Incidental Mutation 'IGL01357:Fev'
ID 75579
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fev
Ensembl Gene ENSMUSG00000055197
Gene Name FEV transcription factor, ETS family member
Synonyms Pet1, mPet-1, Pex1
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.339) question?
Stock # IGL01357
Quality Score
Status
Chromosome 1
Chromosomal Location 74920668-74924578 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 74921683 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 89 (E89G)
Ref Sequence ENSEMBL: ENSMUSP00000070878 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068631] [ENSMUST00000159232]
AlphaFold Q8QZW2
Predicted Effect possibly damaging
Transcript: ENSMUST00000068631
AA Change: E89G

PolyPhen 2 Score 0.923 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000070878
Gene: ENSMUSG00000055197
AA Change: E89G

DomainStartEndE-ValueType
ETS 46 131 2.44e-57 SMART
low complexity region 132 156 N/A INTRINSIC
low complexity region 163 175 N/A INTRINSIC
low complexity region 200 209 N/A INTRINSIC
low complexity region 212 229 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000159232
SMART Domains Protein: ENSMUSP00000125067
Gene: ENSMUSG00000055197

DomainStartEndE-ValueType
ETS 1 36 5.19e-3 SMART
low complexity region 37 61 N/A INTRINSIC
low complexity region 68 80 N/A INTRINSIC
low complexity region 105 114 N/A INTRINSIC
low complexity region 117 134 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159627
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162938
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor. This gene is exclusively expressed in neurons of the central serotonin (5-HT) system, a system implicated in the pathogeny of such psychiatric diseases as depression, anxiety, and eating disorders. In some types of Ewing tumors, this gene is fused to the Ewing sarcoma (EWS) gene following chromosome translocations. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous inactivation of this gene leads to partial lethality within the first week of life, causes impaired serotonergic neuron development, and results in increased anxiety-like and aggressive behavior in adulthood. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310022B05Rik C A 8: 125,366,072 (GRCm39) V224F probably damaging Het
Abca4 T A 3: 121,897,232 (GRCm39) M637K probably damaging Het
Abca8a A G 11: 109,922,398 (GRCm39) V1395A probably benign Het
Adam20 A C 8: 41,249,597 (GRCm39) D569A probably benign Het
Axl A G 7: 25,473,594 (GRCm39) L344P probably benign Het
B3gat1 T C 9: 26,668,283 (GRCm39) L291P probably damaging Het
Cdc25c A T 18: 34,867,910 (GRCm39) probably null Het
Crat A T 2: 30,297,736 (GRCm39) Y263N probably damaging Het
Crb2 A G 2: 37,685,523 (GRCm39) probably benign Het
Dhx33 G A 11: 70,884,687 (GRCm39) Q40* probably null Het
Dnah7a A T 1: 53,701,540 (GRCm39) V205D probably benign Het
Emsy A T 7: 98,240,077 (GRCm39) Y1011* probably null Het
Fbln5 C T 12: 101,717,146 (GRCm39) S414N probably damaging Het
Fgg A G 3: 82,921,535 (GRCm39) E406G possibly damaging Het
Glra1 A T 11: 55,405,715 (GRCm39) M425K possibly damaging Het
Gm8214 C T 1: 183,414,129 (GRCm39) noncoding transcript Het
Kdm3b A G 18: 34,926,067 (GRCm39) E69G probably damaging Het
Kntc1 T A 5: 123,895,877 (GRCm39) V89E probably damaging Het
L3mbtl3 T A 10: 26,206,083 (GRCm39) N361I unknown Het
Macrod2 A G 2: 142,226,250 (GRCm39) N457S probably damaging Het
Mal C A 2: 127,482,234 (GRCm39) M56I probably damaging Het
Mfsd5 C T 15: 102,189,882 (GRCm39) T418M probably benign Het
Mmaa C A 8: 79,994,600 (GRCm39) R402L probably benign Het
Myo15a T C 11: 60,393,115 (GRCm39) probably benign Het
Nme1 A G 11: 93,850,317 (GRCm39) S122P possibly damaging Het
Nxt1 A G 2: 148,517,316 (GRCm39) E19G probably damaging Het
Nynrin A T 14: 56,107,874 (GRCm39) T994S probably benign Het
Orc2 T G 1: 58,536,551 (GRCm39) E56D probably benign Het
Orc2 T C 1: 58,536,552 (GRCm39) E56G probably benign Het
Pid1 G A 1: 84,016,026 (GRCm39) T113I probably damaging Het
Plcg2 G A 8: 118,340,900 (GRCm39) probably benign Het
Rad50 A G 11: 53,597,848 (GRCm39) V12A probably damaging Het
Serpinb9c C T 13: 33,335,862 (GRCm39) V197I probably benign Het
Sfxn2 A T 19: 46,574,212 (GRCm39) N134I probably damaging Het
Spen T C 4: 141,244,424 (GRCm39) R204G unknown Het
Strip2 A G 6: 29,939,166 (GRCm39) probably benign Het
Tas2r135 A T 6: 42,383,078 (GRCm39) I206L probably benign Het
Tmem243 A G 5: 9,151,348 (GRCm39) T11A probably damaging Het
Tmprss11c A G 5: 86,379,666 (GRCm39) V401A probably damaging Het
Trim50 T A 5: 135,392,808 (GRCm39) I241N probably damaging Het
Ttn A C 2: 76,781,864 (GRCm39) S1015A possibly damaging Het
Wee1 T C 7: 109,741,242 (GRCm39) S622P probably benign Het
Other mutations in Fev
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0521:Fev UTSW 1 74,921,692 (GRCm39) missense possibly damaging 0.71
R5395:Fev UTSW 1 74,921,823 (GRCm39) critical splice acceptor site probably null
R6178:Fev UTSW 1 74,923,698 (GRCm39) intron probably benign
R6962:Fev UTSW 1 74,921,299 (GRCm39) missense probably benign 0.33
R7934:Fev UTSW 1 74,921,632 (GRCm39) missense probably damaging 1.00
R8707:Fev UTSW 1 74,924,316 (GRCm39) critical splice donor site probably null
Posted On 2013-10-07