Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01468:Prss39'

88186

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Prss39

Ensembl Gene

ENSMUSG00000026125

Gene Name

serine protease 39

Synonyms

Tesp1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.193) question?

Stock #

IGL01468

Quality Score

Status

Chromosome

Chromosomal Location

34537493-34542143 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

C to T at 34538481 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000140460 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000027299] [ENSMUST00000191604]

AlphaFold

O70169

Predicted Effect

probably benign
Transcript: ENSMUST00000027299

SMART Domains

Protein: ENSMUSP00000027299
Gene: ENSMUSG00000026125

Domain	Start	End	E-Value	Type
signal peptide	1	31	N/A	INTRINSIC
low complexity region	35	47	N/A	INTRINSIC
Tryp_SPc	67	307	7.97e-60	SMART
low complexity region	348	361	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000191604

SMART Domains

Protein: ENSMUSP00000140460
Gene: ENSMUSG00000026125

Domain	Start	End	E-Value	Type
signal peptide	1	31	N/A	INTRINSIC
low complexity region	35	47	N/A	INTRINSIC
Pfam:Trypsin	68	114	1.5e-12	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca7	G	A	10: 79,839,711 (GRCm39)	V781I	probably benign	Het
Aldh5a1	G	T	13: 25,095,536 (GRCm39)		probably benign	Het
Arhgap12	T	C	18: 6,057,576 (GRCm39)	T435A	probably benign	Het
Atrnl1	G	A	19: 57,688,144 (GRCm39)	V870I	probably benign	Het
Cerkl	A	T	2: 79,173,559 (GRCm39)		probably null	Het
Cntnap2	T	A	6: 47,248,305 (GRCm39)	L13*	probably null	Het
Cr2	G	A	1: 194,850,843 (GRCm39)	P208S	probably damaging	Het
Dapk1	A	G	13: 60,908,612 (GRCm39)	D1075G	probably benign	Het
Dhx57	T	A	17: 80,563,039 (GRCm39)	K863*	probably null	Het
Dnaaf5	C	A	5: 139,137,235 (GRCm39)		probably null	Het
Fbxw7	T	A	3: 84,879,806 (GRCm39)	I336K	probably benign	Het
Ftcd	A	G	10: 76,420,421 (GRCm39)	D385G	probably benign	Het
Gm10153	T	C	7: 141,743,778 (GRCm39)	S117G	unknown	Het
Gzmb	T	C	14: 56,497,772 (GRCm39)	Y156C	probably benign	Het
Herc3	T	A	6: 58,831,880 (GRCm39)	D83E	probably benign	Het
Kif2b	A	G	11: 91,467,191 (GRCm39)	V364A	probably damaging	Het
Mknk2	A	G	10: 80,503,498 (GRCm39)		probably benign	Het
Or7a36	A	T	10: 78,819,696 (GRCm39)	Q24L	probably damaging	Het
Pgm1	A	T	4: 99,819,367 (GRCm39)	N197I	possibly damaging	Het
Shroom3	T	C	5: 93,088,201 (GRCm39)	V236A	probably damaging	Het
Slc17a8	C	T	10: 89,427,883 (GRCm39)		probably null	Het
Slc24a3	A	G	2: 145,455,500 (GRCm39)	Y463C	probably benign	Het
Slc4a7	A	G	14: 14,737,480 (GRCm38)	E149G	probably damaging	Het
Synj1	G	A	16: 90,807,060 (GRCm39)		probably benign	Het
Tas2r138	T	A	6: 40,589,410 (GRCm39)	M279L	probably benign	Het
Terb1	A	G	8: 105,208,799 (GRCm39)		probably benign	Het
Tiparp	G	T	3: 65,460,030 (GRCm39)	G442*	probably null	Het
Trmt5	C	T	12: 73,327,878 (GRCm39)	V442I	probably benign	Het
Tsc2	T	C	17: 24,840,071 (GRCm39)	I383V	possibly damaging	Het
Uchl4	A	G	9: 64,142,998 (GRCm39)	T160A	possibly damaging	Het
Vmn2r3	A	T	3: 64,182,382 (GRCm39)	M439K	possibly damaging	Het
Vmn2r4	A	T	3: 64,313,816 (GRCm39)	N388K	probably damaging	Het
Vmn2r52	A	T	7: 9,892,868 (GRCm39)	L757Q	probably damaging	Het
Zfp518a	T	C	19: 40,904,475 (GRCm39)	V1468A	probably benign	Het
Zxdc	A	T	6: 90,350,761 (GRCm39)	E404V	probably damaging	Het

Other mutations in Prss39

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01432:Prss39	APN	1	34,541,216 (GRCm39)	missense	probably benign	0.01
IGL01744:Prss39	APN	1	34,541,280 (GRCm39)	splice site	probably null
IGL02224:Prss39	APN	1	34,538,459 (GRCm39)	missense	probably damaging	1.00
R0128:Prss39	UTSW	1	34,541,281 (GRCm39)	unclassified	probably benign
R0130:Prss39	UTSW	1	34,541,281 (GRCm39)	unclassified	probably benign
R0269:Prss39	UTSW	1	34,539,279 (GRCm39)	missense	probably damaging	0.96
R0617:Prss39	UTSW	1	34,539,279 (GRCm39)	missense	probably damaging	0.96
R1078:Prss39	UTSW	1	34,541,167 (GRCm39)	missense	probably benign	0.00
R1539:Prss39	UTSW	1	34,537,616 (GRCm39)	missense	possibly damaging	0.85
R1796:Prss39	UTSW	1	34,539,114 (GRCm39)	missense	possibly damaging	0.70
R4644:Prss39	UTSW	1	34,541,207 (GRCm39)	missense	probably damaging	0.96
R5417:Prss39	UTSW	1	34,539,209 (GRCm39)	missense	probably benign
R5496:Prss39	UTSW	1	34,539,342 (GRCm39)	missense	possibly damaging	0.92
R5511:Prss39	UTSW	1	34,541,878 (GRCm39)	missense	possibly damaging	0.65
R5977:Prss39	UTSW	1	34,541,783 (GRCm39)	missense	probably damaging	1.00
R6333:Prss39	UTSW	1	34,539,150 (GRCm39)	missense	probably benign	0.02
R6833:Prss39	UTSW	1	34,537,697 (GRCm39)	missense	possibly damaging	0.84
R6834:Prss39	UTSW	1	34,537,697 (GRCm39)	missense	possibly damaging	0.84
R7230:Prss39	UTSW	1	34,541,228 (GRCm39)	missense	probably damaging	0.98
R7261:Prss39	UTSW	1	34,539,369 (GRCm39)	missense	probably damaging	0.99
R7467:Prss39	UTSW	1	34,538,473 (GRCm39)	critical splice donor site	probably null
R7509:Prss39	UTSW	1	34,539,280 (GRCm39)	missense	possibly damaging	0.85
R7709:Prss39	UTSW	1	34,541,709 (GRCm39)	missense	probably damaging	1.00
R7894:Prss39	UTSW	1	34,539,308 (GRCm39)	missense	probably benign	0.16
R8730:Prss39	UTSW	1	34,539,198 (GRCm39)	missense	probably damaging	1.00
R9405:Prss39	UTSW	1	34,538,344 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-11-18