Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01595:Mapk15'

93376

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mapk15

Ensembl Gene

ENSMUSG00000063704

Gene Name

mitogen-activated protein kinase 15

Synonyms

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01595

Quality Score

Status

Chromosome

Chromosomal Location

75865618-75871003 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 75867129 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Proline to Glutamine at position 82 (P82Q)

Ref Sequence

ENSEMBL: ENSMUSP00000087098 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000089669]

AlphaFold

Q80Y86

Predicted Effect

probably benign
Transcript: ENSMUST00000089669
AA Change: P82Q

PolyPhen 2 Score 0.040 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000087098
Gene: ENSMUSG00000063704
AA Change: P82Q

Domain	Start	End	E-Value	Type
S_TKc	14	305	7.08e-97	SMART
low complexity region	391	404	N/A	INTRINSIC
low complexity region	424	434	N/A	INTRINSIC
low complexity region	475	505	N/A	INTRINSIC
low complexity region	513	525	N/A	INTRINSIC
low complexity region	538	548	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000160092

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000160637

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000161961

Predicted Effect

probably benign
Transcript: ENSMUST00000230929

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acbd5	A	G	2: 22,968,181 (GRCm39)	M111V	probably damaging	Het
Adamts14	A	T	10: 61,041,252 (GRCm39)	H819Q	probably damaging	Het
Adamts7	T	A	9: 90,075,359 (GRCm39)	N1072K	probably benign	Het
Ahnak	T	A	19: 8,980,865 (GRCm39)	Y716*	probably null	Het
Arfgef3	T	C	10: 18,470,660 (GRCm39)	K1702E	possibly damaging	Het
BB014433	C	A	8: 15,092,499 (GRCm39)		probably null	Het
Bdnf	A	T	2: 109,554,273 (GRCm39)	K176*	probably null	Het
C2cd5	C	T	6: 142,963,748 (GRCm39)	R879H	probably damaging	Het
Capn11	T	A	17: 45,950,360 (GRCm39)	H327L	probably benign	Het
Ccdc68	A	G	18: 70,089,117 (GRCm39)	N220S	probably benign	Het
Cftr	T	C	6: 18,198,238 (GRCm39)		probably benign	Het
Clca3a2	G	A	3: 144,793,768 (GRCm39)	L296F	probably damaging	Het
Cubn	A	T	2: 13,330,027 (GRCm39)	L2618Q	probably benign	Het
Gfi1b	A	G	2: 28,501,429 (GRCm39)		probably null	Het
Gpr37	G	T	6: 25,669,572 (GRCm39)	T424N	probably damaging	Het
Kank3	G	A	17: 34,038,154 (GRCm39)		probably null	Het
Kcnh5	T	C	12: 74,945,101 (GRCm39)	Q716R	probably benign	Het
Kntc1	G	A	5: 123,941,758 (GRCm39)	M1817I	probably benign	Het
Krt79	T	G	15: 101,840,206 (GRCm39)	E330A	probably damaging	Het
Myh15	A	T	16: 48,993,312 (GRCm39)	D1649V	probably damaging	Het
Myo1d	T	C	11: 80,566,936 (GRCm39)	I326V	probably benign	Het
Nek9	A	T	12: 85,361,194 (GRCm39)	W504R	probably damaging	Het
Nlrp4c	T	A	7: 6,069,111 (GRCm39)	C337*	probably null	Het
Nup160	A	G	2: 90,560,081 (GRCm39)	N1269D	probably damaging	Het
Or52e3	A	G	7: 102,869,558 (GRCm39)	D211G	probably damaging	Het
Or56b2	T	C	7: 104,337,285 (GRCm39)	M21T	possibly damaging	Het
Or8c10	T	C	9: 38,279,346 (GRCm39)	V168A	probably benign	Het
Pde6a	A	G	18: 61,414,599 (GRCm39)	M36V	probably damaging	Het
Perp	A	G	10: 18,731,407 (GRCm39)	Q122R	probably damaging	Het
S100a7a	T	C	3: 90,565,107 (GRCm39)	Y101H	probably benign	Het
Sbk2	C	A	7: 4,960,712 (GRCm39)	V153L	possibly damaging	Het
Serpinb7	A	T	1: 107,356,052 (GRCm39)	N25I	probably damaging	Het
Tbx5	A	T	5: 119,978,903 (GRCm39)	D105V	probably damaging	Het
Trip6	T	A	5: 137,311,675 (GRCm39)	T101S	probably benign	Het
Ush2a	T	A	1: 188,386,921 (GRCm39)		probably null	Het

Other mutations in Mapk15

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02075:Mapk15	APN	15	75,866,737 (GRCm39)	missense	probably benign	0.35
IGL02395:Mapk15	APN	15	75,870,019 (GRCm39)	missense	probably benign
IGL03052:Mapk15	UTSW	15	75,865,731 (GRCm39)	missense	probably benign	0.01
R0008:Mapk15	UTSW	15	75,870,103 (GRCm39)	missense	probably benign	0.08
R0109:Mapk15	UTSW	15	75,867,926 (GRCm39)	nonsense	probably null
R0109:Mapk15	UTSW	15	75,867,926 (GRCm39)	nonsense	probably null
R1148:Mapk15	UTSW	15	75,870,004 (GRCm39)	missense	probably benign
R1148:Mapk15	UTSW	15	75,870,004 (GRCm39)	missense	probably benign
R2406:Mapk15	UTSW	15	75,870,697 (GRCm39)	missense	possibly damaging	0.75
R4526:Mapk15	UTSW	15	75,867,104 (GRCm39)	missense	possibly damaging	0.83
R4572:Mapk15	UTSW	15	75,870,599 (GRCm39)	splice site	probably benign
R4613:Mapk15	UTSW	15	75,867,759 (GRCm39)	missense	probably damaging	0.98
R5861:Mapk15	UTSW	15	75,868,208 (GRCm39)	unclassified	probably benign
R6912:Mapk15	UTSW	15	75,865,747 (GRCm39)	missense	probably damaging	0.99
R7554:Mapk15	UTSW	15	75,867,745 (GRCm39)	missense	possibly damaging	0.63
R7620:Mapk15	UTSW	15	75,870,697 (GRCm39)	missense	probably benign	0.00
R7923:Mapk15	UTSW	15	75,868,295 (GRCm39)	missense	probably damaging	1.00
R9308:Mapk15	UTSW	15	75,865,714 (GRCm39)	nonsense	probably null
R9744:Mapk15	UTSW	15	75,869,912 (GRCm39)	missense	possibly damaging	0.78
Z1177:Mapk15	UTSW	15	75,870,310 (GRCm39)	nonsense	probably null

Posted On

2013-12-09