Incidental Mutation 'IGL01095:Rasd1'
ID 52275
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Rasd1
Ensembl Gene ENSMUSG00000049892
Gene Name RAS, dexamethasone-induced 1
Synonyms Dexras1
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01095
Quality Score
Status
Chromosome 11
Chromosomal Location 59854007-59855770 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 59855117 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 121 (I121T)
Ref Sequence ENSEMBL: ENSMUSP00000051959 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062405] [ENSMUST00000081980]
AlphaFold O35626
Predicted Effect probably damaging
Transcript: ENSMUST00000062405
AA Change: I121T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000051959
Gene: ENSMUSG00000049892
AA Change: I121T

DomainStartEndE-ValueType
RAS 22 198 4.81e-81 SMART
low complexity region 217 243 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000081980
SMART Domains Protein: ENSMUSP00000080641
Gene: ENSMUSG00000061650

DomainStartEndE-ValueType
low complexity region 16 52 N/A INTRINSIC
Pfam:Med9 59 135 3.2e-27 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. [provided by RefSeq, Nov 2015]
PHENOTYPE: Mice homozygous for disruptions in this gene have a reduced ability to entrain to low intensity light with resulting abnormalities in circadian rhythm. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam34l T A 8: 44,079,133 (GRCm39) I364L probably benign Het
Adgra1 A G 7: 139,425,570 (GRCm39) T28A possibly damaging Het
Aldh8a1 A G 10: 21,265,180 (GRCm39) E269G probably benign Het
Alkbh7 A G 17: 57,304,470 (GRCm39) probably null Het
Ap1g2 T C 14: 55,342,571 (GRCm39) T129A probably benign Het
Ap1s1 A G 5: 137,070,663 (GRCm39) I117T probably damaging Het
Brca1 G A 11: 101,415,195 (GRCm39) P119S possibly damaging Het
Chid1 A G 7: 141,110,142 (GRCm39) V62A probably damaging Het
Cpa1 A T 6: 30,642,968 (GRCm39) I299F probably benign Het
Cuzd1 A G 7: 130,917,865 (GRCm39) V245A probably damaging Het
Ddx39b T C 17: 35,465,937 (GRCm39) S71P probably benign Het
Ddx42 A G 11: 106,138,325 (GRCm39) Y708C probably damaging Het
Dnah3 C A 7: 119,550,820 (GRCm39) L3166F probably benign Het
Erap1 A G 13: 74,816,213 (GRCm39) E114G probably benign Het
Fap G A 2: 62,354,545 (GRCm39) T448I possibly damaging Het
Fhl2 A T 1: 43,170,841 (GRCm39) Y158N probably benign Het
Fscb A G 12: 64,520,155 (GRCm39) V437A possibly damaging Het
Il18 A T 9: 50,490,629 (GRCm39) D88V probably damaging Het
Il5ra A T 6: 106,719,605 (GRCm39) probably benign Het
Jakmip3 A T 7: 138,622,546 (GRCm39) Q302L probably damaging Het
Lrp2 A T 2: 69,322,776 (GRCm39) Y1857* probably null Het
Meis2 T C 2: 115,694,905 (GRCm39) T406A probably benign Het
Mre11a T A 9: 14,721,120 (GRCm39) S346R probably benign Het
Myh15 A T 16: 48,952,378 (GRCm39) K816M probably damaging Het
Mysm1 C T 4: 94,856,106 (GRCm39) probably null Het
Nyap1 C A 5: 137,736,346 (GRCm39) R47L probably damaging Het
Oas3 A G 5: 120,910,954 (GRCm39) Y209H probably damaging Het
Or2v2 T G 11: 49,003,680 (GRCm39) Y291S probably damaging Het
Or4g16 A G 2: 111,136,966 (GRCm39) R139G probably benign Het
Or6c209 A G 10: 129,483,498 (GRCm39) D167G probably benign Het
Or8b42 A G 9: 38,341,811 (GRCm39) I78V probably benign Het
Or8d6 T C 9: 39,853,976 (GRCm39) V140A probably benign Het
Pde4b T C 4: 102,363,241 (GRCm39) probably null Het
Psd3 G A 8: 68,361,165 (GRCm39) T99M probably damaging Het
R3hcc1 T C 14: 69,937,477 (GRCm39) E390G probably damaging Het
Rabgap1l A C 1: 160,566,539 (GRCm39) C58W probably benign Het
Spta1 A G 1: 174,041,051 (GRCm39) N1284D probably benign Het
Tpr T C 1: 150,285,891 (GRCm39) V525A possibly damaging Het
Other mutations in Rasd1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02206:Rasd1 APN 11 59,854,778 (GRCm39) missense possibly damaging 0.69
IGL02534:Rasd1 APN 11 59,855,615 (GRCm39) missense possibly damaging 0.86
IGL03306:Rasd1 APN 11 59,855,181 (GRCm39) missense possibly damaging 0.64
R0833:Rasd1 UTSW 11 59,855,379 (GRCm39) missense probably damaging 1.00
R0836:Rasd1 UTSW 11 59,855,379 (GRCm39) missense probably damaging 1.00
R1160:Rasd1 UTSW 11 59,855,547 (GRCm39) missense possibly damaging 0.78
R1647:Rasd1 UTSW 11 59,854,920 (GRCm39) missense probably benign 0.26
R5114:Rasd1 UTSW 11 59,854,933 (GRCm39) missense possibly damaging 0.69
R8234:Rasd1 UTSW 11 59,855,118 (GRCm39) missense probably damaging 1.00
Posted On 2013-06-21