Incidental Mutation 'R6844:Sst'
ID 534690
Institutional Source Beutler Lab
Gene Symbol Sst
Ensembl Gene ENSMUSG00000004366
Gene Name somatostatin
Synonyms Smst, preprosomatostatin, SRIF, SOM
MMRRC Submission 044950-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6844 (G1)
Quality Score 225.009
Status Validated
Chromosome 16
Chromosomal Location 23708323-23709708 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 23708592 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Asparagine at position 80 (D80N)
Ref Sequence ENSEMBL: ENSMUSP00000004480 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000004480]
AlphaFold P60041
Predicted Effect probably benign
Transcript: ENSMUST00000004480
AA Change: D80N

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000004480
Gene: ENSMUSG00000004366
AA Change: D80N

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:Somatostatin 99 116 5.9e-15 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.2%
Validation Efficiency 92% (36/39)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele show altered GH secretory dynamics, hypergastremia, and reduced hippocampal bursting and excitatory transmission. Mice homozygous for another null allele show impaired motor learning, higher GH and corticosterone levels,gastric fundus hyperplasia and hyperacidity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap18 G A 10: 26,648,682 (GRCm39) A35T probably benign Het
Arhgap21 A G 2: 20,886,116 (GRCm39) S354P probably benign Het
Casq2 A T 3: 102,017,578 (GRCm39) H86L possibly damaging Het
Ccdc188 G A 16: 18,036,074 (GRCm39) G83E probably damaging Het
Cd22 G T 7: 30,572,856 (GRCm39) probably null Het
Cyp2b13 T A 7: 25,781,122 (GRCm39) I178N probably damaging Het
Cyp4a31 T A 4: 115,420,989 (GRCm39) C26S probably null Het
Eif3h T C 15: 51,728,729 (GRCm39) D42G possibly damaging Het
Elovl4 T A 9: 83,672,164 (GRCm39) I52L probably benign Het
Fgfbp3 C A 19: 36,896,280 (GRCm39) A113S possibly damaging Het
Fsip2 A T 2: 82,813,969 (GRCm39) K3429N possibly damaging Het
Gemin5 T C 11: 58,054,730 (GRCm39) D224G probably benign Het
Gm3415 T C 5: 146,494,811 (GRCm39) I158T probably benign Het
Gpr22 C A 12: 31,759,951 (GRCm39) R20L probably benign Het
Htr1a A G 13: 105,581,455 (GRCm39) K232E possibly damaging Het
Itgax T A 7: 127,747,106 (GRCm39) probably null Het
Jag2 T C 12: 112,880,334 (GRCm39) Y310C probably damaging Het
Lce1j A G 3: 92,696,656 (GRCm39) S41P unknown Het
Mllt10 A G 2: 18,164,294 (GRCm39) I197V probably benign Het
Muc5ac C T 7: 141,363,481 (GRCm39) probably benign Het
Mybpc1 T A 10: 88,372,243 (GRCm39) I796F possibly damaging Het
Nr2c1 T A 10: 94,007,029 (GRCm39) L289* probably null Het
Omp T A 7: 97,794,283 (GRCm39) M115L probably benign Het
Pdcd1 C T 1: 93,967,106 (GRCm39) R264H probably benign Het
Plxna2 T C 1: 194,476,136 (GRCm39) F1119L probably benign Het
Ralyl A G 3: 13,841,938 (GRCm39) T25A probably damaging Het
Rapgef4 A G 2: 72,064,970 (GRCm39) T656A probably damaging Het
Ripor3 C T 2: 167,835,253 (GRCm39) probably null Het
Samd8 T C 14: 21,825,205 (GRCm39) S54P probably damaging Het
Serpinb9g A T 13: 33,670,616 (GRCm39) I35F probably damaging Het
Shisa8 T C 15: 82,096,310 (GRCm39) S102G probably damaging Het
Slc4a1ap T A 5: 31,684,822 (GRCm39) S153T probably damaging Het
Slc4a4 T A 5: 89,376,831 (GRCm39) D1028E probably damaging Het
Slc6a13 T A 6: 121,302,012 (GRCm39) I198N probably damaging Het
Synj2 A G 17: 6,026,081 (GRCm39) K47E probably damaging Het
Tal1 C T 4: 114,920,464 (GRCm39) P46L probably benign Het
Top2b A T 14: 16,429,383 (GRCm38) N1541I possibly damaging Het
Vps13b T A 15: 35,877,736 (GRCm39) N2903K probably benign Het
Zfp949 A G 9: 88,451,464 (GRCm39) T345A possibly damaging Het
Zmat3 A G 3: 32,395,644 (GRCm39) Y288H probably damaging Het
Other mutations in Sst
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1472:Sst UTSW 16 23,709,448 (GRCm39) missense probably benign
R1853:Sst UTSW 16 23,709,403 (GRCm39) missense probably damaging 1.00
R2209:Sst UTSW 16 23,708,558 (GRCm39) missense probably benign 0.05
R3919:Sst UTSW 16 23,708,591 (GRCm39) missense possibly damaging 0.59
R4350:Sst UTSW 16 23,708,565 (GRCm39) missense probably damaging 0.99
R4351:Sst UTSW 16 23,708,565 (GRCm39) missense probably damaging 0.99
R4352:Sst UTSW 16 23,708,565 (GRCm39) missense probably damaging 0.99
R5586:Sst UTSW 16 23,708,487 (GRCm39) missense probably damaging 1.00
R7492:Sst UTSW 16 23,708,576 (GRCm39) missense probably damaging 1.00
R8903:Sst UTSW 16 23,708,499 (GRCm39) nonsense probably null
R9417:Sst UTSW 16 23,708,487 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGGGTCAAGTTGAGCATCGG -3'
(R):5'- CACCCATATGATTGTGAAAACTGGG -3'

Sequencing Primer
(F):5'- AAGTTGAGCATCGGGGGCC -3'
(R):5'- CATATGATTGTGAAAACTGGGTTTTG -3'
Posted On 2018-09-12