Incidental Mutation 'IGL01569:Vmn1r8'
| ID |
91089 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn1r8
|
| Ensembl Gene |
ENSMUSG00000061208 |
| Gene Name |
vomeronasal 1 receptor 8 |
| Synonyms |
V1rc32 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.059)
|
| Stock # |
IGL01569
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
6 |
| Chromosomal Location |
57012898-57014110 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 57013272 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Tyrosine
at position 108
(N108Y)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000154298
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000078186]
[ENSMUST00000227706]
[ENSMUST00000228690]
|
| AlphaFold |
Q8R2C2 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000078186
AA Change: N108Y
PolyPhen 2
Score 0.702 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000093561
Gene: ENSMUSG00000061208
AA Change: N108Y
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
28 |
293 |
1.2e-58 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000227706
AA Change: N108Y
PolyPhen 2
Score 0.702 (Sensitivity: 0.86; Specificity: 0.92)
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000228690
AA Change: N108Y
PolyPhen 2
Score 0.702 (Sensitivity: 0.86; Specificity: 0.92)
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 25 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700010I14Rik |
T |
C |
17: 9,215,827 (GRCm39) |
V311A |
probably benign |
Het |
| Bdh1 |
T |
C |
16: 31,273,909 (GRCm39) |
M194T |
probably benign |
Het |
| Dnmbp |
T |
C |
19: 43,863,295 (GRCm39) |
R808G |
probably benign |
Het |
| Esco2 |
T |
C |
14: 66,063,977 (GRCm39) |
I402M |
probably benign |
Het |
| Gm5422 |
T |
C |
10: 31,125,897 (GRCm39) |
|
noncoding transcript |
Het |
| Il5ra |
C |
A |
6: 106,708,794 (GRCm39) |
M1I |
probably null |
Het |
| Kcnk4 |
T |
A |
19: 6,904,545 (GRCm39) |
I240F |
probably damaging |
Het |
| Mast4 |
T |
C |
13: 102,897,523 (GRCm39) |
E698G |
probably damaging |
Het |
| Mkln1 |
A |
G |
6: 31,405,063 (GRCm39) |
|
probably benign |
Het |
| Mypn |
C |
T |
10: 62,963,538 (GRCm39) |
G978R |
probably damaging |
Het |
| Or2m12 |
T |
C |
16: 19,105,410 (GRCm39) |
T28A |
probably benign |
Het |
| Podn |
T |
A |
4: 107,881,496 (GRCm39) |
Y6F |
probably damaging |
Het |
| Psmg2 |
G |
A |
18: 67,786,293 (GRCm39) |
V218I |
probably benign |
Het |
| Rad54l |
T |
C |
4: 115,956,195 (GRCm39) |
D544G |
probably damaging |
Het |
| Reck |
C |
A |
4: 43,925,172 (GRCm39) |
S470R |
probably benign |
Het |
| Sik3 |
A |
G |
9: 46,123,024 (GRCm39) |
H891R |
probably benign |
Het |
| Tbata |
C |
T |
10: 61,011,739 (GRCm39) |
R92* |
probably null |
Het |
| Tdrd1 |
A |
G |
19: 56,822,841 (GRCm39) |
N103S |
probably damaging |
Het |
| Timm21 |
A |
G |
18: 84,969,400 (GRCm39) |
V8A |
probably benign |
Het |
| Tnn |
A |
G |
1: 159,948,124 (GRCm39) |
V863A |
possibly damaging |
Het |
| Togaram1 |
A |
G |
12: 65,029,436 (GRCm39) |
D953G |
possibly damaging |
Het |
| Tpm1 |
T |
C |
9: 66,938,390 (GRCm39) |
|
probably null |
Het |
| Trgv4 |
A |
G |
13: 19,369,678 (GRCm39) |
|
probably benign |
Het |
| Vmn1r89 |
T |
C |
7: 12,953,432 (GRCm39) |
M56T |
probably benign |
Het |
| Ythdc2 |
A |
G |
18: 45,020,718 (GRCm39) |
E1434G |
probably benign |
Het |
|
| Other mutations in Vmn1r8 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01820:Vmn1r8
|
APN |
6 |
57,013,653 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02416:Vmn1r8
|
APN |
6 |
57,013,605 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02496:Vmn1r8
|
APN |
6 |
57,013,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02930:Vmn1r8
|
APN |
6 |
57,013,579 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02954:Vmn1r8
|
APN |
6 |
57,013,315 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL03235:Vmn1r8
|
APN |
6 |
57,013,746 (GRCm39) |
nonsense |
probably null |
|
|
IGL03353:Vmn1r8
|
APN |
6 |
57,013,776 (GRCm39) |
missense |
probably benign |
0.03 |
|
PIT4494001:Vmn1r8
|
UTSW |
6 |
57,013,712 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0656:Vmn1r8
|
UTSW |
6 |
57,013,573 (GRCm39) |
missense |
probably benign |
0.35 |
|
R1328:Vmn1r8
|
UTSW |
6 |
57,013,278 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1846:Vmn1r8
|
UTSW |
6 |
57,013,413 (GRCm39) |
missense |
probably benign |
0.06 |
|
R2083:Vmn1r8
|
UTSW |
6 |
57,013,325 (GRCm39) |
missense |
probably benign |
0.21 |
|
R3683:Vmn1r8
|
UTSW |
6 |
57,013,260 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4134:Vmn1r8
|
UTSW |
6 |
57,013,705 (GRCm39) |
missense |
probably benign |
|
|
R4754:Vmn1r8
|
UTSW |
6 |
57,012,952 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
R4857:Vmn1r8
|
UTSW |
6 |
57,013,338 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5787:Vmn1r8
|
UTSW |
6 |
57,013,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6158:Vmn1r8
|
UTSW |
6 |
57,013,274 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6711:Vmn1r8
|
UTSW |
6 |
57,013,444 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6971:Vmn1r8
|
UTSW |
6 |
57,013,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8066:Vmn1r8
|
UTSW |
6 |
57,013,419 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8261:Vmn1r8
|
UTSW |
6 |
57,013,158 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8526:Vmn1r8
|
UTSW |
6 |
57,013,362 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8552:Vmn1r8
|
UTSW |
6 |
57,013,138 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R8692:Vmn1r8
|
UTSW |
6 |
57,013,557 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8712:Vmn1r8
|
UTSW |
6 |
57,013,665 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9306:Vmn1r8
|
UTSW |
6 |
57,013,713 (GRCm39) |
missense |
probably benign |
0.12 |
|
| Posted On |
2013-12-09 |
Incidental Mutation