Incidental Mutation 'R6604:Zfp958'
| ID |
525543 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp958
|
| Ensembl Gene |
ENSMUSG00000058748 |
| Gene Name |
zinc finger protein 958 |
| Synonyms |
BC003267 |
| MMRRC Submission |
044727-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.080)
|
| Stock # |
R6604 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
8 |
| Chromosomal Location |
4663167-4680231 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 4678245 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Proline
at position 90
(L90P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000143842
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000073201]
[ENSMUST00000202692]
|
| AlphaFold |
Q99LG7 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000073201
AA Change: L89P
PolyPhen 2
Score 0.112 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000072937
Gene: ENSMUSG00000058748
AA Change: L89P
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
3 |
65 |
1.96e-17 |
SMART |
|
ZnF_C2H2
|
102 |
124 |
2.67e-1 |
SMART |
|
ZnF_C2H2
|
130 |
152 |
8.47e-4 |
SMART |
|
ZnF_C2H2
|
158 |
180 |
5.5e-3 |
SMART |
|
ZnF_C2H2
|
186 |
208 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
214 |
236 |
9.96e-1 |
SMART |
|
ZnF_C2H2
|
242 |
264 |
2.15e-5 |
SMART |
|
ZnF_C2H2
|
270 |
292 |
3.16e-3 |
SMART |
|
ZnF_C2H2
|
298 |
320 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
326 |
348 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
354 |
376 |
2.91e-2 |
SMART |
|
ZnF_C2H2
|
382 |
404 |
2.27e-4 |
SMART |
|
ZnF_C2H2
|
410 |
432 |
4.79e-3 |
SMART |
|
ZnF_C2H2
|
438 |
460 |
6.88e-4 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000202692
AA Change: L90P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000143842
Gene: ENSMUSG00000058748
AA Change: L90P
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
66 |
1.96e-17 |
SMART |
|
ZnF_C2H2
|
103 |
125 |
2.67e-1 |
SMART |
|
ZnF_C2H2
|
131 |
153 |
8.47e-4 |
SMART |
|
ZnF_C2H2
|
159 |
181 |
5.5e-3 |
SMART |
|
ZnF_C2H2
|
187 |
209 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
215 |
237 |
9.96e-1 |
SMART |
|
ZnF_C2H2
|
243 |
265 |
2.15e-5 |
SMART |
|
ZnF_C2H2
|
271 |
293 |
3.16e-3 |
SMART |
|
ZnF_C2H2
|
299 |
321 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
327 |
349 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
355 |
377 |
2.91e-2 |
SMART |
|
ZnF_C2H2
|
383 |
405 |
2.27e-4 |
SMART |
|
ZnF_C2H2
|
411 |
433 |
4.79e-3 |
SMART |
|
ZnF_C2H2
|
439 |
461 |
6.88e-4 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.1%
- 20x: 94.4%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 33 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930447A16Rik |
A |
G |
15: 37,439,823 (GRCm39) |
|
probably benign |
Het |
| Abca13 |
T |
G |
11: 9,328,384 (GRCm39) |
F3486V |
probably damaging |
Het |
| Adcy9 |
A |
G |
16: 4,122,271 (GRCm39) |
L830P |
probably damaging |
Het |
| Aurkb |
T |
A |
11: 68,939,388 (GRCm39) |
L157* |
probably null |
Het |
| Bbs10 |
T |
G |
10: 111,136,965 (GRCm39) |
L693V |
possibly damaging |
Het |
| Dna2 |
G |
T |
10: 62,803,522 (GRCm39) |
|
probably null |
Het |
| Efcab3 |
T |
A |
11: 104,589,772 (GRCm39) |
L123* |
probably null |
Het |
| Ext1 |
A |
G |
15: 52,946,555 (GRCm39) |
F550L |
probably damaging |
Het |
| Gm5129 |
A |
G |
5: 29,940,765 (GRCm39) |
|
probably benign |
Het |
| Golm1 |
A |
G |
13: 59,786,197 (GRCm39) |
Y332H |
probably damaging |
Het |
| Gpbp1l1 |
C |
T |
4: 116,430,702 (GRCm39) |
P58S |
probably benign |
Het |
| Grk4 |
A |
T |
5: 34,877,208 (GRCm39) |
D301V |
probably damaging |
Het |
| Haus1 |
T |
C |
18: 77,851,797 (GRCm39) |
E106G |
probably damaging |
Het |
| Hpd |
T |
C |
5: 123,318,964 (GRCm39) |
|
probably null |
Het |
| Kcnj6 |
C |
A |
16: 94,563,504 (GRCm39) |
E313D |
probably damaging |
Het |
| Lmna |
A |
G |
3: 88,395,589 (GRCm39) |
V57A |
probably damaging |
Het |
| Lrrtm1 |
T |
C |
6: 77,221,221 (GRCm39) |
F226S |
possibly damaging |
Het |
| Otogl |
T |
C |
10: 107,657,895 (GRCm39) |
|
probably null |
Het |
| Pgr |
A |
C |
9: 8,946,867 (GRCm39) |
T703P |
possibly damaging |
Het |
| Ppig |
T |
C |
2: 69,571,925 (GRCm39) |
S215P |
unknown |
Het |
| Pramel28 |
T |
C |
4: 143,692,567 (GRCm39) |
R145G |
probably benign |
Het |
| Rasgrp3 |
A |
C |
17: 75,810,110 (GRCm39) |
N270T |
probably benign |
Het |
| Rp1 |
C |
A |
1: 4,089,351 (GRCm39) |
K1305N |
unknown |
Het |
| Shc1 |
A |
G |
3: 89,329,186 (GRCm39) |
Y10C |
probably damaging |
Het |
| Slc12a1 |
G |
T |
2: 125,026,735 (GRCm39) |
D457Y |
probably damaging |
Het |
| Sncaip |
A |
G |
18: 53,038,918 (GRCm39) |
Q544R |
possibly damaging |
Het |
| Socs5 |
T |
C |
17: 87,442,553 (GRCm39) |
Y498H |
probably damaging |
Het |
| Szt2 |
T |
C |
4: 118,242,671 (GRCm39) |
D1472G |
probably benign |
Het |
| Tmem163 |
A |
G |
1: 127,419,347 (GRCm39) |
M286T |
possibly damaging |
Het |
| Tmem236 |
A |
G |
2: 14,179,512 (GRCm39) |
T38A |
probably benign |
Het |
| Vmn2r29 |
A |
T |
7: 7,234,858 (GRCm39) |
V676E |
probably damaging |
Het |
| Vps13d |
A |
G |
4: 144,907,694 (GRCm39) |
V56A |
probably damaging |
Het |
| Xirp2 |
T |
C |
2: 67,340,189 (GRCm39) |
I810T |
possibly damaging |
Het |
|
| Other mutations in Zfp958 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01950:Zfp958
|
APN |
8 |
4,678,917 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02185:Zfp958
|
APN |
8 |
4,678,990 (GRCm39) |
nonsense |
probably null |
|
|
IGL02716:Zfp958
|
APN |
8 |
4,675,967 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1118:Zfp958
|
UTSW |
8 |
4,676,169 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R1119:Zfp958
|
UTSW |
8 |
4,676,169 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R1478:Zfp958
|
UTSW |
8 |
4,679,190 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1816:Zfp958
|
UTSW |
8 |
4,679,147 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R1837:Zfp958
|
UTSW |
8 |
4,678,590 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1838:Zfp958
|
UTSW |
8 |
4,678,590 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3763:Zfp958
|
UTSW |
8 |
4,676,226 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5257:Zfp958
|
UTSW |
8 |
4,678,456 (GRCm39) |
missense |
probably benign |
0.28 |
|
R5258:Zfp958
|
UTSW |
8 |
4,678,456 (GRCm39) |
missense |
probably benign |
0.28 |
|
R5304:Zfp958
|
UTSW |
8 |
4,676,196 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R5512:Zfp958
|
UTSW |
8 |
4,675,838 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5907:Zfp958
|
UTSW |
8 |
4,679,072 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6688:Zfp958
|
UTSW |
8 |
4,678,940 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6727:Zfp958
|
UTSW |
8 |
4,678,247 (GRCm39) |
missense |
probably benign |
0.08 |
|
R6981:Zfp958
|
UTSW |
8 |
4,676,170 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7010:Zfp958
|
UTSW |
8 |
4,678,377 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7140:Zfp958
|
UTSW |
8 |
4,678,481 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8096:Zfp958
|
UTSW |
8 |
4,663,273 (GRCm39) |
start gained |
probably benign |
|
|
R8491:Zfp958
|
UTSW |
8 |
4,676,215 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8673:Zfp958
|
UTSW |
8 |
4,678,268 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R8847:Zfp958
|
UTSW |
8 |
4,678,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9612:Zfp958
|
UTSW |
8 |
4,678,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATGCAATCAGTGTGGTAAGGT -3'
(R):5'- TGTGCAAAGGCTTTACCACATT -3'
Sequencing Primer
(F):5'- CAATCAGTGTGGTAAGGTTCTAAG -3'
(R):5'- GCAAAGGCTTTACCACATTGATTAC -3'
|
| Posted On |
2018-06-22 |
Incidental Mutation