e	T	C	8: 3,901,274 (GRCm39)	T127A	probably benign	Het
Clmn	T	A	12: 104,740,810 (GRCm39)		probably null	Het
Dcc	A	T	18: 71,815,245 (GRCm39)	Y376*	probably null	Het
Dennd2b	A	G	7: 109,169,212 (GRCm39)		probably null	Het
Dscaml1	C	T	9: 45,663,626 (GRCm39)	R1950*	probably null	Het
Eml2	A	T	7: 18,934,464 (GRCm39)	S388C	probably damaging	Het
Ext2	C	T	2: 93,621,418 (GRCm39)	M370I	probably benign	Het
Foxo1	C	T	3: 52,252,580 (GRCm39)	R248W	probably damaging	Het
Gan	T	A	8: 117,923,183 (GRCm39)		probably benign	Het
Klra1	A	T	6: 130,341,237 (GRCm39)	C245*	probably null	Het
Myh10	A	T	11: 68,659,094 (GRCm39)	M491L	possibly damaging	Het
Myrf	A	G	19: 10,200,569 (GRCm39)	Y343H	probably damaging	Het
Oplah	C	T	15: 76,185,157 (GRCm39)	S852N	probably benign	Het
Or6c75	T	C	10: 129,337,515 (GRCm39)	V254A	probably damaging	Het
Or7e168	G	A	9: 19,719,950 (GRCm39)	S112N	probably damaging	Het
Or8k37	A	T	2: 86,469,510 (GRCm39)	C181S	probably benign	Het
Prag1	T	C	8: 36,613,511 (GRCm39)	V1021A	probably damaging	Het
Sf3b3	T	C	8: 111,569,413 (GRCm39)	I102V	probably benign	Het
Slc27a4	T	C	2: 29,694,314 (GRCm39)	I46T	probably benign	Het
Slc5a12	T	C	2: 110,428,167 (GRCm39)	V74A	probably damaging	Het
Tas2r134	G	T	2: 51,517,671 (GRCm39)	C50F	probably damaging	Het
Tcte1	G	T	17: 45,850,788 (GRCm39)	A355S	possibly damaging	Het

Other mutations in Rassf4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00482:Rassf4	APN	6	116,622,089 (GRCm39)	missense	possibly damaging	0.47
IGL01637:Rassf4	APN	6	116,618,651 (GRCm39)	missense	probably damaging	1.00
IGL02000:Rassf4	APN	6	116,622,933 (GRCm39)	missense	probably benign	0.20
IGL02748:Rassf4	APN	6	116,616,418 (GRCm39)	missense	possibly damaging	0.93
IGL02976:Rassf4	APN	6	116,615,209 (GRCm39)	missense	probably damaging	0.96
IGL03394:Rassf4	APN	6	116,618,708 (GRCm39)	missense	probably damaging	1.00
R0573:Rassf4	UTSW	6	116,624,516 (GRCm39)	splice site	probably benign
R0599:Rassf4	UTSW	6	116,622,897 (GRCm39)	missense	probably damaging	1.00
R1741:Rassf4	UTSW	6	116,616,450 (GRCm39)	missense	probably damaging	1.00
R1750:Rassf4	UTSW	6	116,617,228 (GRCm39)	missense	probably damaging	1.00
R2117:Rassf4	UTSW	6	116,622,088 (GRCm39)	missense	possibly damaging	0.86
R2369:Rassf4	UTSW	6	116,615,258 (GRCm39)	missense	probably damaging	0.97
R2916:Rassf4	UTSW	6	116,618,701 (GRCm39)	missense	probably damaging	1.00
R2918:Rassf4	UTSW	6	116,618,701 (GRCm39)	missense	probably damaging	1.00
R4829:Rassf4	UTSW	6	116,622,103 (GRCm39)	missense	possibly damaging	0.80
R5716:Rassf4	UTSW	6	116,638,828 (GRCm39)	missense	probably benign	0.01
R6769:Rassf4	UTSW	6	116,618,433 (GRCm39)	missense	possibly damaging	0.95
R7304:Rassf4	UTSW	6	116,617,278 (GRCm39)	missense	probably damaging	0.99
R7981:Rassf4	UTSW	6	116,617,218 (GRCm39)	missense	probably damaging	1.00
R8890:Rassf4	UTSW	6	116,617,305 (GRCm39)	missense	probably damaging	1.00
R8921:Rassf4	UTSW	6	116,638,897 (GRCm39)	splice site	probably benign
R9459:Rassf4	UTSW	6	116,618,749 (GRCm39)	critical splice acceptor site	probably null
R9516:Rassf4	UTSW	6	116,617,265 (GRCm39)	missense	possibly damaging	0.89
R9698:Rassf4	UTSW	6	116,618,662 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-06-21