Incidental Mutation 'R0026:Yipf1'
ID 15103
Institutional Source Beutler Lab
Gene Symbol Yipf1
Ensembl Gene ENSMUSG00000057375
Gene Name Yip1 domain family, member 1
Synonyms C030002N13Rik
MMRRC Submission 038321-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0026 (G1)
Quality Score
Status Validated
Chromosome 4
Chromosomal Location 107171560-107217020 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 107202357 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Stop codon at position 240 (L240*)
Ref Sequence ENSEMBL: ENSMUSP00000115626 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075693] [ENSMUST00000128284] [ENSMUST00000139527]
AlphaFold Q91VU1
Predicted Effect probably null
Transcript: ENSMUST00000075693
AA Change: L267*
SMART Domains Protein: ENSMUSP00000075113
Gene: ENSMUSG00000057375
AA Change: L267*

DomainStartEndE-ValueType
Pfam:Yip1 86 274 6.6e-25 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000124254
Predicted Effect probably benign
Transcript: ENSMUST00000128284
SMART Domains Protein: ENSMUSP00000114898
Gene: ENSMUSG00000057375

DomainStartEndE-ValueType
Pfam:Yip1 86 244 8.1e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137391
Predicted Effect probably null
Transcript: ENSMUST00000139527
AA Change: L240*
SMART Domains Protein: ENSMUSP00000115626
Gene: ENSMUSG00000057375
AA Change: L240*

DomainStartEndE-ValueType
Pfam:Yip1 62 247 3.6e-24 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143106
Predicted Effect noncoding transcript
Transcript: ENSMUST00000146829
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156265
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 78.7%
  • 3x: 68.7%
  • 10x: 42.4%
  • 20x: 22.6%
Validation Efficiency 96% (75/78)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit no detectable phenotypic abnormalities. [provided by MGI curators]
Allele List at MGI

All alleles(8) : Targeted(2) Gene trapped(6)
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca16 C T 7: 120,077,146 (GRCm39) probably benign Het
Acot10 G A 15: 20,666,322 (GRCm39) L140F probably benign Het
Asph A C 4: 9,601,361 (GRCm39) S129A probably damaging Het
Atrn T C 2: 130,799,840 (GRCm39) Y406H probably damaging Het
B4galt3 C T 1: 171,101,831 (GRCm39) probably benign Het
BC016579 T C 16: 45,460,730 (GRCm39) T113A probably benign Het
Bmpr1b A G 3: 141,576,494 (GRCm39) L113P probably benign Het
Casq1 T C 1: 172,046,967 (GRCm39) probably benign Het
Ccdc187 T C 2: 26,171,365 (GRCm39) D371G probably benign Het
Clstn1 G A 4: 149,719,253 (GRCm39) V361M probably damaging Het
Cyp4b1 C T 4: 115,504,718 (GRCm39) G56D possibly damaging Het
Dock5 C A 14: 68,083,530 (GRCm39) E126D probably benign Het
Exph5 A T 9: 53,287,779 (GRCm39) D1620V probably benign Het
Fancd2os G T 6: 113,574,652 (GRCm39) T118N probably damaging Het
Fli1 A G 9: 32,387,880 (GRCm39) Y37H probably damaging Het
Gm17521 G A X: 121,939,239 (GRCm39) S43L probably benign Het
Gnb3 A G 6: 124,814,380 (GRCm39) V135A probably benign Het
Ibtk A G 9: 85,572,356 (GRCm39) V1278A probably benign Het
Ighv1-58 G A 12: 115,275,907 (GRCm39) T77I probably benign Het
Lgsn T A 1: 31,242,524 (GRCm39) V202D probably damaging Het
Madd A G 2: 91,006,053 (GRCm39) F381L possibly damaging Het
Ntf3 T A 6: 126,078,768 (GRCm39) N246I probably damaging Het
Pds5b G A 5: 150,673,295 (GRCm39) probably benign Het
Ppp3cb C T 14: 20,581,836 (GRCm39) V60I probably benign Het
Prc1 T C 7: 79,960,809 (GRCm39) probably benign Het
Prpf31 T A 7: 3,642,667 (GRCm39) N413K probably benign Het
Rapgef5 T C 12: 117,652,896 (GRCm39) S307P probably benign Het
Rbfox2 T C 15: 76,968,357 (GRCm39) T435A possibly damaging Het
Senp1 T C 15: 97,974,549 (GRCm39) R88G probably damaging Het
Slc35b1 T C 11: 95,281,468 (GRCm39) S294P probably benign Het
Slc44a5 G A 3: 153,945,907 (GRCm39) probably benign Het
Spata31e2 T A 1: 26,722,450 (GRCm39) D910V probably benign Het
Taf1d T A 9: 15,219,944 (GRCm39) S64R probably damaging Het
Trim6 T A 7: 103,875,016 (GRCm39) probably null Het
Ttn T C 2: 76,599,534 (GRCm39) T19186A probably damaging Het
Uchl4 A T 9: 64,142,653 (GRCm39) probably null Het
Usp32 T C 11: 84,922,900 (GRCm39) S673G possibly damaging Het
Utrn T C 10: 12,601,940 (GRCm39) probably benign Het
Vps13b T C 15: 35,923,447 (GRCm39) I3774T possibly damaging Het
Vwa3a A G 7: 120,379,434 (GRCm39) Q513R probably damaging Het
Other mutations in Yipf1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02957:Yipf1 APN 4 107,193,347 (GRCm39) missense probably damaging 0.99
R0026:Yipf1 UTSW 4 107,202,357 (GRCm39) nonsense probably null
R0521:Yipf1 UTSW 4 107,193,387 (GRCm39) missense probably benign 0.02
R4609:Yipf1 UTSW 4 107,201,880 (GRCm39) splice site probably null
R4781:Yipf1 UTSW 4 107,193,355 (GRCm39) missense probably benign 0.11
R4790:Yipf1 UTSW 4 107,193,396 (GRCm39) splice site probably null
R4881:Yipf1 UTSW 4 107,202,288 (GRCm39) missense possibly damaging 0.93
R5655:Yipf1 UTSW 4 107,202,354 (GRCm39) missense probably damaging 0.99
R7365:Yipf1 UTSW 4 107,207,738 (GRCm39) splice site probably null
R7633:Yipf1 UTSW 4 107,176,193 (GRCm39) missense probably benign
R8805:Yipf1 UTSW 4 107,193,355 (GRCm39) missense probably benign 0.11
R9756:Yipf1 UTSW 4 107,176,247 (GRCm39) missense probably benign
Z1176:Yipf1 UTSW 4 107,202,335 (GRCm39) missense probably damaging 1.00
Posted On 2012-12-12