Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01618:Zfyve21'

92477

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfyve21

Ensembl Gene

ENSMUSG00000021286

Gene Name

zinc finger, FYVE domain containing 21

Synonyms

1110013H04Rik, C85416

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01618

Quality Score

Status

Chromosome

Chromosomal Location

111780600-111794822 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

C to T at 111794247 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s): [ENSMUST00000021714] [ENSMUST00000054815] [ENSMUST00000220486] [ENSMUST00000220616] [ENSMUST00000221375] [ENSMUST00000222843]

AlphaFold

Q8VCM3

Predicted Effect

probably benign
Transcript: ENSMUST00000021714

SMART Domains

Protein: ENSMUSP00000021714
Gene: ENSMUSG00000021286

Domain	Start	End	E-Value	Type
FYVE	36	105	7.11e-16	SMART
Pfam:ZFYVE21_C	108	233	1.1e-56	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000054815

SMART Domains

Protein: ENSMUSP00000062464
Gene: ENSMUSG00000021285

Domain	Start	End	E-Value	Type
PDB:2UWQ\|A	1	83	8e-35	PDB
Blast:RA	5	84	3e-47	BLAST
coiled coil region	123	305	N/A	INTRINSIC
low complexity region	437	476	N/A	INTRINSIC
low complexity region	523	539	N/A	INTRINSIC
low complexity region	610	625	N/A	INTRINSIC
PDB:4IRV\|H	695	741	1e-12	PDB
ANK	917	946	4.16e-7	SMART
ANK	950	979	4.63e-5	SMART
SH3	1019	1077	1.79e-18	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000220486

Predicted Effect

probably benign
Transcript: ENSMUST00000220616

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000221313

Predicted Effect

probably benign
Transcript: ENSMUST00000221375

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000221488

Predicted Effect

probably benign
Transcript: ENSMUST00000222843

Predicted Effect

probably benign
Transcript: ENSMUST00000223211

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acsl5	C	T	19: 55,261,265 (GRCm39)	A74V	probably benign	Het
Adh4	C	T	3: 138,134,788 (GRCm39)		probably benign	Het
Aldh1a3	G	A	7: 66,058,978 (GRCm39)	T239I	probably damaging	Het
Anxa9	A	G	3: 95,207,847 (GRCm39)		probably null	Het
Atp5me	C	A	5: 108,581,899 (GRCm39)	K28N	probably damaging	Het
C9	T	G	15: 6,489,149 (GRCm39)	Y169D	probably benign	Het
Chat	T	A	14: 32,168,849 (GRCm39)		probably null	Het
Csmd3	C	T	15: 47,874,479 (GRCm39)	E706K	probably benign	Het
Ctbs	A	G	3: 146,160,867 (GRCm39)	K145E	probably benign	Het
Dennd5a	A	G	7: 109,533,302 (GRCm39)	M156T	probably damaging	Het
Dhx29	A	G	13: 113,101,756 (GRCm39)	Y1275C	probably damaging	Het
Dpp10	A	T	1: 123,295,596 (GRCm39)	F517Y	probably benign	Het
Dst	G	A	1: 34,227,990 (GRCm39)	W1536*	probably null	Het
Galc	T	C	12: 98,218,340 (GRCm39)	T171A	possibly damaging	Het
Gsap	T	C	5: 21,431,246 (GRCm39)	I190T	probably damaging	Het
Hars2	A	T	18: 36,922,630 (GRCm39)	R388*	probably null	Het
Igsf21	C	T	4: 139,834,675 (GRCm39)	G66S	possibly damaging	Het
Itgbl1	T	A	14: 124,065,211 (GRCm39)	S122T	possibly damaging	Het
Jhy	G	T	9: 40,872,260 (GRCm39)	T83K	possibly damaging	Het
Kcne4	A	T	1: 78,795,525 (GRCm39)	M58L	possibly damaging	Het
Lamc3	T	A	2: 31,802,119 (GRCm39)	I509N	probably damaging	Het
Lpar6	T	C	14: 73,476,506 (GRCm39)	S156P	probably damaging	Het
Man2c1	T	C	9: 57,048,840 (GRCm39)		probably benign	Het
Marchf11	T	C	15: 26,409,285 (GRCm39)	I328T	possibly damaging	Het
Mc3r	T	A	2: 172,091,290 (GRCm39)	C171S	probably benign	Het
Muc4	A	T	16: 32,577,001 (GRCm39)	Q2167L	unknown	Het
Myom1	T	C	17: 71,406,988 (GRCm39)	V1135A	possibly damaging	Het
Nectin1	C	T	9: 43,702,555 (GRCm39)	R101*	probably null	Het
Nxpe4	T	C	9: 48,305,440 (GRCm39)	S277P	possibly damaging	Het
Or1e35	T	C	11: 73,798,303 (GRCm39)	N5S	probably damaging	Het
Or2a52	T	A	6: 43,144,637 (GRCm39)	V215E	probably damaging	Het
Or52r1c	G	A	7: 102,735,582 (GRCm39)	V281I	probably benign	Het
Or5b106	T	A	19: 13,123,614 (GRCm39)	K136N	probably benign	Het
Or5w19	A	C	2: 87,698,488 (GRCm39)	D51A	probably damaging	Het
Pappa2	G	T	1: 158,684,948 (GRCm39)	N730K	probably damaging	Het
Prepl	A	G	17: 85,373,709 (GRCm39)	V586A	probably damaging	Het
Prrc2a	T	C	17: 35,368,529 (GRCm39)	Y2098C	probably damaging	Het
Rdh16	G	A	10: 127,637,176 (GRCm39)	C37Y	probably damaging	Het
Rnd1	A	T	15: 98,571,746 (GRCm39)	M100K	probably benign	Het
Sema3c	A	G	5: 17,877,504 (GRCm39)	N204D	probably damaging	Het
Susd4	A	G	1: 182,686,026 (GRCm39)		probably null	Het
Taar7f	G	T	10: 23,926,239 (GRCm39)	A278S	possibly damaging	Het
Tle4	T	A	19: 14,522,178 (GRCm39)	M122L	probably benign	Het
Trim9	C	T	12: 70,295,125 (GRCm39)	V662I	probably benign	Het
Vmn2r10	C	A	5: 109,150,345 (GRCm39)	C233F	probably damaging	Het
Vmn2r98	A	C	17: 19,285,521 (GRCm39)	T114P	possibly damaging	Het
Zng1	T	C	19: 24,918,140 (GRCm39)	E210G	possibly damaging	Het

Other mutations in Zfyve21

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00969:Zfyve21	APN	12	111,791,368 (GRCm39)	splice site	probably benign
IGL02729:Zfyve21	APN	12	111,791,485 (GRCm39)	missense	probably benign	0.01
R0513:Zfyve21	UTSW	12	111,789,698 (GRCm39)	missense	possibly damaging	0.65
R1813:Zfyve21	UTSW	12	111,791,328 (GRCm39)	missense	probably damaging	0.99
R6351:Zfyve21	UTSW	12	111,794,028 (GRCm39)	missense	probably benign	0.01
R7355:Zfyve21	UTSW	12	111,791,485 (GRCm39)	missense	possibly damaging	0.94
R7514:Zfyve21	UTSW	12	111,790,249 (GRCm39)	missense	probably damaging	1.00
R8314:Zfyve21	UTSW	12	111,789,715 (GRCm39)	missense	probably benign	0.07
T0975:Zfyve21	UTSW	12	111,794,067 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-12-09