Mutagenetix > Incidental Mutation

Incidental Mutation 'R6689:Commd6'

527893

Institutional Source

Beutler Lab

Gene Symbol

Commd6

Ensembl Gene

ENSMUSG00000075486

Gene Name

COMM domain containing 6

Synonyms

1110059J08Rik, 1700063H17Rik

MMRRC Submission

044807-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.136) question?

Stock #

R6689 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

101871202-101877907 bp(-) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

C to A at 101877895 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000131634 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000100339] [ENSMUST00000168587]

AlphaFold

Q3V4B5

Predicted Effect

probably benign
Transcript: ENSMUST00000100339

SMART Domains

Protein: ENSMUSP00000097912
Gene: ENSMUSG00000075486

Domain	Start	End	E-Value	Type
Pfam:HCaRG	7	86	6.4e-18	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000131022

Predicted Effect

probably benign
Transcript: ENSMUST00000168587

SMART Domains

Protein: ENSMUSP00000131634
Gene: ENSMUSG00000075486

Domain	Start	End	E-Value	Type
Pfam:HCaRG	5	83	3.3e-18	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000227868

Coding Region Coverage

1x: 99.9%
3x: 99.7%
10x: 98.6%
20x: 96.2%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 16 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ankk1	T	A	9: 49,331,776 (GRCm39)	I173F	probably damaging	Het
Aurka	A	G	2: 172,212,313 (GRCm39)		probably null	Het
B4galnt4	C	T	7: 140,647,897 (GRCm39)	T471I	probably benign	Het
Ccn1	T	A	3: 145,353,543 (GRCm39)	M340L	probably benign	Het
Elobl	T	C	11: 88,855,919 (GRCm39)	N48S	possibly damaging	Het
Grem1	T	C	2: 113,580,276 (GRCm39)	E75G	probably benign	Het
Hp	C	T	8: 110,302,352 (GRCm39)	V199I	probably benign	Het
Kcna2	C	A	3: 107,012,343 (GRCm39)	S308Y	probably damaging	Het
Lgr5	T	A	10: 115,302,513 (GRCm39)	I293F	probably damaging	Het
Lmln	A	G	16: 32,925,152 (GRCm39)	R462G	probably benign	Het
Lsm3	GATATATA	GATATATATA	6: 91,496,617 (GRCm39)		probably null	Het
Mroh4	A	G	15: 74,483,852 (GRCm39)	V495A	probably damaging	Het
Or10c1	C	G	17: 37,522,048 (GRCm39)	G232A	probably damaging	Het
Or8h10	A	G	2: 86,808,498 (GRCm39)	I214T	probably benign	Het
Spmip4	A	G	6: 50,566,089 (GRCm39)		probably null	Het
Stim2	G	A	5: 54,273,318 (GRCm39)	R524H	probably damaging	Het

Other mutations in Commd6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01324:Commd6	APN	14	101,877,738 (GRCm39)	intron	probably benign
IGL02469:Commd6	APN	14	101,874,463 (GRCm39)	missense	probably damaging	1.00
IGL03405:Commd6	APN	14	101,874,508 (GRCm39)	missense	probably damaging	1.00
R0008:Commd6	UTSW	14	101,877,709 (GRCm39)	intron	probably benign
R4676:Commd6	UTSW	14	101,877,720 (GRCm39)	intron	probably benign
R6841:Commd6	UTSW	14	101,874,534 (GRCm39)	missense	probably damaging	1.00
R6875:Commd6	UTSW	14	101,871,786 (GRCm39)	missense	probably damaging	0.98
R6983:Commd6	UTSW	14	101,874,488 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GCAGTTTAAGTGACAGCCAC -3'
(R):5'- ATCCTGGATGTCACGAGTCC -3'

Sequencing Primer
(F):5'- ATCCCCTCGGGTGCAAGAG -3'
(R):5'- TGGATGTCACGAGTCCTCCAC -3'

Posted On

2018-07-23