Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01403:Or5p55'

79694

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or5p55

Ensembl Gene

ENSMUSG00000095301

Gene Name

olfactory receptor family 5 subfamily P member 55

Synonyms

GA_x6K02T2PBJ9-10296787-10297719, Olfr476, MOR204-3

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

IGL01403

Quality Score

Status

Chromosome

Chromosomal Location

107566606-107567538 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 107566828 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 75 (T75A)

Ref Sequence

ENSEMBL: ENSMUSP00000149760 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077249] [ENSMUST00000217173]

AlphaFold

Q8VGI4

Predicted Effect

possibly damaging
Transcript: ENSMUST00000077249
AA Change: T75A

PolyPhen 2 Score 0.643 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000076485
Gene: ENSMUSG00000095301
AA Change: T75A

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	1.7e-51	PFAM
Pfam:7tm_1	41	290	4.1e-19	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000217173
AA Change: T75A

PolyPhen 2 Score 0.643 (Sensitivity: 0.87; Specificity: 0.91)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb5	A	T	12: 118,836,602 (GRCm39)	L1103Q	probably damaging	Het
Adam12	T	A	7: 133,521,339 (GRCm39)	Q605L	probably benign	Het
Adk	A	G	14: 21,284,983 (GRCm39)	K102R	probably damaging	Het
Afdn	C	T	17: 14,124,132 (GRCm39)	P1761S	probably damaging	Het
Ascc1	A	G	10: 59,848,280 (GRCm39)		probably benign	Het
Aspdh	A	G	7: 44,115,983 (GRCm39)		probably null	Het
Bbx	T	C	16: 50,022,876 (GRCm39)	I753V	probably benign	Het
Ccdc33	T	C	9: 58,024,668 (GRCm39)	Y186C	probably damaging	Het
Ccdc78	T	A	17: 26,007,218 (GRCm39)		probably null	Het
Ckmt1	T	C	2: 121,193,447 (GRCm39)		probably benign	Het
Csf1r	A	G	18: 61,247,897 (GRCm39)	T322A	probably benign	Het
Dnah7b	T	C	1: 46,155,460 (GRCm39)		probably benign	Het
Dr1	A	G	5: 108,417,576 (GRCm39)	N41D	possibly damaging	Het
Ehmt1	G	A	2: 24,729,638 (GRCm39)	T633I	possibly damaging	Het
Fgf7	T	A	2: 125,877,860 (GRCm39)	Y76N	probably damaging	Het
Hmcn1	A	T	1: 150,468,848 (GRCm39)	W5038R	probably damaging	Het
Ighv14-1	A	G	12: 113,895,862 (GRCm39)	V21A	probably damaging	Het
Igkv5-37	T	A	6: 69,940,420 (GRCm39)	I75F	probably damaging	Het
Inhbc	T	A	10: 127,205,968 (GRCm39)	I100F	probably damaging	Het
Irs3	A	G	5: 137,643,581 (GRCm39)	F68L	probably damaging	Het
Itpr3	T	A	17: 27,337,569 (GRCm39)	C2460S	probably damaging	Het
Krt34	A	G	11: 99,929,116 (GRCm39)	C365R	possibly damaging	Het
Krt81	G	A	15: 101,361,269 (GRCm39)	H104Y	probably benign	Het
Ly6g	A	G	15: 75,030,497 (GRCm39)	N82S	probably damaging	Het
Mrpl58	A	T	11: 115,297,404 (GRCm39)	I72F	probably damaging	Het
Myo9a	G	A	9: 59,778,846 (GRCm39)	R1534H	probably damaging	Het
Npat	T	A	9: 53,466,429 (GRCm39)	F239L	probably benign	Het
Nsd2	A	G	5: 34,042,722 (GRCm39)		probably benign	Het
Nuggc	T	C	14: 65,860,635 (GRCm39)	V427A	probably benign	Het
Or52b1	G	A	7: 104,978,605 (GRCm39)	R265C	probably benign	Het
Pde4a	A	T	9: 21,116,412 (GRCm39)	I467F	probably damaging	Het
Pkhd1l1	T	A	15: 44,347,229 (GRCm39)	C198*	probably null	Het
Pla2r1	A	G	2: 60,254,632 (GRCm39)	V1312A	probably damaging	Het
Pola2	T	C	19: 6,009,121 (GRCm39)	H79R	probably benign	Het
Potefam1	T	C	2: 111,059,515 (GRCm39)		probably benign	Het
Pramel15	A	T	4: 144,103,703 (GRCm39)	M141K	probably benign	Het
Psen2	A	T	1: 180,062,548 (GRCm39)		probably benign	Het
Rnf213	A	G	11: 119,334,126 (GRCm39)	K3112E	probably damaging	Het
Slc6a4	G	T	11: 76,922,498 (GRCm39)	V630L	probably benign	Het
Smg1	A	T	7: 117,757,355 (GRCm39)		probably benign	Het
Tmc8	A	G	11: 117,681,900 (GRCm39)	T510A	possibly damaging	Het
Usp18	T	A	6: 121,245,627 (GRCm39)	H334Q	possibly damaging	Het
Vmn2r103	T	C	17: 20,013,229 (GRCm39)	Y117H	probably benign	Het
Vps13b	T	A	15: 35,709,625 (GRCm39)	D1857E	probably benign	Het

Other mutations in Or5p55

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01063:Or5p55	APN	7	107,566,741 (GRCm39)	missense	probably damaging	1.00
IGL01564:Or5p55	APN	7	107,567,198 (GRCm39)	missense	probably benign	0.11
IGL01615:Or5p55	APN	7	107,567,144 (GRCm39)	missense	probably damaging	1.00
IGL01777:Or5p55	APN	7	107,566,709 (GRCm39)	missense	probably damaging	1.00
IGL01999:Or5p55	APN	7	107,566,675 (GRCm39)	missense	probably benign
IGL02239:Or5p55	APN	7	107,567,254 (GRCm39)	missense	probably damaging	1.00
R0636:Or5p55	UTSW	7	107,566,679 (GRCm39)	missense	probably benign	0.00
R1986:Or5p55	UTSW	7	107,566,877 (GRCm39)	missense	probably benign
R5109:Or5p55	UTSW	7	107,567,104 (GRCm39)	missense	probably benign	0.06
R6363:Or5p55	UTSW	7	107,566,957 (GRCm39)	missense	possibly damaging	0.57
R6526:Or5p55	UTSW	7	107,566,669 (GRCm39)	missense	probably benign	0.03
R6907:Or5p55	UTSW	7	107,567,459 (GRCm39)	missense	probably damaging	1.00
R7063:Or5p55	UTSW	7	107,567,411 (GRCm39)	missense	probably benign
R7218:Or5p55	UTSW	7	107,566,874 (GRCm39)	missense	probably benign
R7240:Or5p55	UTSW	7	107,567,395 (GRCm39)	missense	probably benign	0.42
R7444:Or5p55	UTSW	7	107,566,811 (GRCm39)	missense	probably damaging	0.99
R7939:Or5p55	UTSW	7	107,566,986 (GRCm39)	nonsense	probably null
R8060:Or5p55	UTSW	7	107,566,612 (GRCm39)	missense	probably benign
R8953:Or5p55	UTSW	7	107,567,251 (GRCm39)	missense	probably benign	0.00
R9159:Or5p55	UTSW	7	107,567,524 (GRCm39)	nonsense	probably null
R9438:Or5p55	UTSW	7	107,567,000 (GRCm39)	missense	probably damaging	1.00
X0025:Or5p55	UTSW	7	107,567,395 (GRCm39)	missense	possibly damaging	0.75

Posted On

2013-11-05